Bcam
Gene Detail

Symbol Name ID

Bcam basal cell adhesion molecule MGI:1929940

Synonyms

1200005K12Rik, B-CAM, Lu

Feature Type

protein coding gene

Genetic Map

Chromosome 7

9.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:19756131-19771016 bp, - strand From VEGA annotation of GRCm38   14886 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21149  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Bcam

Human homologs

Human Homolog		BCAM, basal cell adhesion molecule (Lutheran blood group)
NCBI Gene ID		4059
neXtProt AC		NX_P50895
Human Synonyms		AU, CD239, LU, MSK19
Human Chr (Location)		19q13.2; chr19:45312316-45324678 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(2) Gene trapped(13)
 

A gene trap insertion into an intron of this gene results in no obvious phenotype. Mice homozygous for a null allele exhibit glomeruli abnormalities and increased thickness and disorganization of intestinal smooth muscle.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	cell adhesion, cell-matrix adhesion
Component	cell surface, integral to membrane, ...
Function	laminin binding, laminin receptor activity

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (12)    Tissues (12)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	12

cDNA source data(102)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(103) cDNA(102) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031720 (Evidence)
Ensembl Gene Model	ENSMUSG00000002980 (Evidence)
Entrez Gene	57278 (Evidence)
UniGene	29236
DFCI	TC1575031, TC1592560, TC1593491, TC1771643
DoTS	DT.101214139, DT.101367534, DT.490178
NIA Mouse Gene Index	U028240
Consensus CDS Project	CCDS39803.1
International Mouse Knockout Project Status	Bcam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031720	VEGA Gene Model | MGI Sequence Detail	14886	C57BL/6J
transcript	OTTMUST00000078567	VEGA | MGI Sequence Detail	2429	Not Applicable
polypeptide	OTTMUSP00000041791	VEGA | MGI Sequence Detail	622	Not Applicable

All sequences(49) RefSeq(2) UniProt(5)

Polymorphisms

PCR(1) : SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR003598	Immunoglobulin subtype 2
Protein Ontology	PR:000001143	lutheran blood group glycoprotein

References

(Earliest) J:61456 Rahuel C, et al., Characterization of a mouse liminin receptor gene homologous to the human blood group Lutheran gene. Immunogenetics. 1999 Dec;50(5-6):271-7
(Latest) J:187297 Ritie L, et al., Abnormal Wnt and PI3Kinase signaling in the malformed intestine of lama5 deficient mice. PLoS One. 2012;7(5):e37710
All references(39)

Other accession IDs

MGI:1918955