About   Help   FAQ
Stx1b
Gene Detail
Symbol

Name
ID
Stx1b
syntaxin 1B
MGI:1930705
Synonyms
Stx1b2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:127803900-127824549 bp, - strand
From VEGA annotation of GRCm38

  20650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STX1B
Protein SuperFamily: syntaxin
Gene Tree: Stx1b

Human
homologs
STX1B, syntaxin 1B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 112755
neXtProt AC: NX_P61266

Human Synonyms: GEFSP9, STX1B1, STX1B2

Human Chr (Location): 16p11.2; chr16:30989256-31010638 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human STX1B

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(4) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.
 
Interactions
Stx1b interacts with 334 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process exocytosis, intracellular protein transport, ...
Component cell, endomembrane system, ...
Function protein binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (7)    Tissues (4)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 3
cDNA source data(2)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase stx1b ; ZFIN stx1b    NEW 
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031121 (Evidence)
Ensembl Gene Model ENSMUSG00000030806 (Evidence)
Entrez Gene 56216 (Evidence)
DFCI TC1595842
DoTS DT.40167259
NIA Mouse Gene Index U029309
Consensus CDS Project CCDS40146.1
International Mouse Phenotyping Consortium Status Stx1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031121 VEGA Gene Model | MGI Sequence Detail 20650 C57BL/6J ±  kb
transcript OTTMUST00000077102 VEGA | MGI Sequence Detail 4536 Not Applicable 
polypeptide OTTMUSP00000040686 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015793 syntaxin-1B
References
(Earliest) J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
(Latest) J:217856 Corradini I, et al., Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs. Cereb Cortex. 2014 Feb;24(2):364-76
All references(51)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory