About   Help   FAQ
Srd5a3
Gene Detail
 Symbol
Name
ID
Srd5a3
steroid 5 alpha-reductase 3
MGI:1930252
Synonyms 1110025P14Rik, D730040M03Rik, Srd5a2l
Feature Type protein coding gene
Genetic Map
Chromosome 5
40.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:76140271-76155504 bp, + strand
From VEGA annotation of GRCm38

  15234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Srd5a3

Human
homologs
Human Homolog SRD5A3, steroid 5 alpha-reductase 3
NCBI Gene ID 79644
neXtProt AC  NX_Q9H8P0
Human Synonyms  CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Human Chr (Location)  4q12; chr4:55346221-55373100 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human SRD5A3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality between E11.5 and E13.5 with open neural tubes, failure to turn, dilated hearts, and ventral body wall defects.
 
Interactions
Srd5a3 interacts with 109 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process dolichol-linked oligosaccharide biosynthetic process, dolichol metabolic process, ...
Component cytoplasm, endoplasmic reticulum, ...
Function 3-oxo-5-alpha-steroid 4-dehydrogenase activity, cholestenone 5-alpha-reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (112)   
Theiler Stages: 13, 17, 20, 22, 23, 28
Assay TypeResults
RNA in situ 94
In situ reporter (knock in) 21
RT-PCR 2
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000025182 (Evidence)
Ensembl Gene ModelENSMUSG00000029233 (Evidence)
Entrez Gene57357 (Evidence)
DFCITC1577809, TC1655081, TC1670632, TC1683233
DoTSDT.40161590, DT.87072367, DT.94191820, DT.97408887
NIA Mouse Gene IndexU005698
EC1.3.1.22, 1.3.1.94
Consensus CDS ProjectCCDS19358.1
International Mouse Knockout Project StatusSrd5a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025182 VEGA Gene Model | MGI Sequence Detail 15234 C57BL/6J ±  kb
transcript OTTMUST00000061989 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000030509 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology PR:000015610 polyprenol reductase
References (Earliest) J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:1923565, MGI:1925601, MGI:2141123, MGI:2141254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory