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Nme3 Gene Detail
Summary
  • Symbol
    Nme3
  • Name
    NME/NM23 nucleoside diphosphate kinase 3
  • Synonyms
    1810009F08Rik, DR-nm23, Ndk3, Nm23-M3, non-metastatic cells 3, protein expressed in
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930182
    NCBI Gene: 79059
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25115474-25116496 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930182
 protein coding gene Chr17:25115474-25116505 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023332
 protein coding gene Chr17:23921830-23922862 (+)
A/J MGP_AJ_G0023292
 protein coding gene Chr17:23258619-23259651 (+)
AKR/J MGP_AKRJ_G0023259
 protein coding gene Chr17:23347118-23348150 (+)
BALB/cJ MGP_BALBcJ_G0023297
 protein coding gene Chr17:23459161-23460193 (+)
C3H/HeJ MGP_C3HHeJ_G0023057
 protein coding gene Chr17:23712456-23713488 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023740
 protein coding gene Chr17:24984810-24985832 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021215
 protein coding gene Chr17:20718858-20719886 (+)
CAST/EiJ MGP_CASTEiJ_G0022559
 protein coding gene Chr17:23566996-23568028 (+)
CBA/J MGP_CBAJ_G0023033
 protein coding gene Chr17:25829219-25830251 (+)
DBA/2J MGP_DBA2J_G0023162
 protein coding gene Chr17:22851456-22852488 (+)
FVB/NJ MGP_FVBNJ_G0023132
 protein coding gene Chr17:22571813-22572845 (+)
LP/J MGP_LPJ_G0023239
 protein coding gene Chr17:24227093-24228125 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023151
 protein coding gene Chr17:25518507-25519539 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023778
 protein coding gene Chr17:23631623-23632655 (+)
PWK/PhJ MGP_PWKPhJ_G0022308
 protein coding gene Chr17:21606772-21607794 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022126
 protein coding gene Chr17:21695928-21696964 (+)
WSB/EiJ MGP_WSBEiJ_G0022622
 protein coding gene Chr17:23704192-23705224 (+)



Homology
more
  • Human Ortholog
    NME3, NME/NM23 nucleoside diphosphate kinase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NME3, NME/NM23 nucleoside diphosphate kinase 3
  • Synonyms
    c371H6.2, DR-nm23, NDPKC, NDPK-C, NM23H3, NM23-H3
  • Links
    NCBI Gene ID: 4832
    neXtProt AC: NX_Q13232
    UniProt: Q13232

  • Chr Location
    16p13.3; chr16:1770320-1771561 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from multigenic genotypes
    5 phenotype references
Mice heterozygous for a knock-out allele exhibit transmission distortion ratio of the t-haplotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    148
  • cDNA Data
    60
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073435 Ensembl Gene Model | MGI Sequence Detail 1023 C57BL/6J ±  kb
transcript ENSMUST00000024978 Ensembl | MGI Sequence Detail 715 Not Applicable  
polypeptide ENSMUSP00000024978 Ensembl | MGI Sequence Detail 169 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    cDNA 60
    Primer pair 1
    Other 4

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914950, MGI:2146840
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 5
  • Earliest
    J:63450 Kargul GJ, et al., Eleven densely clustered genes, six of them novel, in 176 kb of mouse t-complex DNA. Genome Res. 2000 Jul;10(7):916-23
  • Latest
    J:275567 Zurkirchen L, et al., Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner. Nat Commun. 2019 May 16;10(1):2192
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory