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Bin3
Gene Detail
 Symbol
Name
ID
Bin3
bridging integrator 3
MGI:1929883
Synonyms 1700015F07Rik
Feature Type protein coding gene
Genetic Map
Chromosome 14
36.21 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70100145-70138191 bp, + strand
From Ensembl annotation of GRCm38

  38047 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5472  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Bin3

Human
homologs
Human Homolog BIN3, bridging integrator 3
NCBI Gene ID 55909
neXtProt AC  NX_Q9NQY0
Human Chr (Location)  8p21.3; chr8:22620418-22669148 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(4) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice develop juvenile cataracts characterized by defects in cytoskeletal filamentous actin organization, show a higher incidence of spontaneous lymphomas during aging, and display a greater sensitivity to lung adenocarcinoma formation in response to radiation or carcinogen treatment.
 
Interactions
Bin3 interacts with 176 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process barrier septum assembly, cell cycle, ...
Component actin filament, cytoplasm, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (8)   
Theiler Stages: 17, 24, 26, 27, 28
Assay TypeResults
RNA in situ 4
RT-PCR 20
cDNA source data(54)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(56) cDNA(54) Primer pair(1) Other(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000022089 (Evidence)
Entrez Gene57784 (Evidence)
UniGene24186
DFCITC1577877
NIA Mouse Gene IndexU015815
Consensus CDS ProjectCCDS27247.1
International Mouse Knockout Project StatusBin3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022089 Ensembl Gene Model | MGI Sequence Detail 38047 C57BL/6J ±  kb
transcript ENSMUST00000022680 Ensembl | MGI Sequence Detail 1712 Not Applicable 
polypeptide ENSMUSP00000022680 Ensembl | MGI Sequence Detail 253 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(8) UniProt(2)
Polymorphisms SNPs within 2kb(205 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027267 Arfaptin homology (AH) domain/BAR domain
InterPro IPR004148 BAR domain
Protein Ontology PR:000004750 bridging integrator 3
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:202230 Simionescu-Bankston A, et al., The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis. Dev Biol. 2013 Oct 1;382(1):160-71
All references(33)
Other
accession IDs
MGI:1916644

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory