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Clstn1 Gene Detail
Summary
  • Symbol
    Clstn1
  • Name
    calsyntenin 1
  • Synonyms
    1810034E21Rik, alcadein alpha, calsyntenin-1, Cst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929895
    NCBI Gene: 65945
  • Gene Overview
    MyGene.info: CLSTN1
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:149586468-149648899 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 79.91 cM, cytoband E1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    439 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929895
protein coding gene Chr4:149586468-149648899 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029143
protein coding gene Chr4:153448506-153525449 (+)
A/J MGP_AJ_G0029108
protein coding gene Chr4:147043532-147111546 (+)
AKR/J MGP_AKRJ_G0029056
protein coding gene Chr4:151065378-151147808 (+)
BALB/cJ MGP_BALBcJ_G0029124
protein coding gene Chr4:147543029-147608691 (+)
C3H/HeJ MGP_C3HHeJ_G0028845
protein coding gene Chr4:151626192-151701484 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029573
protein coding gene Chr4:158987697-159063569 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026819
protein coding gene Chr4:139454389-139526553 (+)
CAST/EiJ MGP_CASTEiJ_G0028258
protein coding gene Chr4:148860274-148939968 (+)
CBA/J MGP_CBAJ_G0028807
protein coding gene Chr4:163646358-163721187 (+)
DBA/2J MGP_DBA2J_G0028956
protein coding gene Chr4:147143075-147204775 (+)
FVB/NJ MGP_FVBNJ_G0028920
protein coding gene Chr4:146260458-146332320 (+)
LP/J MGP_LPJ_G0029046
protein coding gene Chr4:153364681-153452916 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028947
protein coding gene Chr4:166881024-166958722 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029605
protein coding gene Chr4:151566986-151637593 (+)
PWK/PhJ MGP_PWKPhJ_G0027978
protein coding gene Chr4:143150080-143221772 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027812
protein coding gene Chr4:145815718-145894213 (+)
WSB/EiJ MGP_WSBEiJ_G0028338
protein coding gene Chr4:151719950-151792219 (+)



Homology
more
  • Human Ortholog
    CLSTN1, calsyntenin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLSTN1, calsyntenin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALC-ALPHA, alcalpha1, alcalpha2, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha
  • Links
    NCBI Gene ID: 22883
    neXtProt AC: NX_O94985
    UniProt: O94985

  • Chr Location
    1p36.22; chr1:9729021-9824526 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8814
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CLSTN1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Juvenile mice homozygous for a null allele show reduced basal excitatory synaptic transmission, abnormal excitatory postsynaptic currents, enhanced NMDA receptor-dependent long term potentiation, and delayed dendritic spine maturation in CA1 hippocampal pyramidal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65945 NCBI Gene Model | MGI Sequence Detail 62432 C57BL/6J ±  kb
    transcript NM_023051 RefSeq | MGI Sequence Detail 4505 C57BL/6  
    polypeptide Q9EPL2 UniProt | EBI | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 207
      cDNA 207

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1921573
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:245526 Bibollet-Bahena O, et al., A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. PLoS One. 2017;12(5):e0177977

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory