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Klk11 Gene Detail
Summary
  • Symbol
    Klk11
  • Name
    kallikrein related-peptidase 11
  • Synonyms
    2310015I08Rik, hippostasin, Prss20, TLSP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929977
    NCBI Gene: 56538
  • Gene Overview
    MyGene.info: KLK11
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:43774617-43779263 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 28.26 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929977
protein coding gene Chr7:43774604-43779263 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032140
protein coding gene Chr7:43815140-43820907 (+)
A/J MGP_AJ_G0032125
protein coding gene Chr7:42904556-42909215 (+)
AKR/J MGP_AKRJ_G0032055
protein coding gene Chr7:44288660-44293319 (+)
BALB/cJ MGP_BALBcJ_G0032130
protein coding gene Chr7:43020735-43025639 (+)
C3H/HeJ MGP_C3HHeJ_G0031846
protein coding gene Chr7:44792752-44798888 (+)
C57BL/6NJ MGP_C57BL6NJ_G0032614
protein coding gene Chr7:46011464-46028914 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029637
protein coding gene Chr7:45038607-45043191 (+)
CAST/EiJ MGP_CASTEiJ_G0031176
protein coding gene Chr7:35982675-35988965 (+)
CBA/J MGP_CBAJ_G0031815
protein coding gene Chr7:47484523-47491764 (+)
DBA/2J MGP_DBA2J_G0031964
protein coding gene Chr7:42710725-42716058 (+)
FVB/NJ MGP_FVBNJ_G0031925
protein coding gene Chr7:42422387-42427056 (+)
LP/J MGP_LPJ_G0032043
protein coding gene Chr7:44542807-44548519 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031961
protein coding gene Chr7:46409942-46416306 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0032634
protein coding gene Chr7:43415609-43420262 (+)
PWK/PhJ MGP_PWKPhJ_G0030897
protein coding gene Chr7:36161233-36166034 (+)
SPRET/EiJ MGP_SPRETEiJ_G0030736
protein coding gene Chr7:31445787-31450385 (+)
WSB/EiJ MGP_WSBEiJ_G0031290
protein coding gene Chr7:43962221-43968214 (+)



Homology
more
  • Human Ortholog
    KLK11, kallikrein related peptidase 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KLK11, kallikrein related peptidase 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRSS20, TLSP
  • Links
    NCBI Gene ID: 11012
    neXtProt AC: NX_Q9UBX7
    UniProt: Q9UBX7

  • Chr Location
    19q13.41; chr19:51022231-51028034 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 56538 NCBI Gene Model | MGI Sequence Detail 4647 C57BL/6J ±  kb
transcript NM_001177373 RefSeq | MGI Sequence Detail 1319 C57BL/6  
polypeptide Q9QYN3 UniProt | EBI | MGI Sequence Detail 276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 2
Other
Accession IDs
less
MGI:1913805
References
more
  • Summaries
    All 24
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:65795 Mitsui S, et al., cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)(1). Biochim Biophys Acta. 2000 Nov 15;1494(1-2):206-10
  • Latest
    J:251299 Nimpong JA, et al., Deficiency of KLF4 compromises the lung function in an acute mouse model of allergic asthma. Biochem Biophys Res Commun. 2017 Nov 4;493(1):598-603

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory