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Fads2
Gene Detail
Symbol

Name
ID
Fads2
fatty acid desaturase 2
MGI:1930079
Synonyms
2900042M13Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.36 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr19:10064164-10101503 bp, - strand
From NCBI annotation of GRCm38

  37340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fatty acid desaturase/sphingolipid desaturase
Gene Tree: Fads2

Human
homologs
Human Homolog FADS2, fatty acid desaturase 2
NCBI Gene ID 9415
neXtProt AC  NX_O95864
Human Synonyms  D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13
Human Chr (Location)  11q12.2; chr11:61816203-61867354 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele display absence of long-chain polyunsaturated fatty acids, infertility, arrest of spermiogenesis and folliculogenesis, and impaired platelet function.
 
Interactions
Fads2 interacts with 24 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process fatty acid biosynthetic process, fatty acid metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function acyl-CoA desaturase activity, heme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (94)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(91)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024665 (Evidence)
Entrez Gene56473 (Evidence)
UniGene38901
DFCITC1580003, TC1643209
DoTSDT.528476
NIA Mouse Gene IndexU038795
EC1.14.19.-
Consensus CDS ProjectCCDS29571.1
International Mouse Knockout Project StatusFads2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56473 NCBI Gene Model | MGI Sequence Detail 37340 C57BL/6J ±  kb
transcript NM_019699 RefSeq | MGI Sequence Detail 1508 Not Specified 
polypeptide Q9Z0R9 UniProt | EBI | MGI Sequence Detail 444 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(326 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001199 Cytochrome b5-like heme/steroid binding domain
InterPro IPR005804 Fatty acid desaturase, type 1
InterPro IPR012171 Fatty acid/sphingolipid desaturase
Protein Ontology PR:000007318 fatty acid desaturase 2
Graphical View of Protein Domain Structure
References
(Earliest) J:51797 Cho HP, et al., Cloning, expression, and nutritional regulation of the mammalian Delta-6 desaturase. J Biol Chem. 1999 Jan 1;274(1):471-7
(Latest) J:211959 Stoffel W, et al., Obesity resistance and deregulation of lipogenesis in Delta6-fatty acid desaturase (FADS2) deficiency. EMBO Rep. 2014 Jan;15(1):110-20
All references(43)
Other
accession IDs
MGI:1920207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory