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Arid3b Gene Detail
Summary
  • Symbol
    Arid3b
  • Name
    AT rich interactive domain 3B (BRIGHT-like)
  • Synonyms
    Bdp, Dri2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930768
    NCBI Gene: 56380
  • Gene Overview
    MyGene.info: ARID3B
Location & Maps
more
  • Sequence Map
    Chr9:57790353-57836793 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46441 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ARID3B, AT-rich interaction domain 3B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ARID3B, AT-rich interaction domain 3B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BDP, DRIL2
  • Links
    NCBI Gene ID: 10620
    neXtProt AC: NX_Q8IVW6

  • Chr Location
    15q24; chr15:74541177-74598131 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    92
  • Gene trapped
    89
  • Targeted
    3
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele die before E11.5 displaying variable phenotypes associated with impaired generation of cranial-mesenchymal cells in the first and second branchial arches. Common defects include a wavy neural tube, small branchial arches, and a defective cardiovascular system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036791 VEGA Gene Model | MGI Sequence Detail 46441 C57BL/6J ±  kb
transcript OTTMUST00000094427 VEGA | MGI Sequence Detail 4171 Not Applicable  
polypeptide OTTMUSP00000052509 VEGA | MGI Sequence Detail 568 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    171 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000004266 AT-rich interactive domain-containing protein 3B
  • InterPro Domains
    IPR001606 ARID DNA-binding domain
    IPR023334 REKLES domain
Molecular
Reagents
less
  • All nucleic 66
    cDNA 65
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 12
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:51742 Herrscher RF, et al., The immunoglobulin heavy-chain matrix-associating regions are bound by Bright: a B cell-specific trans-activator that describes a new DNA-binding protein family. Genes Dev. 1995 Dec 15;9(24):3067-82
  • Latest
    J:222450 Uribe V, et al., Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory