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Stard3 Gene Detail
Summary
  • Symbol
    Stard3
  • Name
    START domain containing 3
  • Synonyms
    es64, Mln64
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929618
    NCBI Gene: 59045
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98358368-98381112 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929618
protein coding gene Chr11:98358367-98381112 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019055
protein coding gene Chr11:100896486-100920519 (+)
A/J MGP_AJ_G0019023
protein coding gene Chr11:96705049-96728105 (+)
AKR/J MGP_AKRJ_G0018993
protein coding gene Chr11:99696055-99722636 (+)
BALB/cJ MGP_BALBcJ_G0018996
protein coding gene Chr11:97195533-97219778 (+)
C3H/HeJ MGP_C3HHeJ_G0018810
protein coding gene Chr11:99832355-99856419 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019449
protein coding gene Chr11:103969866-104000441 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017080
protein coding gene Chr11:94144476-94167562 (+)
CAST/EiJ MGP_CASTEiJ_G0018364
protein coding gene Chr11:100707453-100729755 (+)
CBA/J MGP_CBAJ_G0018781
protein coding gene Chr11:108288377-108310864 (+)
DBA/2J MGP_DBA2J_G0018889
protein coding gene Chr11:96246603-96269516 (+)
FVB/NJ MGP_FVBNJ_G0018878
protein coding gene Chr11:95755061-95777711 (+)
LP/J MGP_LPJ_G0018959
protein coding gene Chr11:101375333-101399453 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018905
protein coding gene Chr11:108088888-108112691 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019489
protein coding gene Chr11:100028282-100050810 (+)
PWK/PhJ MGP_PWKPhJ_G0018136
protein coding gene Chr11:97253795-97276635 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017926
protein coding gene Chr11:99733593-99755919 (+)
WSB/EiJ MGP_WSBEiJ_G0018414
protein coding gene Chr11:99938559-99961086 (+)



Homology
more
  • Human Ortholog
    STARD3, StAR related lipid transfer domain containing 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STARD3, StAR related lipid transfer domain containing 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAB1, es64, MLN64
  • Links
    NCBI Gene ID: 10948
    neXtProt AC: NX_Q14849
    UniProt: Q14849

  • Chr Location
    17q12; chr17:39637080-39664201 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 38227
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STARD3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a truncated allele are viable and fertile and display mild defects in cholesterol metabolism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018167 Ensembl Gene Model | MGI Sequence Detail 22745 C57BL/6J ±  kb
    transcript ENSMUST00000018311 Ensembl | MGI Sequence Detail 2070 Not Applicable  
    polypeptide ENSMUSP00000018311 Ensembl | MGI Sequence Detail 446 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR019498 MENTAL domain
      IPR029867 StAR-related lipid transfer protein 3, C-terminal
      IPR002913 START domain
      IPR023393 START-like domain superfamily
      IPR000799 Steroidogenic acute regulatory protein-like
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 3
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 13
    • Earliest
      J:51120 Tomasetto C, et al., Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics. 1995 Aug 10;28(3):367-76
    • Latest
      J:192731 Ha SD, et al., Cellular adaptation to anthrax lethal toxin-induced mitochondrial cholesterol enrichment, hyperpolarization, and reactive oxygen species generation through downregulating MLN64 in macrophages. Mol Cell Biol. 2012 Dec;32(23):4846-60

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory