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Dpysl5 Gene Detail
Summary
  • Symbol
    Dpysl5
  • Name
    dihydropyrimidinase-like 5
  • Synonyms
    CRAM, Crmp5, CRMP-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929772
    NCBI Gene: 65254
  • Gene Overview
    MyGene.info: DPYSL5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:30711569-30799369 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 16.80 cM, cytoband B1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    635 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929772
protein coding gene Chr5:30711564-30799375 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029395
protein coding gene Chr5:28665390-28753915 (+)
A/J MGP_AJ_G0029361
protein coding gene Chr5:27729516-27818976 (+)
AKR/J MGP_AKRJ_G0029312
protein coding gene Chr5:28880648-28967701 (+)
BALB/cJ MGP_BALBcJ_G0029372
protein coding gene Chr5:28254808-28342103 (+)
C3H/HeJ MGP_C3HHeJ_G0029093
protein coding gene Chr5:28872947-28962294 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029825
protein coding gene Chr5:30440163-30532759 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027063
protein coding gene Chr5:25216062-25300589 (+)
CAST/EiJ MGP_CASTEiJ_G0028504
protein coding gene Chr5:27969862-28054892 (+)
CBA/J MGP_CBAJ_G0029061
protein coding gene Chr5:31007234-31103738 (+)
DBA/2J MGP_DBA2J_G0029210
protein coding gene Chr5:27916470-28003668 (+)
FVB/NJ MGP_FVBNJ_G0029168
protein coding gene Chr5:27328592-27416335 (+)
LP/J MGP_LPJ_G0029295
protein coding gene Chr5:29124675-29216854 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029197
protein coding gene Chr5:31908986-31995233 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029859
protein coding gene Chr5:28381310-28471283 (+)
PWK/PhJ MGP_PWKPhJ_G0028228
protein coding gene Chr5:27030383-27116444 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028059
protein coding gene Chr5:27729106-27817495 (+)
WSB/EiJ MGP_WSBEiJ_G0028584
protein coding gene Chr5:28451472-28536055 (+)



Homology
more
  • Human Ortholog
    DPYSL5, dihydropyrimidinase like 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DPYSL5, dihydropyrimidinase like 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRAM, CRMP5, CRMP-5, Ulip6
  • Links
    NCBI Gene ID: 56896
    neXtProt AC: NX_Q9BPU6
    UniProt: Q9BPU6

  • Chr Location
    2p23.3; chr2:26848101-26950351 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit limb grasping, abnormal Purkinje morphology, absent long term depression, and no response to BDNF.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 65254 NCBI Gene Model | MGI Sequence Detail 87801 C57BL/6J ±  kb
transcript NM_023047 RefSeq | MGI Sequence Detail 5408 C57BL/6  
polypeptide Q9EQF6 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 133
    Genomic 3
    cDNA 130

    Microarray probesets 4
References
more
  • Summaries
    All 52
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 5
    Phenotypes 26
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:215487 Thompson CL, et al., A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory