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Popdc2 Gene Detail
Summary
  • Symbol
    Popdc2
  • Name
    popeye domain containing 2
  • Synonyms
    Pop2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930150
    NCBI Gene: 64082
  • Gene Overview
    MyGene.info: POPDC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38362209-38378216 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1930150
protein coding gene Chr16:38362160-38378216 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022813
protein coding gene Chr16:36887734-36903780 (+)
A/J MGP_AJ_G0022778
protein coding gene Chr16:35058940-35073238 (+)
AKR/J MGP_AKRJ_G0022750
protein coding gene Chr16:36390408-36406251 (+)
BALB/cJ MGP_BALBcJ_G0022779
protein coding gene Chr16:35178062-35192419 (+)
C3H/HeJ MGP_C3HHeJ_G0022543
protein coding gene Chr16:36494576-36508955 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023226
protein coding gene Chr16:37726941-37742949 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020741
protein coding gene Chr16:35434135-35449426 (+)
CAST/EiJ MGP_CASTEiJ_G0022069
protein coding gene Chr16:36650121-36665662 (+)
CBA/J MGP_CBAJ_G0022514
protein coding gene Chr16:39387624-39403131 (+)
DBA/2J MGP_DBA2J_G0022646
protein coding gene Chr16:34940739-34955096 (+)
FVB/NJ MGP_FVBNJ_G0022621
protein coding gene Chr16:34971315-34986357 (+)
LP/J MGP_LPJ_G0022714
protein coding gene Chr16:36569301-36585763 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022640
protein coding gene Chr16:38505134-38521480 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023241
protein coding gene Chr16:36352844-36367195 (+)
PWK/PhJ MGP_PWKPhJ_G0021809
protein coding gene Chr16:35355111-35371434 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021640
protein coding gene Chr16:36249386-36264710 (+)
WSB/EiJ MGP_WSBEiJ_G0022113
protein coding gene Chr16:36422734-36439983 (+)



Homology
more
  • Human Ortholog
    POPDC2, popeye domain containing 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    POPDC2, popeye domain containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    POP2
  • Links
    NCBI Gene ID: 64091
    neXtProt AC: NX_Q9HBU9
    UniProt: Q9HBU9

  • Chr Location
    3q13.33; chr3:119642052-119660590 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit sinus brachycardia in response to physical or mental stress and catecholamines with a compact sinoatrial node.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022803 Ensembl Gene Model | MGI Sequence Detail 16008 C57BL/6J ±  kb
    transcript ENSMUST00000023494 Ensembl | MGI Sequence Detail 2169 Not Applicable  
    polypeptide ENSMUSP00000023494 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR018490 Cyclic nucleotide-binding-like
      IPR006916 Popeye protein
    Molecular
    Reagents
    less
    • All nucleic 35
      cDNA 30
      Primer pair 4
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2146588
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 5
    • Earliest
      J:63597 Andree B, et al., Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Dev Biol. 2000 Jul 15;223(2):371-82
    • Latest
      J:233976 Dupays L, et al., Sequential Binding of MEIS1 and NKX2-5 on the Popdc2 Gene: A Mechanism for Spatiotemporal Regulation of Enhancers during Cardiogenesis. Cell Rep. 2015 Oct 6;13(1):183-95

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory