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Cst10
Gene Detail
Symbol

Name
ID
Cst10
cystatin 10 (chondrocytes)
MGI:1930004
Synonyms
DD72
Feature Type
protein coding gene
Genetic Map
Chromosome 2
73.80 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:149405057-149410293 bp, + strand
From VEGA annotation of GRCm38

  5237 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque

Gene Tree: Cst10

Human
homologs
Human Homolog CST5, cystatin D
NCBI Gene ID 1473
neXtProt AC  NX_P28325
Human Chr (Location)  20p11.21; chr20:23875935-23879743 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display reduced chondrocyte calcification during endochondral ossification both under physiological and pathological conditions.
 
Interactions
Cst10 interacts with 43 markers (Mir7-2, Mir7b, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process cell maturation, chondrocyte differentiation, ...
Component cytosol, extracellular region, ...
Function cysteine-type endopeptidase inhibitor activity
External Resources: FuncBase
Expression
cDNA source data(34)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(34)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000015751 (Evidence)
Ensembl Gene ModelENSMUSG00000033156 (Evidence)
Entrez Gene58214 (Evidence)
UniGene117117
DFCITC1584452
DoTSDT.483557
NIA Mouse Gene IndexU002610
Consensus CDS ProjectCCDS16853.1
International Mouse Knockout Project StatusCst10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015751 VEGA Gene Model | MGI Sequence Detail 5237 C57BL/6J ±  kb
transcript OTTMUST00000037405 VEGA | MGI Sequence Detail 804 Not Applicable 
polypeptide OTTMUSP00000016759 VEGA | MGI Sequence Detail 148 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(4)
Polymorphisms
SNPs within 2kb(50 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027214 Cystatin
InterPro IPR001713 Proteinase inhibitor I25A, stefin A
InterPro IPR000010 Proteinase inhibitor I25, cystatin
InterPro IPR020381 Proteinase inhibitor I25, cystatin, conserved region
InterPro IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Protein Ontology PR:000005967 cystatin-D
References
(Earliest) J:60993 Shoemaker K, et al., Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T. Gene. 2000 Mar 7;245(1):103-8
(Latest) J:137304 Frygelius J, et al., The reproductive tissue specific cystatin subgroup of genes: expression during gonadal development in wildtype and testatin knockout animals. Sex Dev. 2007;1(6):363-72
All references(23)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory