Ndfip1
Gene Detail

Symbol Name ID

Ndfip1 Nedd4 family interacting protein 1 MGI:1929601

Synonyms

0610010M22Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

20.32 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:38418975-38464399 bp, + strand From Ensembl annotation of GRCm38   45425 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 zebrafish

Gene Tree: Ndfip1

Human homologs

Human Homolog		NDFIP1, Nedd4 family interacting protein 1
NCBI Gene ID		80762
neXtProt AC		NX_Q9BT67
Human Synonyms		N4WBP5
Human Chr (Location)		5q31.3; chr5:141488324-141534008 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(28) : Targeted(3) Gene trapped(25)
 

Mice homozygous for a gene-trapped allele exhibit hepatomegaly, splenomegaly, extramedullary hematopoiesis and shorter tails, develop severe inflammation of the skin and lung due to T-cell hyperactivation and abnormal T-helper 2 physiology, and die prematurely.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	cellular iron ion homeostasis, negative regulation of gene expression, ...
Component	cell cortex, endosome, ...
Function	protein binding, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (153)    Tissues (30)    Images (40)
Theiler Stages: 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	153

cDNA source data(261)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(265) cDNA(264) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024425 (Evidence)
Entrez Gene	65113 (Evidence)
UniGene	102496
DFCI	TC1574221, TC1598448, TC1658124, TC1743256
DoTS	DT.101370366, DT.110761570, DT.495926, DT.97365504
NIA Mouse Gene Index	U018642
Consensus CDS Project	CCDS37789.1
International Mouse Knockout Project Status	Ndfip1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000024425	Ensembl Gene Model | MGI Sequence Detail	45425	C57BL/6J
transcript	ENSMUST00000025293	Ensembl | MGI Sequence Detail	930	Not Applicable
polypeptide	ENSMUSP00000025293	Ensembl | MGI Sequence Detail	221	Not Applicable

All sequences(30) RefSeq(3) UniProt(1)

Polymorphisms

SNPs(239 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019325	NEDD4/BSD2
Protein Ontology	PR:000011053	NEDD4 family-interacting protein 1

References

(Earliest) J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
(Latest) J:188722 Altin JA, et al., IL-10+ CTLA-4+ Th2 inhibitory cells form in a Foxp3-independent, IL-2-dependent manner from Th2 effectors during chronic inflammation. J Immunol. 2012 Jun 1;188(11):5478-88
All references(46)

Other accession IDs

MGI:1918924