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Mcm3ap Gene Detail
Summary
  • Symbol
    Mcm3ap
  • Name
    minichromosome maintenance complex component 3 associated protein
  • Synonyms
    GANP, mKIAA0572
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930089
    NCBI Gene: 54387
  • Gene Overview
    MyGene.info: MCM3AP
Location & Maps
more
  • Sequence Map
    Chr10:76468971-76515856 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      46886 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MCM3AP, minichromosome maintenance complex component 3 associated protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MCM3AP, minichromosome maintenance complex component 3 associated protein
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GANP, MAP80, SAC3
  • Links
    NCBI Gene ID: 8888
    neXtProt AC: NX_O60318

  • Chr Location
    21q22.3; chr21:46235125-46286559 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2902
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: MCM3AP
  • Gene Tree
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    18
  • Chemically induced (other)
    1
  • Gene trapped
    11
  • Targeted
    6
  • Genomic Mutations
    5 involving Mcm3ap
  • Incidental Mutations
Mice homozygous for a null allele die by E12.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001150 Ensembl Gene Model | MGI Sequence Detail 46886 C57BL/6J ±  kb
transcript ENSMUST00000170795 Ensembl | MGI Sequence Detail 6382 Not Applicable  
polypeptide ENSMUSP00000125960 Ensembl | MGI Sequence Detail 1971 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    232 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000010244 germinal-center associated nuclear protein
  • InterPro Domains
    IPR031910 Germinal-centre associated nuclear protein, CID domain
    IPR031907 Germinal-centre associated nuclear protein, MCM3AP domain
    IPR031908 Germinal-centre associated nuclear protein, nucleoporin homology domain
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR005062 SAC3/GANP/THP3
Molecular
Reagents
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  • All nucleic 125
    Genomic 1
    cDNA 122
    Primer pair 2

    Microarray probesets 3
References
more
  • Summaries
    All 38
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 4
    Phenotypes 23
  • Earliest
    J:62649 Kuwahara K, et al., A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication. Blood. 2000 Apr 1;95(7):2321-8
  • Latest
    J:205742 Singh SK, et al., GANP regulates recruitment of AID to immunoglobulin variable regions by modulating transcription and nucleosome occupancy. Nat Commun. 2013;4:1830

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory