Bin3 MGI Mouse Gene Detail - MGI:1929883

Symbol

Bin3
Name

bridging integrator 3
Synonyms

1700015F07Rik

Feature Type

protein coding gene
IDs

MGI:1929883
NCBI Gene: 57784
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr14:70337538-70375413 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.21 cM, cytoband D1
Mapping Data

2 experiments

SNPs within 2kb

206 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929883	protein coding gene	Chr14:70337538-70375655 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021529	protein coding gene	Chr14:64720270-64759356 (+)
A/J	MGP_AJ_G0021488	protein coding gene	Chr14:63363523-63401440 (+)
AKR/J	MGP_AKRJ_G0021464	protein coding gene	Chr14:65263268-65301236 (+)
BALB/cJ	MGP_BALBcJ_G0021494	protein coding gene	Chr14:63123333-63161641 (+)
C3H/HeJ	MGP_C3HHeJ_G0021271	protein coding gene	Chr14:64974360-65013908 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021933	protein coding gene	Chr14:67636620-67676033 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019473	protein coding gene	Chr14:61199869-61238779 (+)
CAST/EiJ	MGP_CASTEiJ_G0020788	protein coding gene	Chr14:61557252-61598040 (+)
CBA/J	MGP_CBAJ_G0021238	protein coding gene	Chr14:69749294-69790710 (+)
DBA/2J	MGP_DBA2J_G0021361	protein coding gene	Chr14:62744675-62782876 (+)
FVB/NJ	MGP_FVBNJ_G0021340	protein coding gene	Chr14:62172589-62211289 (+)
LP/J	MGP_LPJ_G0021432	protein coding gene	Chr14:65974950-66012327 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021369	protein coding gene	Chr14:68667116-68706172 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021957	protein coding gene	Chr14:64523442-64565188 (+)
PWK/PhJ	MGP_PWKPhJ_G0020532	protein coding gene	Chr14:59505962-59544813 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020365	protein coding gene	Chr14:60448841-60488077 (+)
WSB/EiJ	MGP_WSBEiJ_G0020841	protein coding gene	Chr14:64831132-64870402 (+)

Human Ortholog

BIN3, bridging integrator 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

BIN3, bridging integrator 3
Links

HGNC:1054

NCBI Gene ID: 55909

neXtProt AC: NX_Q9NQY0

UniProt: Q9NQY0
Chr Location

8p21.3; chr8:22620418-22669148 (-) GRCh38

MGI Vertebrate Homology

Bin3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: BIN3
Gene Tree

Bin3

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

4
Targeted

1
Genomic Mutations

1 involving Bin3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice develop juvenile cataracts characterized by defects in cytoskeletal filamentous actin organization, show a higher incidence of spontaneous lymphomas during aging, and display a greater sensitivity to lung adenocarcinoma formation in response to radiation or carcinogen treatment.

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All GO Annotations

18
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

732
Tissues

10
cDNA Data

55
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bin3

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All Sequences

60
RefSeq

18
UniProt

3
CCDS

CCDS27247.1

Ensembl

ENSMUSG00000022089 (Evidence)
NCBI Gene

57784

			Length	Strain/Species	Flank
genomic	57784	NCBI Gene Model \| MGI Sequence Detail	37876	C57BL/6J	± kb
transcript	NM_021328	RefSeq \| MGI Sequence Detail	1559	C57BL/6
polypeptide	Q9JI08	UniProt \| EBI \| MGI Sequence Detail	253	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004750 bridging integrator 3

(term hierarchy)
InterPro Domains

IPR027267 AH/BAR domain superfamily

IPR004148 BAR domain

IPR037428 Bridging integrator 3, BAR domain

IPR046982 Bridging integrator 3/RVS161-like

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All nucleic 58

cDNA 55

Primer pair 2

Other 1

Microarray probesets 2

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MGI:1916644

Summaries

All 36

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 9
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:307860 Choquet H, et al., A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nat Commun. 2021 Jun 14;12(1):3595

TSS for Bin3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr126398	Chr14:70337532-70337593 (+)	25 bp
Tssr126399	Chr14:70337611-70337628 (+)	82 bp
Tssr126400	Chr14:70367572-70367579 (+)	30,038 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23