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Sorcs1 Gene Detail
Summary
  • Symbol
    Sorcs1
  • Name
    sortilin-related VPS10 domain containing receptor 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929666
    NCBI Gene: 58178
Location & Maps
more
  • Sequence Map
    Chr19:50143301-50678646 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      535346 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 45.05 cM, cytoband D2
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SORCS1, sortilin related VPS10 domain containing receptor 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SORCS1, sortilin related VPS10 domain containing receptor 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hSorCS
  • Links
    NCBI Gene ID: 114815
    neXtProt AC: NX_Q8WY21

  • Chr Location
    10q23-q25; chr10:106573663-107181126 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Female mice homozygous for a null allele have abnormal amyloid beta levels in the brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000043531 Ensembl Gene Model | MGI Sequence Detail 535346 C57BL/6J ±  kb
transcript ENSMUST00000072685 Ensembl | MGI Sequence Detail 4396 Not Applicable  
polypeptide ENSMUSP00000072472 Ensembl | MGI Sequence Detail 1192 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    4435 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 35
    cDNA 31
    Primer pair 4

    Microarray probesets 4
References
more
  • Summaries
    All 30
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 5
  • Earliest
    J:66294 Hermey G, et al., Identification and characterization of SorCS, a third member of a novel receptor family. Biochem Biophys Res Commun. 1999 Dec 20;266(2):347-51
  • Latest
    J:227672 Savas JN, et al., The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 2015 Aug 19;87(4):764-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory