Dpysl5 MGI Mouse Gene Detail - MGI:1929772 - dihydropyrimidinase-like 5

Dpysl5 Gene Detail

Symbol

Dpysl5
Name

dihydropyrimidinase-like 5
Synonyms

CRAM, Crmp5, CRMP-5

Feature Type

protein coding gene
IDs

MGI:1929772
NCBI Gene: 65254
Gene Overview

MyGene.info: DPYSL5

Sequence Map

Chr5:30711564-30799375 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

87812 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.80 cM, cytoband B1
Mapping Data

2 experiments

Human Ortholog

DPYSL5, dihydropyrimidinase like 5

Vertebrate Orthologs

10

Human Ortholog

DPYSL5, dihydropyrimidinase like 5
Orthology source: HomoloGene, HGNC
Synonyms

CRAM, CRMP5, CRMP-5, Ulip6
Links

HGNC:20637

NCBI Gene ID: 56896

neXtProt AC: NX_Q9BPU6

UniProt: Q9BPU6
Chr Location

2p23.3; chr2:26848101-26950351 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 41347
1 human;1 mouse;2 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: DPYSL5
Gene Tree

Dpysl5

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (other)

2
Gene trapped

8
Radiation induced

3
Spontaneous

1
Targeted

2
Genomic Mutations

6 involving Dpysl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele exhibit limb grasping, abnormal Purkinje morphology, absent long term depression, and no response to BDNF.

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All GO Annotations

10
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

8
Tissues

4
cDNA Data

129
Literature Summary

3

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpysl5

ZFIN dpysl5a, dpysl5b

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Dpysl5 interacts with 320 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

47
RefSeq

4
UniProt

2
CCDS

CCDS39047.1
UniGene

27732

			Length	Strain/Species	Flank
genomic	OTTMUSG00000022301	VEGA Gene Model \| MGI Sequence Detail	87812	C57BL/6J	± kb
transcript	OTTMUST00000053133	VEGA \| MGI Sequence Detail	5191	Not Applicable
polypeptide	OTTMUSP00000025246	VEGA \| MGI Sequence Detail	564	Not Applicable

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SNPs within 2kb

635 from dbSNP Build 142

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UniProt

2 Sequences
Protein Ontology

PR:000006683 dihydropyrimidinase-related protein 5

(term hierarchy)
InterPro Domains

IPR006680 Amidohydrolase-related

IPR030626 Dihydropyrimidinase-related protein 5

IPR011778 Hydantoinase/dihydropyrimidinase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain

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All nucleic 132

Genomic 2

cDNA 130

Microarray probesets 4

Summaries

All 51

Developmental Gene Expression 3

Diseases 1

Gene Ontology 5

Phenotypes 26
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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