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Popdc2 Gene Detail
Summary
  • Symbol
    Popdc2
  • Name
    popeye domain containing 2
  • Synonyms
    Pop2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930150
    NCBI Gene: 64082
  • Gene Overview
    MyGene.info: POPDC2
Location & Maps
more
  • Sequence Map
    Chr16:38362209-38378216 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16008 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.79 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    POPDC2, popeye domain containing 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POPDC2, popeye domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POP2
  • Links
    NCBI Gene ID: 64091
    neXtProt AC: NX_Q9HBU9

  • Chr Location
    3q13.33; chr3:119642055-119660590 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Targeted
    3
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit sinus brachycardia in response to physical or mental stress and catecholamines with a compact sinoatrial node.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024842 VEGA Gene Model | MGI Sequence Detail 16008 C57BL/6J ±  kb
transcript OTTMUST00000061198 VEGA | MGI Sequence Detail 2169 Not Applicable  
polypeptide OTTMUSP00000029965 VEGA | MGI Sequence Detail 371 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    101 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000013028 popeye domain-containing protein 2
  • InterPro Domains
    IPR018490 Cyclic nucleotide-binding-like
    IPR006916 Popeye protein
Molecular
Reagents
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  • All nucleic 34
    cDNA 29
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:2146588
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:63597 Andree B, et al., Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Dev Biol. 2000 Jul 15;223(2):371-82
  • Latest
    J:233976 Dupays L, et al., Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell Rep. 2015 Oct 6;13(1):183-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory