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Cend1 Gene Detail
Summary
  • Symbol
    Cend1
  • Name
    cell cycle exit and neuronal differentiation 1
  • Synonyms
    1500001H12Rik, BM88
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929898
    NCBI Gene: 57754
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:141426446-141429491 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3046 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 86.77 cM, cytoband F5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    CEND1, cell cycle exit and neuronal differentiation 1
  • Vertebrate Orthologs
    4
  • Human Ortholog
    CEND1, cell cycle exit and neuronal differentiation 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BM88
  • Links
    NCBI Gene ID: 51286
    neXtProt AC: NX_Q8N111
    UniProt: Q8N111

  • Chr Location
    11p15.5; chr11:787110-790126 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display impaired cerebellar development with defects in granule cell proliferation and migration and purkinje cell arborization. These defects result in a thin cerebellar molecular layer and impaired coordination in adults.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034077 VEGA Gene Model | MGI Sequence Detail 3046 C57BL/6J ±  kb
    transcript OTTMUST00000086113 VEGA | MGI Sequence Detail 1672 Not Applicable  
    polypeptide OTTMUSP00000046571 VEGA | MGI Sequence Detail 149 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      17 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000005322 cell cycle exit and neuronal differentiation protein 1
    • InterPro Domains
      IPR020162 Cell cycle exit/neuronal differentiation protein 1
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 24
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916208, MGI:2141931
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 5
    • Earliest
      J:65007 Cattanach BM, et al., Two imprinted gene mutations: three phenotypes. Hum Mol Genet. 2000 Sep 22;9(15):2263-73
    • Latest
      J:197136 Weng L, et al., Loss of Ahi1 Affects Early Development by Impairing BM88/Cend1-Mediated Neuronal Differentiation. J Neurosci. 2013 May 8;33(19):8172-8184

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory