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Terf2ip Gene Detail
Summary
  • Symbol
    Terf2ip
  • Name
    telomeric repeat binding factor 2, interacting protein
  • Synonyms
    Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929871
    NCBI Gene: 57321
  • Gene Overview
    MyGene.info: TERF2IP
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:112011398-112020528 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9131 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.29 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRIP5, RAP1
  • Links
    NCBI Gene ID: 54386
    neXtProt AC: NX_Q9NYB0
    UniProt: Q9NYB0

  • Chr Location
    16q23.1; chr16:75647704-75657442 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000061808 VEGA Gene Model | MGI Sequence Detail 9131 C57BL/6J ±  kb
    transcript OTTMUST00000150837 VEGA | MGI Sequence Detail 3560 Not Applicable  
    polypeptide OTTMUSP00000078220 VEGA | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      71 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016237 telomeric repeat-binding factor 2-interacting protein 1
    • InterPro Domains
      IPR001357 BRCT domain
      IPR009057 Homeobox-like domain superfamily
      IPR015010 Rap1 Myb domain
      IPR021661 TRF2-interacting telomeric protein/Rap1, C-terminal
      IPR038104 TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 42

      Microarray probesets 3
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:243602 Liu H, et al., NLRP3 inflammasome induced liver graft injury through activation of telomere-independent RAP1/KC axis. J Pathol. 2017 Jul;242(3):284-296

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/19/2018
    MGI 6.12
    The Jackson Laboratory