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Terf2ip Gene Detail
Summary
  • Symbol
    Terf2ip
  • Name
    telomeric repeat binding factor 2, interacting protein
  • Synonyms
    Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929871
    NCBI Gene: 57321
  • Gene Overview
    MyGene.info: TERF2IP
Location & Maps
more
  • Sequence Map
    Chr8:112011359-112020528 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9170 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
    Orthology source: HomoloGene
  • Synonyms
    DRIP5, RAP1
  • Links
    NCBI Gene ID: 54386
    neXtProt AC: NX_Q9NYB0

  • Chr Location
    16q23.1; chr16:75647704-75657442 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57321 NCBI Gene Model | MGI Sequence Detail 9170 C57BL/6J ±  kb
transcript NM_020584 RefSeq | MGI Sequence Detail 3599 C57BL/6  
polypeptide Q91VL8 UniProt | EBI | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    71 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016237 telomeric repeat-binding factor 2-interacting protein 1
  • InterPro Domains
    IPR001357 BRCT domain
    IPR009057 Homeodomain-like
    IPR015010 Rap1 Myb domain
    IPR021661 TRF2-interacting telomeric protein/Rap1, C-terminal
Molecular
Reagents
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  • All nucleic 42
    cDNA 42

    Microarray probesets 3
References
more
  • Summaries
    All 33
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 9
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:217428 Zimmermann M, et al., TRF1 negotiates TTAGGG repeat-associated replication problems by recruiting the BLM helicase and the TPP1/POT1 repressor of ATR signaling. Genes Dev. 2014 Nov 15;28(22):2477-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory