Dpysl5 MGI Mouse Gene Detail - MGI:1929772 - dihydropyrimidinase-like 5

Symbol

Dpysl5
Name

dihydropyrimidinase-like 5
Synonyms

CRAM, Crmp5, CRMP-5

Feature Type

protein coding gene
IDs

MGI:1929772
NCBI Gene: 65254
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr5:30868908-30956713 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 16.80 cM, cytoband B1
Mapping Data

2 experiments

SNPs within 2kb

629 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929772	protein coding gene	Chr5:30868908-30956719 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029395	protein coding gene	Chr5:28665390-28753915 (+)
A/J	MGP_AJ_G0029361	protein coding gene	Chr5:27729516-27818976 (+)
AKR/J	MGP_AKRJ_G0029312	protein coding gene	Chr5:28880648-28967701 (+)
BALB/cJ	MGP_BALBcJ_G0029372	protein coding gene	Chr5:28254808-28342103 (+)
C3H/HeJ	MGP_C3HHeJ_G0029093	protein coding gene	Chr5:28872947-28962294 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029825	protein coding gene	Chr5:30440163-30532759 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0027063	protein coding gene	Chr5:25216062-25300589 (+)
CAST/EiJ	MGP_CASTEiJ_G0028504	protein coding gene	Chr5:27969862-28054892 (+)
CBA/J	MGP_CBAJ_G0029061	protein coding gene	Chr5:31007234-31103738 (+)
DBA/2J	MGP_DBA2J_G0029210	protein coding gene	Chr5:27916470-28003668 (+)
FVB/NJ	MGP_FVBNJ_G0029168	protein coding gene	Chr5:27328592-27416335 (+)
LP/J	MGP_LPJ_G0029295	protein coding gene	Chr5:29124675-29216854 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029197	protein coding gene	Chr5:31908986-31995233 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029859	protein coding gene	Chr5:28381310-28471283 (+)
PWK/PhJ	MGP_PWKPhJ_G0028228	protein coding gene	Chr5:27030383-27116444 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0028059	protein coding gene	Chr5:27729106-27817495 (+)
WSB/EiJ	MGP_WSBEiJ_G0028584	protein coding gene	Chr5:28451472-28536055 (+)

Human Ortholog

DPYSL5, dihydropyrimidinase like 5

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DPYSL5, dihydropyrimidinase like 5
Synonyms

CRAM, CRMP5, CRMP-5, CV2, RTSC4, Ulip6
Links

HGNC:20637

NCBI Gene ID: 56896

neXtProt AC: NX_Q9BPU6

UniProt: Q9BPU6
Chr Location

2p23.3; chr2:26848101-26950351 (+) GRCh38.p7

Alliance of Genome Resources

Dpysl5 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: DPYSL5
Gene Tree

Dpysl5

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References

1 with disease annotations

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

2
Gene trapped

6
Radiation induced

2
Spontaneous

1
Targeted

2
Genomic Mutations

5 involving Dpysl5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available

Mice homozygous for a knock-out allele exhibit limb grasping, abnormal Purkinje morphology, absent long term depression, and no response to BDNF.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

724
Tissues

37
cDNA Data

131
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dpysl5

ZFIN dpysl5a, dpysl5b

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Dpysl5 interacts with 320 markers (Mir7-2, Mir7b, Mir9-1, ...) View All

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All Sequences

56
RefSeq

6
UniProt

2
CCDS

CCDS39047.1, CCDS89896.1

Ensembl

ENSMUSG00000029168 (Evidence)
NCBI Gene

65254

Representative Sequences				Length	Strain/Species	Flank
	genomic	65254	NCBI Gene Model \| MGI Sequence Detail	87806	C57BL/6J	± kb

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UniProt

2 Sequences
Protein Ontology

PR:000006683 dihydropyrimidinase-related protein 5

(term hierarchy)
InterPro Domains

IPR006680 Amidohydrolase-related

IPR030626 Dihydropyrimidinase-related protein 5

IPR011778 Hydantoinase/dihydropyrimidinase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain superfamily

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All nucleic 135

Genomic 3

cDNA 132

Microarray probesets 4

Summaries

All 56

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
Latest

J:295576 Lin YS, et al., Collapsin response mediator protein 5 (CRMP5) causes social deficits and accelerates memory loss in an animal model of Alzheimer's disease. Neuropharmacology. 2019 Oct;157:107673

TSS for Dpysl5:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr45608	Chr5:30868921-30868930 (+)	18 bp
Tssr45609	Chr5:30868934-30868941 (+)	30 bp
Tssr45610	Chr5:30868946-30868956 (+)	43 bp
Tssr45611	Chr5:30869193-30869249 (+)	313 bp
Tssr45612	Chr5:30903454-30903460 (+)	34,549 bp
Tssr45613	Chr5:30935443-30935465 (+)	66,546 bp
Tssr45614	Chr5:30936206-30936232 (+)	67,311 bp
Tssr45615	Chr5:30954231-30954258 (+)	85,337 bp
Tssr45616	Chr5:30954531-30954549 (+)	85,632 bp
Tssr45617	Chr5:30954872-30954884 (+)	85,970 bp
Tssr45618	Chr5:30955236-30955243 (+)	86,332 bp
Tssr45619	Chr5:30955414-30955431 (+)	86,515 bp
Tssr45620	Chr5:30955610-30955670 (+)	86,732 bp
Tssr45621	Chr5:30955917-30955967 (+)	87,034 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/10/2022 MGI 6.19