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Srd5a3
Gene Detail
Symbol

Name
ID
Srd5a3
steroid 5 alpha-reductase 3
MGI:1930252
Synonyms
1110025P14Rik, D730040M03Rik, Srd5a2l
Feature Type
protein coding gene
Genetic Map
Chromosome 5
40.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:76140271-76155504 bp, + strand
From VEGA annotation of GRCm38

  15234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41385  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SRD5A3
Gene Tree: Srd5a3

Human
homologs
SRD5A3, steroid 5 alpha-reductase 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 79644
neXtProt AC: NX_Q9H8P0

Human Synonyms: CDG1P, CDG1Q, KRIZI, SRD5A2L, SRD5A2L1

Human Chr (Location): 4q12; chr4:55346221-55373100 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SRD5A3

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trapped allele exhibit embryonic lethality between E11.5 and E13.5 with open neural tubes, failure to turn, dilated hearts, and ventral body wall defects.
 
Interactions
Srd5a3 interacts with 109 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (117)    Tissues (112)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
In situ reporter (knock in) 21
RT-PCR 2
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase srd5a3 ; ZFIN srd5a3    NEW 
Molecular
reagents
All nucleic(16) cDNA(15) Primer pair(1)
Microarray probesets(8)
Other database
links
VEGA Gene Model OTTMUSG00000025182 (Evidence)
Ensembl Gene Model ENSMUSG00000029233 (Evidence)
Entrez Gene 57357 (Evidence)
DFCI TC1577809, TC1655081, TC1670632, TC1683233
DoTS DT.40161590, DT.87072367, DT.94191820, DT.97408887
NIA Mouse Gene Index U005698
EC 1.3.1.22, 1.3.1.94
Consensus CDS Project CCDS19358.1
International Mouse Phenotyping Consortium Status Srd5a3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025182 VEGA Gene Model | MGI Sequence Detail 15234 C57BL/6J ±  kb
transcript OTTMUST00000061989 VEGA | MGI Sequence Detail 1747 Not Applicable 
polypeptide OTTMUSP00000030509 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001104 3-oxo-5-alpha-steroid 4-dehydrogenase, C-terminal
Protein Ontology PR:000015610 polyprenol reductase
References
(Earliest) J:66232 Wilsbacher LD, et al., The mouse clock locus: sequence and comparative analysis of 204 Kb from mouse chromosome 5. Genome Res. 2000 Dec;10(12):1928-40
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:1923565, MGI:1925601, MGI:2141123, MGI:2141254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory