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Stx1b Gene Detail
Summary
  • Symbol
    Stx1b
  • Name
    syntaxin 1B
  • Synonyms
    Stx1b2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930705
    NCBI Gene: 56216
  • Gene Overview
    MyGene.info: STX1B
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127803900-127824531 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 69.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930705
protein coding gene Chr7:127803900-127824549 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033056
protein coding gene Chr7:132178443-132199265 (-)
A/J MGP_AJ_G0033039
protein coding gene Chr7:128643274-128665337 (-)
AKR/J MGP_AKRJ_G0032971
protein coding gene Chr7:131969835-131992585 (-)
BALB/cJ MGP_BALBcJ_G0033040
protein coding gene Chr7:128297396-128318215 (-)
C3H/HeJ MGP_C3HHeJ_G0032754
protein coding gene Chr7:131872644-131892844 (-)
C57BL/6NJ MGP_C57BL6NJ_G0033549
protein coding gene Chr7:137328714-137349567 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030522
protein coding gene Chr7:129845310-129863973 (-)
CAST/EiJ MGP_CASTEiJ_G0032083
protein coding gene Chr7:123669278-123690355 (-)
CBA/J MGP_CBAJ_G0032727
protein coding gene Chr7:141976649-142009216 (-)
DBA/2J MGP_DBA2J_G0032879
protein coding gene Chr7:126624793-126645934 (-)
FVB/NJ MGP_FVBNJ_G0032832
protein coding gene Chr7:126480105-126504499 (-)
LP/J MGP_LPJ_G0032973
protein coding gene Chr7:133653852-133674281 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032864
protein coding gene Chr7:143061208-143085545 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033569
protein coding gene Chr7:130962153-130985218 (-)
PWK/PhJ MGP_PWKPhJ_G0031790
protein coding gene Chr7:119636615-119658456 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031636
protein coding gene Chr7:117766264-117787417 (-)
WSB/EiJ MGP_WSBEiJ_G0032195
protein coding gene Chr7:131927056-131952426 (-)



Homology
more
  • Human Ortholog
    STX1B, syntaxin 1B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STX1B, syntaxin 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GEFSP9, STX1B1, STX1B2
  • Links
    NCBI Gene ID: 112755
    neXtProt AC: NX_P61266
    UniProt: P61266

  • Chr Location
    16p11.2; chr16:30989256-31010638 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele that encodes an 'open' syntaxin-1B protein conformation are viable but display severe ataxia, reduced chromaffin vesicle docking, accelerated synaptic vesicle fusion, and lethal epileptic seizures after 2 weeks of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56216 NCBI Gene Model | MGI Sequence Detail 20632 C57BL/6J ±  kb
    transcript NM_024414 RefSeq | MGI Sequence Detail 1574 Not Specified  
    polypeptide P61264 UniProt | EBI | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 4
    References
    more
    • Summaries
      All 59
      Developmental Gene Expression 19
      Gene Ontology 14
      Phenotypes 13
    • Earliest
      J:119891 Yang SN, et al., Syntaxin 1 interacts with the L(D) subtype of voltage-gated Ca(2+) channels in pancreatic beta cells. Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10164-9
    • Latest
      J:264021 Ros O, et al., A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLoS Genet. 2018 Jun;14(6):e1007432

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory