Xpo7 MGI Mouse Gene Detail - MGI:1929705

Symbol

Xpo7
Name

exportin 7
Synonyms

4930506C02Rik, Ranbp16

Feature Type

protein coding gene
IDs

MGI:1929705
NCBI Gene: 65246
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr14:70899566-71004075 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 36.44 cM, cytoband D1
Mapping Data

3 experiments

SNPs within 2kb

1924 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929705	protein coding gene	Chr14:70891686-71004075 (-)
129S1/SvImJ	ENSMUSG00200027459	protein coding gene	Chr14:59284992-59389862 (-)
A/J	ENSMUSG00195013947	protein coding gene	Chr14:59465008-59569797 (-)
AKR/J	ENSMUSG00220028868	protein coding gene	Chr14:58800488-58912999 (-)
BALB/cJ	ENSMUSG00180030412	protein coding gene	Chr14:59073580-59178356 (-)
C3H/HeJ	ENSMUSG00175036566	protein coding gene	Chr14:60834059-60938884 (-)
C57BL/6NJ	ENSMUSG00215022141	protein coding gene	Chr14:59010013-59122609 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019493	protein coding gene	Chr14:61762079-61865334 (-)
CAST/EiJ	ENSTCUG00005034905	protein coding gene	Chr14:60715075-60820363 (-)
CBA/J	ENSMUSG00210038430	protein coding gene	Chr14:59449617-59562194 (-)
DBA/2J	ENSMUSG00185022268	protein coding gene	Chr14:64619439-64724257 (-)
FVB/NJ	ENSMUSG00205034565	protein coding gene	Chr14:58959904-59062660 (-)
JF1/MsJ	ENSUMUG00000019242	protein coding gene	Chr14:75796072-75900898 (-)
LP/J	ENSMUSG00230013546	protein coding gene	Chr14:76648709-76753571 (-)
NOD/ShiLtJ	ENSMUSG00190029092	protein coding gene	Chr14:59244752-59357338 (-)
NZO/HlLtJ	ENSMUSG00225038945	protein coding gene	Chr14:66971553-67084129 (-)
PWK/PhJ	ENSLUMG00010032845	protein coding gene	Chr14:58646810-58751735 (-)
SPRET/EiJ	ENSMSPG00010023587	protein coding gene	Chr14:62209930-62309824 (-)
WSB/EiJ	ENSIUOG00005035963	protein coding gene	Chr14:58687708-58793484 (-)

Human Ortholog

XPO7, exportin 7

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XPO7, exportin 7
Synonyms

EXP7, RANBP16
Links

HGNC:14108

NCBI Gene ID: 23039

UniProt: Q9UIA9
Chr Location

8p21.3; chr8:21919641-22006585 (+) GRCh38

MGI Vertebrate Homology

Xpo7 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XPO7
Gene Tree

Xpo7

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Phenotype Summary

12 phenotypes from 4 alleles in 4 genetic backgrounds
1 phenotype from multigenic genotypes
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

45
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

31
Targeted

7
Genomic Mutations

1 involving Xpo7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit impaired stress erythropoiesis, mild anemia, and partial lethality during organogenesis.

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All GO Annotations

27
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

623
Tissues

7
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xpo7

ZFIN xpo7

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All Sequences

75
RefSeq

10
UniProt

3
CCDS

CCDS36974.1, CCDS88710.1

Ensembl

ENSMUSG00000022100 (Evidence)
NCBI Gene

65246

			Length	Strain/Species	Flank
genomic	65246	NCBI Gene Model \| MGI Sequence Detail	104510	C57BL/6J	± kb
transcript	NM_023045	RefSeq \| MGI Sequence Detail	7245	C57BL/6
polypeptide	Q9EPK7	UniProt \| EBI \| MGI Sequence Detail	1087	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017501 exportin-7

(term hierarchy)
InterPro Domains

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR044189 Exportin 4/7-like

IPR057947 Exportin-7/Ran-binding protein 17, TPR domain

IPR001494 Importin-beta, N-terminal domain
GlyGen

Q9EPK7 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 29

cDNA 26

Primer pair 3

Antibodies 1

Microarray probesets 8

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MGI:1922351, MGI:2145856

Summaries

All 48

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 13
Earliest

J:65836 Koch P, et al., Identification of a novel putative ran-binding protein and its close homologue. Biochem Biophys Res Commun. 2000 Nov 11;278(1):241-9
Latest

J:372316 Toyoda S, et al., Schizophrenia-related Xpo7 haploinsufficiency leads to behavioral and nuclear transport pathologies. EMBO Rep. 2025 Feb;26(4):948-981

TSS for Xpo7:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr129645	Chr14:71004038-71004084 (-)	14 bp
Tssr129644	Chr14:71003974-71004004 (-)	86 bp
Tssr129643	Chr14:70991995-70991996 (-)	12,079 bp
Tssr129642	Chr14:70945474-70945477 (-)	58,599 bp
Tssr129641	Chr14:70945457-70945470 (-)	58,611 bp
Tssr129640	Chr14:70945434-70945451 (-)	58,632 bp
Tssr4472	Chr14:70945418-70945426 (-)	58,653 bp
Tssr129639	Chr14:70914774-70914780 (-)	89,298 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29