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Ndfip1
Gene Detail
Symbol

Name
ID
Ndfip1
Nedd4 family interacting protein 1
MGI:1929601
Synonyms
0610010M22Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 18
20.32 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:38418975-38464399 bp, + strand
From Ensembl annotation of GRCm38

  45425 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12730  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NDFIP1
Gene Tree: Ndfip1

Human
homologs
NDFIP1, Nedd4 family interacting protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 80762
neXtProt AC: NX_Q9BT67

Human Synonyms: N4WBP5

Human Chr (Location): 5q31.3; chr5:142108759-142154443 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Chemically induced (ENU)(1) Gene trapped(25) Targeted(5)
 
Mice homozygous for a gene-trapped allele exhibit hepatomegaly, splenomegaly, extramedullary hematopoiesis and shorter tails, develop severe inflammation of the skin and lung due to T-cell hyperactivation and abnormal T-helper 2 physiology, and die prematurely.
 
Phenotype Images(2)
Interactions
Ndfip1 interacts with 50 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process cellular iron ion homeostasis, negative regulation of gene expression, ...
Component cell cortex, endosome, ...
Function protein binding, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (153)    Tissues (31)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 153
cDNA source data(289)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ndfip1 ; ZFIN ndfip1    NEW 
Molecular
reagents
All nucleic(293) cDNA(292) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000024425 (Evidence)
Entrez Gene 65113 (Evidence)
UniGene 102496
DFCI TC1574221, TC1598448, TC1658124, TC1743256
DoTS DT.101370366, DT.110761570, DT.495926, DT.97365504
NIA Mouse Gene Index U018642
Consensus CDS Project CCDS37789.1
International Mouse Phenotyping Consortium Status Ndfip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024425 Ensembl Gene Model | MGI Sequence Detail 45425 C57BL/6J ±  kb
transcript ENSMUST00000025293 Ensembl | MGI Sequence Detail 930 Not Applicable 
polypeptide ENSMUSP00000025293 Ensembl | MGI Sequence Detail 221 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(5) UniProt(1)
Polymorphisms
SNPs within 2kb(251 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019325 NEDD4/Bsd2
Protein Ontology PR:000011053 NEDD4 family-interacting protein 1
References
(Earliest) J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
(Latest) J:212711 Howitt J, et al., Increased Ndfip1 in the substantia nigra of parkinsonian brains is associated with elevated iron levels. PLoS One. 2014;9(1):e87119
All references(49)
Other
accession IDs
MGI:1918924

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory