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Srd5a3 Gene Detail
Summary
  • Symbol
    Srd5a3
  • Name
    steroid 5 alpha-reductase 3
  • Synonyms
    1110025P14Rik, D730040M03Rik, Srd5a2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930252
    NCBI Gene: 57357
  • Gene Overview
    MyGene.info: SRD5A3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:76140271-76155504 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15234 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 40.50 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SRD5A3, steroid 5 alpha-reductase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRD5A3, steroid 5 alpha-reductase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1
  • Links
    NCBI Gene ID: 79644
    neXtProt AC: NX_Q9H8P0
    UniProt: Q9H8P0

  • Chr Location
    4q12; chr4:55346114-55373100 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 41385
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SRD5A3
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human SRD5A3 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality between E11.5 and E13.5 with open neural tubes, failure to turn, dilated hearts, and ventral body wall defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025182 VEGA Gene Model | MGI Sequence Detail 15234 C57BL/6J ±  kb
    transcript OTTMUST00000061989 VEGA | MGI Sequence Detail 1747 Not Applicable  
    polypeptide OTTMUSP00000030509 VEGA | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      221 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 16
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1923565, MGI:1925601, MGI:2141123, MGI:2141254
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:246066 Sundberg JP, et al., Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PLoS One. 2017;12(7):e0180682

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory