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Klk11
Gene Detail
Symbol

Name
ID
Klk11
kallikrein related-peptidase 11
MGI:1929977
Synonyms
2310015I08Rik, hippostasin, Prss20, TLSP
Feature Type
protein coding gene
Genetic Map
Chromosome 7
28.26 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:43774617-43779258 bp, + strand
From Ensembl annotation of GRCm38

  4642 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 3 western clawed frog

HCOP human homology predictions: KLK11
Protein SuperFamily: trypsin
Gene Tree: Klk11

Human
homologs
KLK11, kallikrein-related peptidase 11
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 11012
neXtProt AC: NX_Q9UBX7

Human Synonyms: PRSS20, TLSP

Human Chr (Location): 19q13.33; chr19:51022231-51028034 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Klk11 interacts with 64 markers (Mir7-1, Mir26a-1, Mir26a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process proteolysis
Component extracellular exosome, extracellular region, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(10)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(11) cDNA(10) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000067616 (Evidence)
Entrez Gene 56538 (Evidence)
UniGene 154276
DFCI TC1586339
DoTS DT.50316147, DT.91338283
NIA Mouse Gene Index U267856
EC 3.4.21.-
Consensus CDS Project CCDS39935.1, CCDS52227.1
International Mouse Phenotyping Consortium Status Klk11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000067616 Ensembl Gene Model | MGI Sequence Detail 4642 C57BL/6J ±  kb
transcript ENSMUST00000080211 Ensembl | MGI Sequence Detail 1294 Not Applicable 
polypeptide ENSMUSP00000079101 Ensembl | MGI Sequence Detail 276 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(4)
Polymorphisms
SNPs within 2kb(97 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000009408 kallikrein-11
References
(Earliest) J:65795 Mitsui S, et al., cDNA cloning and tissue-specific splicing variants of mouse hippostasin/TLSP (PRSS20)(1). Biochim Biophys Acta. 2000 Nov 15;1494(1-2):206-10
(Latest) J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
All references(25)
Other
accession IDs
MGI:1913805

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory