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Tbk1
Gene Detail
 Symbol
Name
ID
Tbk1
TANK-binding kinase 1
MGI:1929658
Synonyms 1200008B05Rik
Feature Type protein coding gene
Genetic Map
Chromosome 10
69.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:121546455-121586794 bp, - strand
From NCBI annotation of GRCm38

  40340 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22742  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: inhibitor of nuclear factor kappa-B kinase subunit epsilon
Gene Tree: Tbk1

Human
homologs
Human Homolog TBK1, TANK-binding kinase 1
NCBI Gene ID 29110
neXtProt AC  NX_Q9UHD2
Human Synonyms  NAK, T2K
Human Chr (Location)  12q14.1; chr12:64452060-64502119 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Chemically induced (ENU)(1) Gene trapped(18) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality. Mice homozygous for a different knock-out allele exhibit increased prenatal lethality, increased infiltration of mononuclear and/or granulomatous cells in multiple organs and tissues at 3 months of age, and increased lethality in response to LPS.
 
Interactions
Tbk1 interacts with 198 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process activation of innate immune response, defense response to Gram-positive bacterium, ...
Component cytoplasm
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (118)    Tissues (109)    Images (21)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 118
cDNA source data(94)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000020115 (Evidence)
Entrez Gene56480 (Evidence)
UniGene34580
DFCITC1574663
DoTSDT.493314, DT.94276235
EC2.7.11.1
PDB4JLC, 4JL9
Consensus CDS ProjectCCDS24212.1
International Mouse Knockout Project StatusTbk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 56480 NCBI Gene Model | MGI Sequence Detail 40340 C57BL/6J ±  kb
transcript NM_019786 RefSeq | MGI Sequence Detail 3031 C57BL/6 
polypeptide Q9WUN2 UniProt | EBI | MGI Sequence Detail 729 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(460 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000001779 serine/threonine-protein kinase tbk1
Graphical View of Protein Domain Structure
References (Earliest) J:66310 Pomerantz JL, et al., NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. EMBO J. 1999 Dec 1;18(23):6694-704
(Latest) J:205493 Ono C, et al., Innate immune response induced by baculovirus attenuates transgene expression in Mammalian cells. J Virol. 2014 Feb;88(4):2157-67
All references(81)
Other
accession IDs
MGI:1914699, MGI:2143617, MGI:2143800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory