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Sorcs1 Gene Detail
Summary
  • Symbol
    Sorcs1
  • Name
    sortilin-related VPS10 domain containing receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929666
    NCBI Gene: 58178
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:50143299-50678646 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 45.05 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4435 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929666
protein coding gene Chr19:50143295-50679136 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025240
protein coding gene Chr19:50141483-50690023 (-)
A/J MGP_AJ_G0025216
protein coding gene Chr19:47616640-48164439 (-)
AKR/J MGP_AKRJ_G0025185
protein coding gene Chr19:49167215-49718544 (-)
BALB/cJ MGP_BALBcJ_G0025211
protein coding gene Chr19:47690714-48220653 (-)
C3H/HeJ MGP_C3HHeJ_G0024971
protein coding gene Chr19:49315431-49871238 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025654
protein coding gene Chr19:51334287-51888483 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023066
protein coding gene Chr19:46717704-47240177 (-)
CAST/EiJ MGP_CASTEiJ_G0024435
protein coding gene Chr19:49201958-49757723 (-)
CBA/J MGP_CBAJ_G0024951
protein coding gene Chr19:53893914-54468526 (-)
DBA/2J MGP_DBA2J_G0025083
protein coding gene Chr19:47446592-47972770 (-)
FVB/NJ MGP_FVBNJ_G0025044
protein coding gene Chr19:47203148-47725597 (-)
LP/J MGP_LPJ_G0025169
protein coding gene Chr19:50000816-50548507 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025075
protein coding gene Chr19:53186253-53768912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025712
protein coding gene Chr19:49300589-49857894 (-)
PWK/PhJ MGP_PWKPhJ_G0024184
protein coding gene Chr19:47378418-47908059 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023987
protein coding gene Chr19:47982614-48552229 (-)
WSB/EiJ MGP_WSBEiJ_G0024506
protein coding gene Chr19:49433570-49984366 (-)



Homology
more
  • Human Ortholog
    SORCS1, sortilin related VPS10 domain containing receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SORCS1, sortilin related VPS10 domain containing receptor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    hSorCS
  • Links
    NCBI Gene ID: 114815
    neXtProt AC: NX_Q8WY21
    UniProt: Q8WY21

  • Chr Location
    10q25.1; chr10:106573663-107181138 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele have abnormal amyloid beta levels in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043531 Ensembl Gene Model | MGI Sequence Detail 535348 C57BL/6J ±  kb
transcript ENSMUST00000209413 Ensembl | MGI Sequence Detail 4398 Not Applicable  
polypeptide ENSMUSP00000147463 Ensembl | MGI Sequence Detail 1192 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 37
    cDNA 33
    Primer pair 4

    Microarray probesets 4
References
more
  • Summaries
    All 32
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:66294 Hermey G, et al., Identification and characterization of SorCS, a third member of a novel receptor family. Biochem Biophys Res Commun. 1999 Dec 20;266(2):347-51
  • Latest
    J:261011 Subkhangulova A, et al., SORCS1 and SORCS3 control energy balance and orexigenic peptide production. EMBO Rep. 2018 Apr;19(4)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory