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Bcl11b Gene Detail
Summary
  • Symbol
    Bcl11b
  • Name
    B cell leukemia/lymphoma 11B
  • Synonyms
    9130430L19Rik, B630002E05Rik, COUP-TF interacting protein 2, CTIP2, Rit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929913
    NCBI Gene: 58208
  • Gene Overview
    MyGene.info: BCL11B
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:107910403-108003602 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.10 cM, cytoband F1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    811 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929913
protein coding gene Chr12:107910403-108004139 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020099
protein coding gene Chr12:109984199-110085474 (-)
A/J MGP_AJ_G0020053
protein coding gene Chr12:105841021-105935251 (-)
AKR/J MGP_AKRJ_G0020029
protein coding gene Chr12:108900274-109001889 (-)
BALB/cJ MGP_BALBcJ_G0020039
protein coding gene Chr12:106243213-106338701 (-)
C3H/HeJ MGP_C3HHeJ_G0019841
protein coding gene Chr12:109346053-109441906 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020484
protein coding gene Chr12:113353436-113458930 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018096
protein coding gene Chr12:102378008-102470412 (-)
CAST/EiJ MGP_CASTEiJ_G0019383
protein coding gene Chr12:104248155-104350572 (-)
CBA/J MGP_CBAJ_G0019808
protein coding gene Chr12:117871692-117973366 (-)
DBA/2J MGP_DBA2J_G0019925
protein coding gene Chr12:105359755-105453962 (-)
FVB/NJ MGP_FVBNJ_G0019910
protein coding gene Chr12:104135781-104231194 (-)
LP/J MGP_LPJ_G0020000
protein coding gene Chr12:109845504-109953276 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019948
protein coding gene Chr12:121110223-121207902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020513
protein coding gene Chr12:108354535-108453724 (-)
PWK/PhJ MGP_PWKPhJ_G0019142
protein coding gene Chr12:99971965-100066905 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018946
protein coding gene Chr12:102569103-102665110 (-)
WSB/EiJ MGP_WSBEiJ_G0019440
protein coding gene Chr12:109294206-109394420 (-)



Homology
more
  • Human Ortholog
    BCL11B, BCL11B, BAF complex component
  • Vertebrate Orthologs
    11
  • Human Ortholog
    BCL11B, BCL11B, BAF complex component
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP2, CTIP-2, hRIT1-alpha, IDDFSTA, IMD49, RIT1, ZNF856B
  • Links
    NCBI Gene ID: 64919
    neXtProt AC: NX_Q9C0K0
    UniProt: Q9C0K0

  • Chr Location
    14q32.2; chr14:99169287-99271713 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10974
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: BCL11B
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    60 phenotypes from 7 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    50 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Animals homozygous for a mutation of this gene are born with open eyes, exhibit abnormalities of the thymus, and die within 1 day after birth. Mice heterozygous for a hypomorphic allele and a knock-out allele exhibit lethality at weaning due to maxillaryincisor hyperplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048251 Ensembl Gene Model | MGI Sequence Detail 93200 C57BL/6J ±  kb
    transcript ENSMUST00000066060 Ensembl | MGI Sequence Detail 8111 Not Applicable  
    polypeptide ENSMUSP00000068258 Ensembl | MGI Sequence Detail 884 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 65
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1924922, MGI:1925932, MGI:2144864
    References
    more
    • Summaries
      All 412
      Developmental Gene Expression 335
      Gene Ontology 22
      Phenotypes 50
    • Earliest
      J:61589 Avram D, et al., Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors. J Biol Chem. 2000 Apr 7;275(14):10315-22
    • Latest
      J:266542 Hasenpusch-Theil K, et al., Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression. Development. 2018 Aug 20;145(17)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory