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Plin4 Gene Detail
Summary
  • Symbol
    Plin4
  • Name
    perilipin 4
  • Synonyms
    S3-12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929709
    NCBI Gene: 57435
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56100591-56109803 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.16 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929709
protein coding gene Chr17:56100587-56109953 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023912
protein coding gene Chr17:57744544-57754446 (-)
A/J no annotation
AKR/J MGP_AKRJ_G0023841
protein coding gene Chr17:56861697-56870873 (-)
BALB/cJ MGP_BALBcJ_G0023873
protein coding gene Chr17:56015219-56023243 (-)
C3H/HeJ MGP_C3HHeJ_G0023636
protein coding gene Chr17:57569994-57582596 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024317
protein coding gene Chr17:60032403-60039984 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021764
protein coding gene Chr17:52686543-52695443 (-)
CAST/EiJ MGP_CASTEiJ_G0023119
protein coding gene Chr17:57886716-57893438 (-)
CBA/J MGP_CBAJ_G0023613
protein coding gene Chr17:62324886-62338624 (-)
DBA/2J MGP_DBA2J_G0023741
protein coding gene Chr17:54906993-54915213 (-)
FVB/NJ MGP_FVBNJ_G0023707
protein coding gene Chr17:54427491-54435578 (-)
LP/J MGP_LPJ_G0023821
protein coding gene Chr17:58452951-58461709 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023734
protein coding gene Chr17:61882875-61892160 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024362
protein coding gene Chr17:57238191-57247403 (-)
PWK/PhJ MGP_PWKPhJ_G0022864
protein coding gene Chr17:54251213-54261564 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022676
protein coding gene Chr17:54008510-54015441 (-)
WSB/EiJ MGP_WSBEiJ_G0023183
protein coding gene Chr17:57854590-57861426 (-)



Homology
more
  • Human Ortholog
    PLIN4, perilipin 4
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PLIN4, perilipin 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    KIAA1881, S3-12
  • Links
    NCBI Gene ID: 729359
    neXtProt AC: NX_Q96Q06
    UniProt: Q96Q06

  • Chr Location
    19p13.3; chr19:4502180-4520285 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased triglyceride in the heart and protection from cardiac steatosis induced by prolonged fasting, feeding or genetic obesity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002831 Ensembl Gene Model | MGI Sequence Detail 9213 C57BL/6J ±  kb
transcript ENSMUST00000002908 Ensembl | MGI Sequence Detail 5755 Not Applicable  
polypeptide ENSMUSP00000002908 Ensembl | MGI Sequence Detail 1403 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • InterPro Domains
    IPR004279 Perilipin
Molecular
Reagents
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  • All nucleic 31
    cDNA 31

    Microarray probesets 6
References
more
  • Summaries
    All 37
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:66340 Scherer PE, et al., Cloning of cell-specific secreted and surface proteins by subtractive antibody screening. Nat Biotechnol. 1998 Jun;16(6):581-6
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory