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Pex3 Gene Detail
Summary
  • Symbol
    Pex3
  • Name
    peroxisomal biogenesis factor 3
  • Synonyms
    1700014F15Rik, 2810027F19Rik, 2900010N04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929646
    NCBI Gene: 56535
  • Gene Overview
    MyGene.info: PEX3
Location & Maps
more
  • Sequence Map
    Chr10:13523847-13553139 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      29293 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 4.89 cM, cytoband A
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PEX3, peroxisomal biogenesis factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PBD10A, TRG18
  • Links
    NCBI Gene ID: 8504
    neXtProt AC: NX_P56589

  • Chr Location
    6q24.2; chr6:143450781-143490616 (+)  GRCh38.p2
  • HomoloGene
    Vertebrate Homology Class 2691
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: PEX3
  • Gene Tree
    Pex3
Human Diseases
more
  • Diseases
    1 with human PEX3 associations

Human Disease Mouse Models
       Peroxisome Biogenesis Disorder 10a (zellweger); PBD10A   OMIM: 614882
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    3
  • Gene trapped
    1
  • Targeted
    2
  • Incidental Mutations
    Mutagenetix , APF
Homozygous mutants exhibit abnormal sebaceous gland, hair follicle bulge, and cornea morphology. An increase in B and T cell numbers and mean platelet volume, and vertebral transformation are also seen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    3
  • Tissues
    3
  • cDNA Data
    52
  • Literature Summary
    1
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020905 VEGA Gene Model | MGI Sequence Detail 29293 C57BL/6J ±  kb
transcript OTTMUST00000049414 VEGA | MGI Sequence Detail 2129 Not Applicable  
polypeptide OTTMUSP00000022888 VEGA | MGI Sequence Detail 372 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    312 from dbSNP Build 142
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012564 peroxisomal biogenesis factor 3
  • InterPro Domains
    IPR006966 Peroxin-3
Molecular
Reagents
less
  • All nucleic 54
    Genomic 1
    cDNA 53

    Microarray probesets 4
Other
Accession IDs
less
MGI:1914452, MGI:1914509, MGI:1922773
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:66341 Muntau AC, et al., Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Biol Chem. 2000 Apr;381(4):337-42
  • Latest
    J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory