About   Help   FAQ
Take the Alliance for Genomic Resources User Survey
Dpysl5 Gene Detail
Summary
  • Symbol
    Dpysl5
  • Name
    dihydropyrimidinase-like 5
  • Synonyms
    CRAM, Crmp5, CRMP-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929772
    NCBI Gene: 65254
  • Gene Overview
    MyGene.info: DPYSL5
Location & Maps
more
  • Sequence Map
    Chr5:30711564-30799375 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      87812 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 16.80 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DPYSL5, dihydropyrimidinase like 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPYSL5, dihydropyrimidinase like 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRAM, CRMP5, CRMP-5, Ulip6
  • Links
    NCBI Gene ID: 56896
    neXtProt AC: NX_Q9BPU6

  • Chr Location
    2p23.3; chr2:26848101-26950351 (+)  GRCh38.p2
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    16
  • Chemically induced (other)
    2
  • Gene trapped
    8
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    6 involving Dpysl5
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for a knock-out allele exhibit limb grasping, abnormal Purkinje morphology, absent long term depression, and no response to BDNF.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    8
  • Tissues
    4
  • cDNA Data
    129
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022301 VEGA Gene Model | MGI Sequence Detail 87812 C57BL/6J ±  kb
transcript OTTMUST00000053133 VEGA | MGI Sequence Detail 5191 Not Applicable  
polypeptide OTTMUSP00000025246 VEGA | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    635 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006683 dihydropyrimidinase-related protein 5
  • InterPro Domains
    IPR006680 Amidohydrolase-related
    IPR030626 Dihydropyrimidinase-related protein 5
    IPR011778 Hydantoinase/dihydropyrimidinase
    IPR032466 Metal-dependent hydrolase
    IPR011059 Metal-dependent hydrolase, composite domain
Molecular
Reagents
less
  • All nucleic 132
    Genomic 2
    cDNA 130

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:65791 Diamond I, et al., Conditional gene expression in the epidermis of transgenic mice using the tetracycline-regulated transactivators tTA and rTA linked to the keratin 5 promoter. J Invest Dermatol. 2000 Nov;115(5):788-94
  • Latest
    J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory