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Pvrl3
Gene Detail
Symbol

Name
ID
Pvrl3
poliovirus receptor-related 3
MGI:1930171
Synonyms
2610301B19Rik, 3000002N23Rik, 4921513D19Rik, nectin-3
Feature Type
protein coding gene
Genetic Map
Chromosome 16
30.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:46387706-46498525 bp, - strand
From VEGA annotation of GRCm38

  110820 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9162  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: poliovirus receptor-related protein
Gene Tree: Pvrl3

Human
homologs
Human Homolog PVRL3, poliovirus receptor-related 3
NCBI Gene ID 25945
neXtProt AC  NX_Q9NQS3
Human Synonyms  CD113, CDW113, NECTIN-3, PPR3, PRR3, PVRR3
Human Chr (Location)  3q13; chr3:111071759-111194170 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit male infertility and eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses.
 
Interactions
Pvrl3 interacts with 529 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process cell adhesion, fertilization, ...
Component apical junction complex, cell-cell adherens junction, ...
Function cell adhesion molecule binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (156)    Tissues (78)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 155
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) cDNA(19)
Microarray probesets(12)
Other database
links
VEGA Gene ModelOTTMUSG00000014968 (Evidence)
Ensembl Gene ModelENSMUSG00000022656 (Evidence)
Entrez Gene58998 (Evidence)
DFCITC1601155, TC1600463, TC1579820, TC1636621
DoTSDT.94258817, DT.97366359, DT.94244390, DT.94244392, DT.94244388, DT.91347958, DT.55118291, DT.528780, DT.101266350
NIA Mouse Gene IndexU037085
PDB3AXA
Consensus CDS ProjectCCDS28204.1, CCDS28205.1, CCDS28206.1
International Mouse Knockout Project StatusPvrl3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014968 VEGA Gene Model | MGI Sequence Detail 110820 C57BL/6J ±  kb
transcript OTTMUST00000035532 VEGA | MGI Sequence Detail 3062 Not Applicable 
polypeptide OTTMUSP00000015912 VEGA | MGI Sequence Detail 549 Not Applicable 

For the selected sequences
All sequences(106) RefSeq(14) UniProt(11)
Polymorphisms
SNPs within 2kb(897 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000002070 poliovirus receptor-related protein 3
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:206763 Gan Q, et al., Pax6 mediates ss-catenin signaling for self-renewal and neurogenesis by neocortical radial glial stem cells. Stem Cells. 2014 Jan;32(1):45-58
All references(64)
Other
accession IDs
MGI:1914402, MGI:1918158, MGI:1919634, MGI:2146332, MGI:2146547, MGI:2146649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory