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Cst10 Gene Detail
Summary
  • Symbol
    Cst10
  • Name
    cystatin 10 (chondrocytes)
  • Synonyms
    DD72
  • Feature Type
    protein coding gene
  • IDs
    MGI:1930004
    NCBI Gene: 58214
  • Gene Overview
    MyGene.info: CST5
Location & Maps
more
  • Sequence Map
    Chr2:149405057-149410293 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5237 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 73.80 cM, cytoband G
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    CST5, cystatin D
  • Vertebrate Orthologs
    4
  • Human Ortholog
    CST5, cystatin D
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 1473
    neXtProt AC: NX_P28325

  • Chr Location
    20p11.21; chr20:23875935-23879743 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Cst10
  • Incidental Mutations
Mice homozygous for a knock-out allele display reduced chondrocyte calcification during endochondral ossification both under physiological and pathological conditions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015751 VEGA Gene Model | MGI Sequence Detail 5237 C57BL/6J ±  kb
transcript OTTMUST00000037406 VEGA | MGI Sequence Detail 729 Not Applicable  
polypeptide OTTMUSP00000016760 VEGA | MGI Sequence Detail 148 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    50 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR027214 Cystatin
    IPR000010 Cystatin domain
    IPR001713 Proteinase inhibitor I25A, stefin A
    IPR020381 Proteinase inhibitor I25, cystatin, conserved region
    IPR018073 Proteinase inhibitor I25, cystatin, conserved site
Molecular
Reagents
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  • All nucleic 34
    cDNA 34

    Microarray probesets 2
References
more
  • Summaries
    All 20
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:60993 Shoemaker K, et al., Molecular cloning, chromosome mapping and characterization of a testis-specific cystatin-like cDNA, cystatin T. Gene. 2000 Mar 7;245(1):103-8
  • Latest
    J:137304 Frygelius J, et al., The reproductive tissue specific cystatin subgroup of genes: expression during gonadal development in wildtype and testatin knockout animals. Sex Dev. 2007;1(6):363-72

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory