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Terf2ip Gene Detail
Summary
  • Symbol
    Terf2ip
  • Name
    telomeric repeat binding factor 2, interacting protein
  • Synonyms
    Rap1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929871
    NCBI Gene: 57321
  • Gene Overview
    MyGene.info: TERF2IP
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:112011398-112020528 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 58.29 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    71 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929871
protein coding gene Chr8:112011359-112020528 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034153
protein coding gene Chr8:114852211-114863343 (+)
A/J MGP_AJ_G0034133
protein coding gene Chr8:110163527-110172287 (+)
AKR/J MGP_AKRJ_G0034060
protein coding gene Chr8:113411053-113421215 (+)
BALB/cJ MGP_BALBcJ_G0034127
protein coding gene Chr8:110340875-110350742 (+)
C3H/HeJ MGP_C3HHeJ_G0033838
protein coding gene Chr8:114115507-114127844 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034647
protein coding gene Chr8:118861624-118870468 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031589
protein coding gene Chr8:103234190-103243389 (+)
CAST/EiJ MGP_CASTEiJ_G0033165
protein coding gene Chr8:113761637-113777623 (+)
CBA/J MGP_CBAJ_G0033811
protein coding gene Chr8:122960430-122969011 (+)
DBA/2J MGP_DBA2J_G0033967
protein coding gene Chr8:109435659-109444012 (+)
FVB/NJ MGP_FVBNJ_G0033910
protein coding gene Chr8:108419160-108427298 (+)
LP/J MGP_LPJ_G0034056
protein coding gene Chr8:115004152-115014648 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033957
protein coding gene Chr8:125790537-125800414 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034665
protein coding gene Chr8:113395551-113411076 (+)
PWK/PhJ MGP_PWKPhJ_G0032867
protein coding gene Chr8:109048527-109057392 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032707
protein coding gene Chr8:112048242-112056790 (+)
WSB/EiJ MGP_WSBEiJ_G0033281
protein coding gene Chr8:114086002-114096894 (+)



Homology
more
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TERF2IP, TERF2 interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DRIP5, RAP1
  • Links
    NCBI Gene ID: 54386
    neXtProt AC: NX_Q9NYB0
    UniProt: Q9NYB0

  • Chr Location
    16q23.1; chr16:75647704-75657442 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 3 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are fertile. Mice homozygous for a gene trapped allele die prior to E6.5 while heterozygous mice are resistant to LPS-induced mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033430 Ensembl Gene Model | MGI Sequence Detail 9131 C57BL/6J ±  kb
    transcript ENSMUST00000052138 Ensembl | MGI Sequence Detail 3560 Not Applicable  
    polypeptide ENSMUSP00000052170 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000016237 telomeric repeat-binding factor 2-interacting protein 1
    • InterPro Domains
      IPR001357 BRCT domain
      IPR009057 Homeobox-like domain superfamily
      IPR015010 Rap1 Myb domain
      IPR021661 TRF2-interacting telomeric protein/Rap1, C-terminal
      IPR038104 TRF2-interacting telomeric protein/Rap1, C-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 43

      Microarray probesets 3
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Gene Ontology 13
      Phenotypes 13
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:257125 Wong KHK, et al., Deletion of Rap1 disrupts redox balance and impairs endothelium-dependent relaxations. J Mol Cell Cardiol. 2018 Feb;115:1-9

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory