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Pex3 Gene Detail
Summary
  • Symbol
    Pex3
  • Name
    peroxisomal biogenesis factor 3
  • Synonyms
    1700014F15Rik, 2810027F19Rik, 2900010N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929646
    NCBI Gene: 56535
  • Gene Overview
    MyGene.info: PEX3
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:13523842-13553142 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.89 cM, cytoband A
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    312 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929646
 protein coding gene Chr10:13523842-13553142 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017023
 protein coding gene Chr10:10938431-10973207 (-)
A/J MGP_AJ_G0017001
 protein coding gene Chr10:10527994-10557289 (-)
AKR/J MGP_AKRJ_G0016965
 protein coding gene Chr10:10772169-10805566 (-)
BALB/cJ MGP_BALBcJ_G0016959
 protein coding gene Chr10:10551219-10580749 (-)
C3H/HeJ MGP_C3HHeJ_G0016784
 protein coding gene Chr10:10925273-10958992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017421
 protein coding gene Chr10:11229704-11260568 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015126
 protein coding gene Chr10:9802815-9832115 (-)
CAST/EiJ MGP_CASTEiJ_G0016366
 protein coding gene Chr10:10800373-10836981 (-)
CBA/J MGP_CBAJ_G0016756
 protein coding gene Chr10:11664412-11693534 (-)
DBA/2J MGP_DBA2J_G0016864
 protein coding gene Chr10:10438782-10468115 (-)
FVB/NJ MGP_FVBNJ_G0016859
 protein coding gene Chr10:10268999-10298193 (-)
LP/J MGP_LPJ_G0016939
 protein coding gene Chr10:10793628-10828359 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016889
 protein coding gene Chr10:11542952-11579756 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017459
 protein coding gene Chr10:10658969-10688320 (-)
PWK/PhJ MGP_PWKPhJ_G0016151
 protein coding gene Chr10:10319546-10350415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015934
 protein coding gene Chr10:10807173-10838386 (-)
WSB/EiJ MGP_WSBEiJ_G0016428
 protein coding gene Chr10:10699403-10731229 (-)



Homology
more
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PBD10A, PBD10B, TRG18
  • Links
    NCBI Gene ID: 8504
    neXtProt AC: NX_P56589
    UniProt: P56589

  • Chr Location
    6q24.2; chr6:143450781-143490616 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2691
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PEX3
  • Gene Tree
    Pex3
Human Diseases
more
  • Diseases
    1 with human PEX3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit abnormal sebaceous gland, hair follicle bulge, and cornea morphology. An increase in B and T cell numbers and mean platelet volume, and vertebral transformation are also seen.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    634
  • Tissues
    3
  • cDNA Data
    54
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56535 NCBI Gene Model | MGI Sequence Detail 29301 C57BL/6J ±  kb
    transcript NM_019961 RefSeq | MGI Sequence Detail 2303 C57BL/6  
    polypeptide Q9QXY9 UniProt | EBI | MGI Sequence Detail 372 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 1
      cDNA 55

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1914452, MGI:1914509, MGI:1922773
    References
    more
    • Summaries
      All 31
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:66341 Muntau AC, et al., Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Biol Chem. 2000 Apr;381(4):337-42
    • Latest
      J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    01/12/2021
    MGI 6.16     		The Jackson Laboratory