Stx1b
Gene Detail

Symbol Name ID

Stx1b syntaxin 1B MGI:1930705

Synonyms

Stx1b2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:127803900-127824549 bp, - strand From VEGA annotation of GRCm38   20650 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx1b

Human homologs

Human Homolog		STX1B, syntaxin 1B
NCBI Gene ID		112755
neXtProt AC		NX_P61266
Human Synonyms		STX1B1, STX1B2
Human Chr (Location)		16p11.2; chr16:31000577-31021829 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(4) Gene trapped(4)
 

Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	intracellular protein transport, neurotransmitter transport, ...
Component	integral to membrane, membrane
Function	protein binding, protein domain specific binding, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (3)    Tissues (2)    Images (1)
Theiler Stages: 26

Assay Type	Results
Western blot	3

cDNA source data(2)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(2) cDNA(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031121 (Evidence)
Ensembl Gene Model	ENSMUSG00000030806 (Evidence)
Entrez Gene	56216 (Evidence)
DFCI	TC1595842
DoTS	DT.40167259
NIA Mouse Gene Index	U029309
Consensus CDS Project	CCDS40146.1
International Mouse Knockout Project Status	Stx1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031121	VEGA Gene Model | MGI Sequence Detail	20650	C57BL/6J
transcript	OTTMUST00000077102	VEGA | MGI Sequence Detail	4536	Not Applicable
polypeptide	OTTMUSP00000040686	VEGA | MGI Sequence Detail	288	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(58 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015709	Syntaxin-1
InterPro	IPR006012	Syntaxin/epimorphin, conserved site
InterPro	IPR006011	Syntaxin, N-terminal
InterPro	IPR000727	Target SNARE coiled-coil domain
InterPro	IPR010989	t-SNARE
Protein Ontology	PR:000015793	syntaxin-1B

References

(Earliest) J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
(Latest) J:193122 Zhou P, et al., Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J. 2013 Jan 9;32(1):159-71
All references(45)