Pex3 MGI Mouse Gene Detail - MGI:1929646 - peroxisomal biogenesis factor 3

Symbol

Pex3
Name

peroxisomal biogenesis factor 3
Synonyms

1700014F15Rik, 2810027F19Rik, 2900010N04Rik

Feature Type

protein coding gene
IDs

MGI:1929646
NCBI Gene: 56535
Gene Overview

MyGene.info: PEX3
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr10:13523842-13553142 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 4.89 cM, cytoband A
Mapping Data

2 experiments

SNPs within 2kb

312 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929646	protein coding gene	Chr10:13523842-13553150 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017023	protein coding gene	Chr10:10938431-10973207 (-)
A/J	MGP_AJ_G0017001	protein coding gene	Chr10:10527994-10557289 (-)
AKR/J	MGP_AKRJ_G0016965	protein coding gene	Chr10:10772169-10805566 (-)
BALB/cJ	MGP_BALBcJ_G0016959	protein coding gene	Chr10:10551219-10580749 (-)
C3H/HeJ	MGP_C3HHeJ_G0016784	protein coding gene	Chr10:10925273-10958992 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0017421	protein coding gene	Chr10:11229704-11260568 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015126	protein coding gene	Chr10:9802815-9832115 (-)
CAST/EiJ	MGP_CASTEiJ_G0016366	protein coding gene	Chr10:10800373-10836981 (-)
CBA/J	MGP_CBAJ_G0016756	protein coding gene	Chr10:11664412-11693534 (-)
DBA/2J	MGP_DBA2J_G0016864	protein coding gene	Chr10:10438782-10468115 (-)
FVB/NJ	MGP_FVBNJ_G0016859	protein coding gene	Chr10:10268999-10298193 (-)
LP/J	MGP_LPJ_G0016939	protein coding gene	Chr10:10793628-10828359 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016889	protein coding gene	Chr10:11542952-11579756 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017459	protein coding gene	Chr10:10658969-10688320 (-)
PWK/PhJ	MGP_PWKPhJ_G0016151	protein coding gene	Chr10:10319546-10350415 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015934	protein coding gene	Chr10:10807173-10838386 (-)
WSB/EiJ	MGP_WSBEiJ_G0016428	protein coding gene	Chr10:10699403-10731229 (-)

Human Ortholog

PEX3, peroxisomal biogenesis factor 3

Vertebrate Orthologs

10

Human Ortholog

PEX3, peroxisomal biogenesis factor 3
Orthology source: HomoloGene, HGNC
Synonyms

PBD10A, PBD10B, TRG18
Links

HGNC:8858

NCBI Gene ID: 8504

neXtProt AC: NX_P56589

UniProt: P56589
Chr Location

6q24.2; chr6:143450781-143490616 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2691
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PEX3
Gene Tree

Pex3

Diseases

1 with human PEX3 associations

				Human Disease	Mouse Models
				peroxisome biogenesis disorder 10A IDs peroxisome biogenesis disorder 10A DOID:0080484 OMIM:614882

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

23 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit abnormal sebaceous gland, hair follicle bulge, and cornea morphology. An increase in B and T cell numbers and mean platelet volume, and vertebral transformation are also seen.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

3
Tissues

3
cDNA Data

54
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase pex3

ZFIN pex3

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Pex3 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

58
RefSeq

6
UniProt

6
CCDS

CCDS23702.1, CCDS48503.1, CCDS83681.1
UniGene

282711

Ensembl

ENSMUSG00000019809 (Evidence)
NCBI Gene

56535

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019809	Ensembl Gene Model \| MGI Sequence Detail	29301	C57BL/6J	± kb
transcript	ENSMUST00000019945	Ensembl \| MGI Sequence Detail	2129	Not Applicable
polypeptide	ENSMUSP00000019945	Ensembl \| MGI Sequence Detail	372	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012564 peroxisomal biogenesis factor 3

(term hierarchy)
InterPro Domains

IPR006966 Peroxin-3

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All nucleic 56

Genomic 1

cDNA 55

Microarray probesets 4

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MGI:1914452, MGI:1914509, MGI:1922773

Summaries

All 32

Developmental Gene Expression 1

Gene Ontology 6

Phenotypes 7
Earliest

J:66341 Muntau AC, et al., Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Biol Chem. 2000 Apr;381(4):337-42
Latest

J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

TSS for Pex3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96776	Chr10:13553155-13553166 (-)	-19 bp
Tssr96775	Chr10:13553140-13553153 (-)	-5 bp
Tssr96774	Chr10:13553111-13553126 (-)	23 bp
Tssr96773	Chr10:13553063-13553085 (-)	68 bp
Tssr96772	Chr10:13552999-13553061 (-)	112 bp
Tssr96771	Chr10:13552855-13552870 (-)	279 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14