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Ube2d2a Gene Detail
Summary
  • Symbol
    Ube2d2a
  • Name
    ubiquitin-conjugating enzyme E2D 2A
  • Synonyms
    1500034D03Rik, ubc4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930715
    NCBI Gene: 56550
  • Gene Overview
    MyGene.info: UBE2D2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:35771559-35807172 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 19.24 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    179 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930715
protein coding gene Chr18:35771559-35807172 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024271
protein coding gene Chr18:34106985-34144309 (+)
A/J MGP_AJ_G0024237
protein coding gene Chr18:32928751-32966557 (+)
AKR/J MGP_AKRJ_G0024205
protein coding gene Chr18:33861840-33897425 (+)
BALB/cJ MGP_BALBcJ_G0024237
protein coding gene Chr18:32973094-33016617 (+)
C3H/HeJ MGP_C3HHeJ_G0024004
protein coding gene Chr18:33893388-33928970 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024678
protein coding gene Chr18:35326532-35364197 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022118
protein coding gene Chr18:33028400-33063002 (+)
CAST/EiJ MGP_CASTEiJ_G0023479
protein coding gene Chr18:33871310-33927232 (+)
CBA/J MGP_CBAJ_G0023972
protein coding gene Chr18:36355293-36400040 (+)
DBA/2J MGP_DBA2J_G0024104
protein coding gene Chr18:32560138-32595868 (+)
FVB/NJ MGP_FVBNJ_G0024071
protein coding gene Chr18:32253379-32288938 (+)
LP/J MGP_LPJ_G0024186
protein coding gene Chr18:34155827-34191876 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024099
protein coding gene Chr18:37570791-37606492 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024727
protein coding gene Chr18:33693866-33730498 (+)
PWK/PhJ MGP_PWKPhJ_G0023223
protein coding gene Chr18:32791674-32827833 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023030
protein coding gene Chr18:33951883-33996101 (+)
WSB/EiJ MGP_WSBEiJ_G0023542
protein coding gene Chr18:33625660-33662597 (+)



Homology
more
  • Human Ortholog
    UBE2D2, ubiquitin conjugating enzyme E2 D2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    UBE2D2, ubiquitin conjugating enzyme E2 D2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E2(17)KB2, PUBC1, UBC4, UBC4/5, UBCH4, UBCH5B
  • Links
    NCBI Gene ID: 7322
    neXtProt AC: NX_P62837
    UniProt: P62837

  • Chr Location
    5q31.2; chr5:139561166-139628434 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display a delay in testis maturation but have normal spermatogenesis, sperm motility, and fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56550 NCBI Gene Model | MGI Sequence Detail 35614 C57BL/6J ±  kb
transcript NM_019912 RefSeq | MGI Sequence Detail 2483 C57BL/6  
polypeptide P62838 UniProt | EBI | MGI Sequence Detail 147 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 243
    cDNA 243

    Microarray probesets 8
Other
Accession IDs
less
MGI:1919677
References
more
  • Summaries
    All 40
    Gene Ontology 11
    Phenotypes 5
  • Earliest
    J:41090 Hatakeyama S, et al., Subcellular localization and ubiquitin-conjugating enzyme (E2) interactions of mammalian HECT family ubiquitin protein ligases. J Biol Chem. 1997 Jun 13;272(24):15085-92
  • Latest
    J:248448 McKelvey AC, et al., RING finger E3 ligase PPP1R11 regulates TLR2 signaling and innate immunity. Elife. 2016 Nov 2;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory