Pex3 MGI Mouse Gene Detail - MGI:1929646 - peroxisomal biogenesis factor 3

Pex3 Gene Detail

Symbol

Pex3
Name

peroxisomal biogenesis factor 3
Synonyms

1700014F15Rik, 2810027F19Rik, 2900010N04Rik

Feature Type

protein coding gene
IDs

MGI:1929646
NCBI Gene: 56535
Gene Overview

MyGene.info: PEX3

Sequence Map

Chr10:13523847-13553139 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

29293 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 4.89 cM, cytoband A
Mapping Data

2 experiments

Human Ortholog

PEX3, peroxisomal biogenesis factor 3

Vertebrate Orthologs

10

Human Ortholog

PEX3, peroxisomal biogenesis factor 3
Orthology source: HomoloGene, HGNC
Synonyms

PBD10A, PBD10B, TRG18
Links

HGNC:8858

NCBI Gene ID: 8504

neXtProt AC: NX_P56589

UniProt: P56589
Chr Location

6q24.2; chr6:143450781-143490616 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2691
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: PEX3
Gene Tree

Pex3

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Phenotype Summary

22 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Gene trapped

1
Targeted

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

10 strains or lines available

Homozygous mutants exhibit abnormal sebaceous gland, hair follicle bulge, and cornea morphology. An increase in B and T cell numbers and mean platelet volume, and vertebral transformation are also seen.

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All GO Annotations

19
GO References

5

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

3
Tissues

3
cDNA Data

52
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN pex3

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Pex3 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

50
RefSeq

6
UniProt

6
CCDS

CCDS23702.1, CCDS48503.1, CCDS83681.1
UniGene

282711

			Length	Strain/Species	Flank
genomic	OTTMUSG00000020905	VEGA Gene Model \| MGI Sequence Detail	29293	C57BL/6J	± kb
transcript	OTTMUST00000049414	VEGA \| MGI Sequence Detail	2129	Not Applicable
polypeptide	OTTMUSP00000022888	VEGA \| MGI Sequence Detail	372	Not Applicable

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SNPs within 2kb

312 from dbSNP Build 142

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UniProt

6 Sequences
Protein Ontology

PR:000012564 peroxisomal biogenesis factor 3

(term hierarchy)
InterPro Domains

IPR006966 Peroxin-3

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All nucleic 54

Genomic 1

cDNA 53

Microarray probesets 4

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MGI:1914452, MGI:1914509, MGI:1922773

Summaries

All 30

Developmental Gene Expression 1

Gene Ontology 5

Phenotypes 6
Earliest

J:66341 Muntau AC, et al., Genomic organization, expression analysis, and chromosomal localization of the mouse PEX3 gene encoding a peroxisomal assembly protein. Biol Chem. 2000 Apr;381(4):337-42
Latest

J:209956 Liakath-Ali K, et al., Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nat Commun. 2014;5:3540

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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