About   Help   FAQ
Bcam
Gene Detail
 Symbol
Name
ID
Bcam
basal cell adhesion molecule
MGI:1929940
Synonyms 1200005K12Rik, B-CAM, Lu
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19756131-19771016 bp, - strand
From VEGA annotation of GRCm38

  14886 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Bcam

Human
homologs
Human Homolog BCAM, basal cell adhesion molecule (Lutheran blood group)
NCBI Gene ID 4059
neXtProt AC  NX_P50895
Human Synonyms  AU, CD239, LU, MSK19
Human Chr (Location)  19q13.2; chr19:44809059-44821421 (+)  GRCh38
Alleles
and
phenotypes
All alleles(15) : Gene trapped(13) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a null allele exhibit glomeruli abnormalities and increased thickness and disorganization of intestinal smooth muscle.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process cell adhesion, cell-matrix adhesion
Component cell surface, extracellular vesicular exosome, ...
Function laminin binding, laminin receptor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28
Assay TypeResults
Northern blot 12
cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(103) cDNA(102) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000031720 (Evidence)
Ensembl Gene ModelENSMUSG00000002980 (Evidence)
Entrez Gene57278 (Evidence)
UniGene29236
DFCITC1575031, TC1592560, TC1593491, TC1771643
DoTSDT.101214139, DT.101367534, DT.490178
NIA Mouse Gene IndexU028240
Consensus CDS ProjectCCDS39803.1
International Mouse Knockout Project StatusBcam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031720 VEGA Gene Model | MGI Sequence Detail 14886 C57BL/6J ±  kb
transcript OTTMUST00000078567 VEGA | MGI Sequence Detail 2429 Not Applicable 
polypeptide OTTMUSP00000041791 VEGA | MGI Sequence Detail 622 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(191 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR003598 Immunoglobulin subtype 2
Protein Ontology PR:000001143 basal cell adhesion molecule
References (Earliest) J:61456 Rahuel C, et al., Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene. Immunogenetics. 1999 Dec;50(5-6):271-7
(Latest) J:204904 Kikkawa Y, et al., The lutheran/basal cell adhesion molecule promotes tumor cell migration by modulating integrin-mediated cell attachment to laminin-511 protein. J Biol Chem. 2013 Oct 25;288(43):30990-1001
All references(40)
Other
accession IDs
MGI:1918955

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory