Srd5a3
Gene Detail

Symbol Name ID

Srd5a3 steroid 5 alpha-reductase 3 MGI:1930252

Synonyms

1110025P14Rik, D730040M03Rik, Srd5a2l

Feature Type

protein coding gene

Genetic Map

Chromosome 5

40.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:76140271-76155504 bp, + strand From VEGA annotation of GRCm38   15234 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Srd5a3 ± 2 cM)

Gene Tree: Srd5a3

Human ortholog

SRD5A3 steroid 5 alpha-reductase 3 NCBI Gene ID 79644
Human Synonyms: CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
Human Chr4:56212409-56237866 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human SRD5A3 (2)

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Mice homozygous for a gene trapped allele exhibit embryonic lethality between E11.5 and E13.5 with open neural tubes, failure to turn, dilated hearts, and ventral body wall defects.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	dolichol-linked oligosaccharide biosynthetic process, dolichol metabolic process, ...
Component	cytoplasm, endoplasmic reticulum, ...
Function	3-oxo-5-alpha-steroid 4-dehydrogenase activity, cholestenone 5-alpha-reductase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (112)   
Theiler Stages: 13, 17, 20, 22, 23, 28

Assay Type	Results
RNA in situ	94
In situ reporter (knock in)	21
RT-PCR	2

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000025182 (Evidence)
Ensembl Gene Model	ENSMUSG00000029233 (Evidence)
Entrez Gene	57357 (Evidence)
DFCI	TC1577809, TC1655081, TC1670632, TC1683233
DoTS	DT.40161590, DT.87072367, DT.94191820, DT.97408887
NIA Mouse Gene Index	U005698
EC	1.3.1.22, 1.3.1.94
Consensus CDS Project	CCDS19358.1
International Mouse Knockout Project Status	Srd5a3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025182	VEGA Gene Model | MGI Sequence Detail	15234	C57BL/6J
transcript	OTTMUST00000061989	VEGA | MGI Sequence Detail	1747	Not Applicable
polypeptide	OTTMUSP00000030509	VEGA | MGI Sequence Detail	330	Not Applicable

All sequences(64) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(124 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001104	3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology	PR:000015610	3-oxo-5-alpha-steroid 4-dehydrogenase 3

References

(Earliest) J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)

Other accession IDs

MGI:1923565, MGI:1925601, MGI:2141123, MGI:2141254