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Ndfip1 Gene Detail
Summary
  • Symbol
    Ndfip1
  • Name
    Nedd4 family interacting protein 1
  • Synonyms
    0610010M22Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929601
    NCBI Gene: 65113
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:38418975-38464399 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      45425 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 20.32 cM, cytoband B3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDFIP1, Nedd4 family interacting protein 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NDFIP1, Nedd4 family interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    N4WBP5
  • Links
    NCBI Gene ID: 80762
    neXtProt AC: NX_Q9BT67
    UniProt: Q9BT67

  • Chr Location
    5q31.3; chr5:142108759-142154443 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 5 alleles in 6 genetic backgrounds
    14 phenotypes from multigenic genotypes
    2 images
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele develop severe inflammation of the skin and lung due to T-cell hyperactivation and abnormal T-helper 2 physiology, and die prematurely. Mice homozygous for a null allele exhibit hypersensitivity of dopaminergic neurons to iron toxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024425 Ensembl Gene Model | MGI Sequence Detail 45425 C57BL/6J ±  kb
    transcript ENSMUST00000025293 Ensembl | MGI Sequence Detail 930 Not Applicable  
    polypeptide ENSMUSP00000025293 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      251 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 293
      cDNA 292
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1918924
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 7
      Gene Ontology 7
      Phenotypes 24
    • Earliest
      J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
    • Latest
      J:243853 Layman AAK, et al., Ndfip1 restricts Th17 cell potency by limiting lineage stability and proinflammatory cytokine production. Sci Rep. 2017 Jan 04;7(None):39649

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory