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Nme3 Gene Detail
Summary
  • Symbol
    Nme3
  • Name
    NME/NM23 nucleoside diphosphate kinase 3
  • Synonyms
    1810009F08Rik, DR-nm23, Ndk3, Nm23-M3, non-metastatic cells 3, protein expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930182
    NCBI Gene: 79059
  • Gene Overview
    MyGene.info: NME3
Location & Maps
more
  • Sequence Map
    Chr17:24896500-24897522 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1023 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NME3, NME/NM23 nucleoside diphosphate kinase 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NME3, NME/NM23 nucleoside diphosphate kinase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    c371H6.2, DR-nm23, NDPKC, NDPK-C, NM23H3, NM23-H3
  • Links
    NCBI Gene ID: 4832
    neXtProt AC: NX_Q13232

  • Chr Location
    16p13.3; chr16:1770320-1771758 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    5 phenotype references
  • All Mutations and Alleles
    4
  • Gene trapped
    1
  • Targeted
    2
  • Transgenic
    1
  • Incidental Mutations
Mice heterozygous for a knock-out allele exhibit transmission distortion ratio of the t-haplotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030474 VEGA Gene Model | MGI Sequence Detail 1023 C57BL/6J ±  kb
transcript OTTMUST00000075445 VEGA | MGI Sequence Detail 715 Not Applicable  
polypeptide OTTMUSP00000039553 VEGA | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    23 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    cDNA 58
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914950, MGI:2146840
References
more
  • Summaries
    All 38
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
  • Latest
    J:183481 Bauer H, et al., The nucleoside diphosphate kinase gene Nme3 acts as quantitative trait locus promoting non-Mendelian inheritance. PLoS Genet. 2012 Mar;8(3):e1002567

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory