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Piwil2
Gene Detail
Symbol

Name
ID
Piwil2
piwi-like RNA-mediated gene silencing 2
MGI:1930036
Synonyms
mili, Miwi like
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70372480-70429094 bp, - strand
From Ensembl annotation of GRCm38

  56615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIWIL2
Protein SuperFamily: piwi protein
Gene Tree: Piwil2

Human
homologs
PIWIL2, piwi-like RNA-mediated gene silencing 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55124
neXtProt AC: NX_Q8TC59

Human Synonyms: CT80, HILI, mili, PIWIL1L

Human Chr (Location): 8p21.3; chr8:22275297-22357568 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased testis weight, azoospermia, and male infertility associated with a complete arrest of spermatogenesis and increased apoptotic cell death during the early prophase of the first meiosis.
 
Interactions
Piwil2 interacts with 266 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell differentiation, DNA methylation involved in gamete generation, ...
Component chromatoid body, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (89)    Tissues (68)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 40
Northern blot 11
RT-PCR 35
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase piwil2 ; ZFIN piwil2    NEW 
Molecular
reagents
All nucleic(27) cDNA(24) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033644 (Evidence)
Entrez Gene 57746 (Evidence)
UniGene 85253
DFCI TC1584316
DoTS DT.40169773
NIA Mouse Gene Index U035745
PDB 4B9W
Consensus CDS Project CCDS27252.1
International Mouse Phenotyping Consortium Status Piwil2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033644 Ensembl Gene Model | MGI Sequence Detail 56615 C57BL/6J ±  kb
transcript ENSMUST00000048129 Ensembl | MGI Sequence Detail 4913 Not Applicable 
polypeptide ENSMUSP00000047385 Ensembl | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR003165 Stem cell self-renewal protein Piwi
Protein Ontology PR:000012763 piwi-like protein 2
References
(Earliest) J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
(Latest) J:213579 Liao HF, et al., DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory