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As3mt
Gene Detail
 Symbol
Name
ID
As3mt
arsenic (+3 oxidation state) methyltransferase
MGI:1929882
Synonyms 2310045H08Rik, Cyt19
Feature Type protein coding gene
Genetic Map
Chromosome 19
38.97 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:46707443-46741095 bp, + strand
From NCBI annotation of GRCm38

  33653 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10754  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 3 western clawed frog; 1 zebrafish

Protein SuperFamily: S-adenosyl-L-methionine dependent methyltransferase, YcgJ type
Gene Tree: As3mt

Human
homologs
Human Homolog AS3MT, arsenite methyltransferase
NCBI Gene ID 57412
neXtProt AC  NX_Q9HBK9
Human Synonyms  CYT19
Human Chr (Location)  10q24.32; chr10:102869453-102901899 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(5) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele have abnormalities in arsenic methylation and in the distribution/retention of orally administered arsenate.
 
Interactions
As3mt interacts with 65 markers (Mir7b, Mir10a, Mir23a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process arsonoacetate metabolic process, methylation, ...
Component cytoplasm, cytosol, ...
Function arsenite methyltransferase activity, methylarsonite methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(62)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) cDNA(63)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003559 (Evidence)
Entrez Gene57344 (Evidence)
UniGene28566
DFCITC1577474
DoTSDT.492642, DT.91340559
NIA Mouse Gene IndexU019533
EC2.1.1.137
Consensus CDS ProjectCCDS50458.1
International Mouse Knockout Project StatusAs3mt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57344 NCBI Gene Model | MGI Sequence Detail 33653 C57BL/6J ±  kb
transcript NM_020577 RefSeq | MGI Sequence Detail 1752 C57BL/6 
polypeptide Q91WU5 UniProt | EBI | MGI Sequence Detail 376 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(198 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026669 Arsenite methyltransferase
InterPro IPR025714 Methyltransferase domain
Protein Ontology PR:000004335 arsenite methyltransferase
Graphical View of Protein Domain Structure
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:199302 Veenvliet JV, et al., Specification of dopaminergic subsets involves interplay of En1 and Pitx3. Development. 2013 Aug;140(16):3373-84
All references(39)
Other
accession IDs
MGI:1913858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory