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Ndfip1
Gene Detail
 Symbol
Name
ID
Ndfip1
Nedd4 family interacting protein 1
MGI:1929601
Synonyms 0610010M22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
20.32 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:38418975-38464399 bp, + strand
From Ensembl annotation of GRCm38

  45425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Gene Tree: Ndfip1

Human
homologs
Human Homolog NDFIP1, Nedd4 family interacting protein 1
NCBI Gene ID 80762
neXtProt AC  NX_Q9BT67
Human Synonyms  N4WBP5
Human Chr (Location)  5q31.3; chr5:142108759-142154443 (+)  GRCh38
Alleles
and
phenotypes
All alleles(29) : Targeted(4) Gene trapped(25)
 
Mice homozygous for a gene-trapped allele exhibit hepatomegaly, splenomegaly, extramedullary hematopoiesis and shorter tails, develop severe inflammation of the skin and lung due to T-cell hyperactivation and abnormal T-helper 2 physiology, and die prematurely.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular iron ion homeostasis, negative regulation of gene expression, ...
Component cell cortex, endosome, ...
Function protein binding, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (153)    Tissues (30)    Images (40)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 153
cDNA source data(289)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(293) cDNA(292) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024425 (Evidence)
Entrez Gene65113 (Evidence)
UniGene102496
DFCITC1574221, TC1598448, TC1658124, TC1743256
DoTSDT.101370366, DT.110761570, DT.495926, DT.97365504
NIA Mouse Gene IndexU018642
Consensus CDS ProjectCCDS37789.1
International Mouse Knockout Project StatusNdfip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024425 Ensembl Gene Model | MGI Sequence Detail 45425 C57BL/6J ±  kb
transcript ENSMUST00000025293 Ensembl | MGI Sequence Detail 930 Not Applicable 
polypeptide ENSMUSP00000025293 Ensembl | MGI Sequence Detail 221 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(5) UniProt(1)
Polymorphisms SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019325 NEDD4/BSD2
Protein Ontology PR:000011053 NEDD4 family-interacting protein 1
References (Earliest) J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
(Latest) J:205692 Ramos-Hernandez N, et al., Ndfip1 enforces a requirement for CD28 costimulation by limiting IL-2 production. J Immunol. 2013 Aug 15;191(4):1536-46
All references(48)
Other
accession IDs
MGI:1918924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory