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Aatf Gene Detail
Summary
  • Symbol
    Aatf
  • Name
    apoptosis antagonizing transcription factor
  • Synonyms
    4933415H02Rik, 5830465M17Rik, Che-1, MGC:35916, Trb
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929608
    NCBI Gene: 56321
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:84422855-84513522 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      90668 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 51.30 cM, cytoband B5
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AATF, apoptosis antagonizing transcription factor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BFR2, CHE1, CHE-1, DED
  • Links
    NCBI Gene ID: 26574
    neXtProt AC: NX_Q9NY61
    UniProt: Q9NY61

  • Chr Location
    17q12; chr17:36948875-37056871 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 40811
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AATF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous embryos do not develop past the compacted morula stage, and after failing to maintain compaction. Mutant embryos show abnormal morphology at E3.5, with most not forming a blastocoel cavity. Severely reduced cell proliferation is observed before blastocyst formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000000987 VEGA Gene Model | MGI Sequence Detail 90668 C57BL/6J ±  kb
    transcript OTTMUST00000001937 VEGA | MGI Sequence Detail 1822 Not Applicable  
    polypeptide OTTMUSP00000000935 VEGA | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      659 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 1
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918392, MGI:1923349
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 9
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261042 Welcker D, et al., AATF suppresses apoptosis, promotes proliferation and is critical for Kras-driven lung cancer. Oncogene. 2018 Mar;37(11):1503-1518

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory