About   Help   FAQ
Klrc3 Gene Detail
Summary
  • Symbol
    Klrc3
  • Name
    killer cell lectin-like receptor subfamily C, member 3
  • Synonyms
    NKG2E
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929720
    NCBI Gene: 58179
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:129639064-129643337 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929720
protein coding gene Chr6:129636263-129643511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031355
protein coding gene Chr6:133310195-133314420 (-)
A/J MGP_AJ_G0031326
protein coding gene Chr6:128213982-128218219 (-)
AKR/J MGP_AKRJ_G0031254
protein coding gene Chr6:131713700-131717937 (-)
BALB/cJ MGP_BALBcJ_G0031333
protein coding gene Chr6:127861547-127865784 (-)
C3H/HeJ MGP_C3HHeJ_G0031057
protein coding gene Chr6:131909269-131913506 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031792
protein coding gene Chr6:136823002-136829777 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0030435
protein coding gene Chr6:132152294-132177956 (-)
CBA/J MGP_CBAJ_G0031017
protein coding gene Chr6:142203921-142208158 (-)
DBA/2J MGP_DBA2J_G0031174
protein coding gene Chr6:127166366-127170603 (-)
FVB/NJ MGP_FVBNJ_G0031124
protein coding gene Chr6:126055142-126059413 (-)
LP/J MGP_LPJ_G0031254
protein coding gene Chr6:133535515-133539752 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031162
protein coding gene Chr6:146083371-146087644 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031825
protein coding gene Chr6:131793436-131797691 (-)
PWK/PhJ MGP_PWKPhJ_G0030153
protein coding gene Chr6:125451752-125456079 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029982
protein coding gene Chr6:129802876-129805482 (-)
WSB/EiJ MGP_WSBEiJ_G0030523
protein coding gene Chr6:132212763-132216989 (-)



Homology
more
  • Human Ortholog
    KLRC3, killer cell lectin like receptor C3
  • Vertebrate Orthologs
    3
  • Human Ortholog
    KLRC3, killer cell lectin like receptor C3
    Orthology source: HGNC
  • Synonyms
    NKG2E, NKG2-E
  • Links
    NCBI Gene ID: 3823
    neXtProt AC: NX_Q07444
    UniProt: Q07444

  • Chr Location
    12p13.2; chr12:10412315-10420595 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033027 Ensembl Gene Model | MGI Sequence Detail 4274 C57BL/6J ±  kb
transcript ENSMUST00000071149 Ensembl | MGI Sequence Detail 715 Not Applicable  
polypeptide ENSMUSP00000071147 Ensembl | MGI Sequence Detail 221 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
Molecular
Reagents
less
  • All nucleic 1
    cDNA 1

    Microarray probesets 3
References
more
  • Summaries
    All 15
    Gene Ontology 1
    Phenotypes 3
  • Earliest
    J:66316 Vance RE, et al., Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. J Exp Med. 1999 Dec 20;190(12):1801-12
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2019
MGI 6.14
The Jackson Laboratory