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Plin4 Gene Detail
Summary
  • Symbol
    Plin4
  • Name
    perilipin 4
  • Synonyms
    S3-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929709
    NCBI Gene: 57435
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56407591-56416803 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 29.16 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    442 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929709
 protein coding gene Chr17:56407587-56416947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023912
 protein coding gene Chr17:57744544-57754446 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0023841
 protein coding gene Chr17:56861697-56870873 (-)
BALB/cJ MGP_BALBcJ_G0023873
 protein coding gene Chr17:56015219-56023243 (-)
C3H/HeJ MGP_C3HHeJ_G0023636
 protein coding gene Chr17:57569994-57582596 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024317
 protein coding gene Chr17:60032403-60039984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021764
 protein coding gene Chr17:52686543-52695443 (-)
CAST/EiJ MGP_CASTEiJ_G0023119
 protein coding gene Chr17:57886716-57893438 (-)
CBA/J MGP_CBAJ_G0023613
 protein coding gene Chr17:62324886-62338624 (-)
DBA/2J MGP_DBA2J_G0023741
 protein coding gene Chr17:54906993-54915213 (-)
FVB/NJ MGP_FVBNJ_G0023707
 protein coding gene Chr17:54427491-54435578 (-)
LP/J MGP_LPJ_G0023821
 protein coding gene Chr17:58452951-58461709 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023734
 protein coding gene Chr17:61882875-61892160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024362
 protein coding gene Chr17:57238191-57247403 (-)
PWK/PhJ MGP_PWKPhJ_G0022864
 protein coding gene Chr17:54251213-54261564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022676
 protein coding gene Chr17:54008510-54015441 (-)
WSB/EiJ MGP_WSBEiJ_G0023183
 protein coding gene Chr17:57854590-57861426 (-)



Homology
more
  • Human Ortholog
    PLIN4, perilipin 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLIN4, perilipin 4
  • Synonyms
    KIAA1881, MDRV, MRUPAV, NIPA2, S3-12
  • Links
    NCBI Gene ID: 729359
    UniProt: Q96Q06

  • Chr Location
    19p13.3; chr19:4502192-4518486 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased triglyceride in the heart and protection from cardiac steatosis induced by prolonged fasting, feeding or genetic obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    805
  • Tissues
    41
  • cDNA Data
    31
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002831 Ensembl Gene Model | MGI Sequence Detail 9213 C57BL/6J ±  kb
    transcript ENSMUST00000238734 Ensembl | MGI Sequence Detail 6350 Not Applicable  
    polypeptide ENSMUSP00000158677 Ensembl | MGI Sequence Detail 1601 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 31
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:66340 Scherer PE, et al., Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol. 1998 Jun;16(6):581-6
    • Latest
      J:357981 Pei J, et al., Senp7 deficiency impairs lipid droplets maturation in white adipose tissues via Plin4 deSUMOylation. J Biol Chem. 2024 Apr 25;300(6):107319
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory