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Smoc2 Gene Detail
Summary
  • Symbol
    Smoc2
  • Name
    SPARC related modular calcium binding 2
  • Synonyms
    1700056C05Rik, 5430426J21Rik, Smoc2l
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929881
    NCBI Gene: 64074
  • Gene Overview
    MyGene.info: SMOC2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:14279506-14404790 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.95 cM, cytoband A2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    799 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929881
protein coding gene Chr17:14279490-14404790 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023164
protein coding gene Chr17:12098880-12227940 (+)
A/J MGP_AJ_G0023130
protein coding gene Chr17:11922466-12048015 (+)
AKR/J MGP_AKRJ_G0023100
protein coding gene Chr17:11820395-11947922 (+)
BALB/cJ MGP_BALBcJ_G0023132
protein coding gene Chr17:11744849-11875805 (+)
C3H/HeJ MGP_C3HHeJ_G0022893
protein coding gene Chr17:12009570-12137232 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023573
protein coding gene Chr17:12670872-12801115 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021085
protein coding gene Chr17:9960145-10083181 (+)
CAST/EiJ MGP_CASTEiJ_G0022408
protein coding gene Chr17:11930489-12060887 (+)
CBA/J MGP_CBAJ_G0022867
protein coding gene Chr17:13062429-13187416 (+)
DBA/2J MGP_DBA2J_G0023000
protein coding gene Chr17:11648144-11774082 (+)
FVB/NJ MGP_FVBNJ_G0022968
protein coding gene Chr17:11440054-11566719 (+)
LP/J MGP_LPJ_G0023074
protein coding gene Chr17:12045837-12181415 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022989
protein coding gene Chr17:12668927-12801792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023609
protein coding gene Chr17:12040187-12168249 (+)
PWK/PhJ MGP_PWKPhJ_G0022156
protein coding gene Chr17:11073115-11201875 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021986
protein coding gene Chr17:11024519-11149487 (+)
WSB/EiJ MGP_WSBEiJ_G0022469
protein coding gene Chr17:12359699-12487590 (+)



Homology
more
  • Human Ortholog
    SMOC2, SPARC related modular calcium binding 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    SMOC2, SPARC related modular calcium binding 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA270C4A.1, bA37D8.1, dJ421D16.1, DTDP1, MST117, MSTP117, MSTP140, SMAP2
  • Links
    NCBI Gene ID: 64094
    neXtProt AC: NX_Q9H3U7
    UniProt: Q9H3U7

  • Chr Location
    6q27; chr6:168441151-168667994 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SMOC2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one KO allele exhibit protection from induced kidney fibrosis and reduced interstitial myofibroblast accumulation. Another KO allele leads to shortening and widening of the skull.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023886 Ensembl Gene Model | MGI Sequence Detail 125285 C57BL/6J ±  kb
    transcript ENSMUST00000233344 Ensembl | MGI Sequence Detail 2817 Not Applicable  
    polypeptide ENSMUSP00000156572 Ensembl | MGI Sequence Detail 458 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 71
      cDNA 68
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918668, MGI:1920709, MGI:1935165
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 15
      Gene Ontology 5
      Phenotypes 6
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:255774 Marchant TW, et al., Canine Brachycephaly Is Associated with a Retrotransposon-Mediated Missplicing of SMOC2. Curr Biol. 2017 Jun 5;27(11):1573-1584.e6

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory