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Maged1 Gene Detail
Summary
  • Symbol
    Maged1
  • Name
    melanoma antigen, family D, 1
  • Synonyms
    2810433C11Rik, 5430405L04Rik, Dlxin-1, DXBwg1492e, MAGE-D1, Nrage
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930187
    NCBI Gene: 94275
  • Gene Overview
    MyGene.info: MAGED1
Location & Maps
more
  • Sequence Map
    ChrX:94535474-94542143 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6670 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 41.56 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAGED1, MAGE family member D1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    MAGED1, MAGE family member D1
    Orthology source: HomoloGene
  • Synonyms
    DLXIN-1, NRAGE
  • Links
    NCBI Gene ID: 9500
    neXtProt AC: NX_Q9Y5V3

  • Chr Location
    Xp11.23; chrX:51803059-51902354 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
Homozygous null mice display defects in apoptotic signaling affecting hair cycling and neuronal physiology. Mice homozygous for a different knock-out allele exhibit hypoactivity, decreased exploration, social withdrawal, anhedonia, behavioral despair andaltered serotonin levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018127 VEGA Gene Model | MGI Sequence Detail 6670 C57BL/6J ±  kb
transcript OTTMUST00000043761 VEGA | MGI Sequence Detail 2821 Not Applicable  
polypeptide OTTMUSP00000019650 VEGA | MGI Sequence Detail 775 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    19 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000010075 melanoma-associated antigen D1
  • InterPro Domains
    IPR002190 MAGE homology domain
    IPR030083 Melanoma-associated antigen D1
Molecular
Reagents
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  • All nucleic 642
    cDNA 634
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-35682, MGI:107217, MGI:1917220, MGI:1922987
References
more
  • Summaries
    All 58
    Developmental Gene Expression 16
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:226720 Liu M, et al., MAGED1 Is a Negative Regulator of Bone Remodeling in Mice. Am J Pathol. 2015 Oct;185(10):2653-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory