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Maged1
Gene Detail
Symbol

Name
ID
Maged1
melanoma antigen, family D, 1
MGI:1930187
Synonyms
2810433C11Rik, 5430405L04Rik, Dlxin-1, DXBwg1492e, MAGE-D1, Nrage
Feature Type
protein coding gene
Genetic Map
Chromosome X
41.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:94535474-94542143 bp, - strand
From VEGA annotation of GRCm38

  6670 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5077  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Maged1

Human
homologs
Human Homolog MAGED1, melanoma antigen family D, 1
NCBI Gene ID 9500
neXtProt AC  NX_Q9Y5V3
Human Synonyms  DLXIN-1, NRAGE
Human Chr (Location)  Xp11.23; chrX:51803059-51902354 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
 
Homozygous null mice display defects in apoptotic signaling affecting hair cycling and neuronal physiology. Mice homozygous for a different knock-out allele exhibit hypoactivity, decreased exploration, social withdrawal, anhedonia, behavioral despair and altered serotonin levels.
 
Interactions
Maged1 interacts with 93 markers (Mir24-1, Mir24-2, Mir25, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (338)    Tissues (44)    Images (27)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 323
Northern blot 6
Western blot 7
cDNA source data(634)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(638) cDNA(634) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000018127 (Evidence)
Ensembl Gene ModelENSMUSG00000025151 (Evidence)
Entrez Gene94275 (Evidence)
UniGene27578
DFCITC1573807, TC1586595, TC1603190, TC1624356
DoTSDT.101176239, DT.101311988, DT.99867690, DT.97395855, DT.537334, DT.94206146
NIA Mouse Gene IndexU039537
Consensus CDS ProjectCCDS30280.1
International Mouse Knockout Project StatusMaged1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018127 VEGA Gene Model | MGI Sequence Detail 6670 C57BL/6J ±  kb
transcript OTTMUST00000043761 VEGA | MGI Sequence Detail 2821 Not Applicable 
polypeptide OTTMUSP00000019650 VEGA | MGI Sequence Detail 775 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(11)
Polymorphisms
SNPs within 2kb(19 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002190 MAGE protein
Protein Ontology PR:000010075 melanoma-associated antigen D1
References
(Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:187993 Dombret C, et al., Loss of Maged1 results in obesity, deficits of social interactions, impaired sexual behavior and severe alteration of mature oxytocin production in the hypothalamus. Hum Mol Genet. 2012 Nov 1;21(21):4703-17
All references(60)
Other
accession IDs
MGD-MRK-35682, MGI:107217, MGI:1917220, MGI:1922987

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory