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Stx1b
Gene Detail
Symbol

Name
ID
Stx1b
syntaxin 1B
MGI:1930705
Synonyms
Stx1b2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
69.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:127803900-127824549 bp, - strand
From VEGA annotation of GRCm38

  20650 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69375  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: syntaxin
Gene Tree: Stx1b

Human
homologs
Human Homolog STX1B, syntaxin 1B
NCBI Gene ID 112755
neXtProt AC  NX_P61266
Human Synonyms  STX1B1, STX1B2
Human Chr (Location)  16p11.2; chr16:30989256-31010508 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(4) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.
 
Interactions
Stx1b interacts with 334 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process intracellular protein transport, neurotransmitter transport, ...
Component endomembrane system, integral component of membrane, ...
Function protein binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (7)    Tissues (4)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 3
cDNA source data(2)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031121 (Evidence)
Ensembl Gene ModelENSMUSG00000030806 (Evidence)
Entrez Gene56216 (Evidence)
DFCITC1595842
DoTSDT.40167259
NIA Mouse Gene IndexU029309
Consensus CDS ProjectCCDS40146.1
International Mouse Knockout Project StatusStx1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031121 VEGA Gene Model | MGI Sequence Detail 20650 C57BL/6J ±  kb
transcript OTTMUST00000077102 VEGA | MGI Sequence Detail 4536 Not Applicable 
polypeptide OTTMUSP00000040686 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(12) UniProt(1)
Polymorphisms
SNPs within 2kb(72 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015793 syntaxin-1B
References
(Earliest) J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
(Latest) J:202743 Arancillo M, et al., Titration of Syntaxin1 in mammalian synapses reveals multiple roles in vesicle docking, priming, and release probability. J Neurosci. 2013 Oct 16;33(42):16698-714
All references(50)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory