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Terf2ip
Gene Detail
 Symbol
Name
ID
Terf2ip
telomeric repeat binding factor 2, interacting protein
MGI:1929871
Synonyms Rap1
Feature Type protein coding gene
Genetic Map
Chromosome 8
58.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:112011359-112020528 bp, + strand
From NCBI annotation of GRCm38

  9170 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10357  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: Telomeric repeat-binding factor 2-interacting protein 1 (TERF2ip)
Gene Tree: Terf2ip

Human
homologs
Human Homolog TERF2IP, telomeric repeat binding factor 2, interacting protein
NCBI Gene ID 54386
neXtProt AC  NX_Q9NYB0
Human Synonyms  DRIP5, RAP1
Human Chr (Location)  16q23.1; chr16:75647737-75657442 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.
 
Interactions
Terf2ip interacts with 234 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process negative regulation of DNA recombination at telomere, negative regulation of telomere maintenance, ...
Component chromosome, chromosome, telomeric region, ...
Function DNA binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (5)    Tissues (2)    Images (2)
Theiler Stages: 20, 28
Assay TypeResults
In situ reporter (knock in) 1
Western blot 4
cDNA source data(40)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(42) cDNA(42)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000033430 (Evidence)
Entrez Gene57321 (Evidence)
UniGene213064
DFCITC1576227, TC1588904
DoTSDT.101146233, DT.87068750, DT.91306497
NIA Mouse Gene IndexU009841
Consensus CDS ProjectCCDS52678.1
International Mouse Knockout Project StatusTerf2ip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57321 NCBI Gene Model | MGI Sequence Detail 9170 C57BL/6J ±  kb
transcript NM_020584 RefSeq | MGI Sequence Detail 3599 C57BL/6 
polypeptide Q91VL8 UniProt | EBI | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009057 Homeodomain-like
InterPro IPR021661 Rap1 - C-terminal
InterPro IPR015010 Rap1 Myb domain
Protein Ontology PR:000016237 telomeric repeat-binding factor 2-interacting protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:201813 Horn HF, et al., A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. J Cell Biol. 2013 Sep 30;202(7):1023-39
All references(34)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory