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Bcl11b
Gene Detail
 Symbol
Name
ID
Bcl11b
B cell leukemia/lymphoma 11B
MGI:1929913
Synonyms 9130430L19Rik, B630002E05Rik, COUP-TF interacting protein 2, CTIP2, Rit1
Feature Type protein coding gene
Genetic Map
Chromosome 12
59.10 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr12:107910403-108003602 bp, - strand
From VEGA annotation of GRCm38

  93200 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Bcl11b

Human
homologs
Human Homolog BCL11B, B-cell CLL/lymphoma 11B (zinc finger protein)
NCBI Gene ID 64919
neXtProt AC  NX_Q9C0K0
Human Synonyms  ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP2, CTIP-2, hRIT1-alpha, RIT1, ZNF856B
Human Chr (Location)  14q32.2; chr14:99169287-99271713 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(10)
Incidental mutations (data from Mutagenetix , APF )
 
Animals homozygous for a mutation of this gene are born with open eyes, exhibit abnormalities of the thymus, and die within 1 day after birth. Mice heterozygous for a hypomorphic allele and a knock-out allele exhibit lethality at weaning due to maxillary incisor hyperplasia.
 
Interactions
Bcl11b interacts with 461 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process alpha-beta T cell differentiation, axonogenesis, ...
Component intracellular, neuron part, ...
Function metal ion binding, nucleic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (140 records)
Data Summary: Results (136)    Tissues (109)    Images (62)
Theiler Stages: 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 42
RNA in situ 79
Northern blot 1
Western blot 2
RT-PCR 12
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(64) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019485 (Evidence)
Ensembl Gene ModelENSMUSG00000048251 (Evidence)
Entrez Gene58208 (Evidence)
UniGene392694
DFCITC1583807, TC1595108, TC1598959, TC1615876, TC1625299
DoTSDT.486535, DT.101329370, DT.101721120, DT.528032
NIA Mouse Gene IndexU034331
Consensus CDS ProjectCCDS36552.1, CCDS36553.1, CCDS70419.1
International Mouse Knockout Project StatusBcl11b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019485 VEGA Gene Model | MGI Sequence Detail 93200 C57BL/6J ±  kb
transcript OTTMUST00000046516 VEGA | MGI Sequence Detail 8111 Not Applicable 
polypeptide OTTMUSP00000021002 VEGA | MGI Sequence Detail 884 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(20) UniProt(2)
Polymorphisms SNPs within 2kb(814 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000004691 B-cell lymphoma/leukemia 11B
References (Earliest) J:61589 Avram D, et al., Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000 Apr 7;275(14):10315-22
(Latest) J:210221 Mandai K, et al., Linx Mediates Interaxonal Interactions and Formation of the Internal Capsule. Neuron. 2014 Jun 11;
All references(200)
Other
accession IDs
MGI:1924922, MGI:1925932, MGI:2144864

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory