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Piwil2
Gene Detail
 Symbol
Name
ID
Piwil2
piwi-like RNA-mediated gene silencing 2
MGI:1930036
Synonyms mili, Miwi like
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70372480-70429094 bp, - strand
From NCBI annotation of GRCm38

  56615 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: piwi protein
Gene Tree: Piwil2

Human
homologs
Human Homolog PIWIL2, piwi-like RNA-mediated gene silencing 2
NCBI Gene ID 55124
neXtProt AC  NX_Q8TC59
Human Synonyms  CT80, HILI, mili, PIWIL1L
Human Chr (Location)  8p21.3; chr8:22275297-22357568 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit decreased testis weight, azoospermia, and male infertility associated with a complete arrest of spermatogenesis and increased apoptotic cell death during the early prophase of the first meiosis.
 
Interactions
Piwil2 interacts with 267 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell differentiation, DNA methylation involved in gamete generation, ...
Component chromatoid body, cytoplasm, ...
Function mRNA binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (27 records)
Data Summary: Results (89)    Tissues (68)    Images (18)
Theiler Stages: 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 40
Northern blot 11
RT-PCR 35
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(23) Primer pair(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033644 (Evidence)
Entrez Gene57746 (Evidence)
UniGene85253
DFCITC1584316
DoTSDT.40169773
NIA Mouse Gene IndexU035745
PDB4B9W
Consensus CDS ProjectCCDS27252.1
International Mouse Knockout Project StatusPiwil2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57746 NCBI Gene Model | MGI Sequence Detail 56615 C57BL/6J ±  kb
transcript NM_021308 RefSeq | MGI Sequence Detail 4913 Not Specified 
polypeptide Q8CDG1 UniProt | EBI | MGI Sequence Detail 971 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(6) UniProt(1)
Polymorphisms SNPs within 2kb(429 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003100 Argonaute/Dicer protein, PAZ
InterPro IPR012337 Ribonuclease H-like domain
InterPro IPR003165 Stem cell self-renewal protein Piwi
Protein Ontology PR:000012763 piwi-like protein 2
Graphical View of Protein Domain Structure
References (Earliest) J:68614 Wang PJ, et al., An abundance of X-linked genes expressed in spermatogonia. Nat Genet. 2001 Apr;27(4):422-6
(Latest) J:204889 Nolde MJ, et al., Piwi genes are dispensable for normal hematopoiesis in mice. PLoS One. 2013;8(8):e71950
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory