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Prrg2 Gene Detail
Summary
  • Symbol
    Prrg2
  • Name
    proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
  • Synonyms
    1600014G02Rik, 2510041M06Rik, N4WBP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929596
    NCBI Gene: 65116
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45053584-45062677 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.10 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    49 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929596
protein coding gene Chr7:45053584-45062882 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032196
protein coding gene Chr7:45280719-45288752 (-)
A/J MGP_AJ_G0032175
protein coding gene Chr7:44424477-44432510 (-)
AKR/J MGP_AKRJ_G0032111
protein coding gene Chr7:45652906-45660939 (-)
BALB/cJ MGP_BALBcJ_G0032187
protein coding gene Chr7:44423960-44431993 (-)
C3H/HeJ MGP_C3HHeJ_G0031903
protein coding gene Chr7:46150816-46158903 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032679
protein coding gene Chr7:47556386-47565518 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029693
protein coding gene Chr7:46987872-46996097 (-)
CAST/EiJ MGP_CASTEiJ_G0031231
protein coding gene Chr7:37527660-37535702 (-)
CBA/J MGP_CBAJ_G0031867
protein coding gene Chr7:49110559-49118592 (-)
DBA/2J MGP_DBA2J_G0032025
protein coding gene Chr7:44094158-44102186 (-)
FVB/NJ MGP_FVBNJ_G0031976
protein coding gene Chr7:43872684-43880878 (-)
LP/J MGP_LPJ_G0032103
protein coding gene Chr7:45960072-45970472 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032013
protein coding gene Chr7:47827031-47835072 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032695
protein coding gene Chr7:44869151-44877202 (-)
PWK/PhJ MGP_PWKPhJ_G0030954
protein coding gene Chr7:37458361-37466822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030791
protein coding gene Chr7:32876159-32885336 (-)
WSB/EiJ MGP_WSBEiJ_G0031348
protein coding gene Chr7:45351503-45360994 (-)



Homology
more
  • Human Ortholog
    PRRG2, proline rich and Gla domain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PRRG2, proline rich and Gla domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRGP2
  • Links
    NCBI Gene ID: 5639
    neXtProt AC: NX_O14669
    UniProt: O14669

  • Chr Location
    19q13.33; chr19:49580617-49591008 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000007837 Ensembl Gene Model | MGI Sequence Detail 9094 C57BL/6J ±  kb
transcript ENSMUST00000210690 Ensembl | MGI Sequence Detail 1623 Not Applicable  
polypeptide ENSMUSP00000148014 Ensembl | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000013313 transmembrane gamma-carboxyglutamic acid protein 2
  • InterPro Domains
    IPR017857 Coagulation factor-like, Gla domain superfamily
    IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
    IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
Molecular
Reagents
less
  • All nucleic 55
    cDNA 55

    Microarray probesets 4
Other
Accession IDs
less
MGI:1917009, MGI:1917289
References
more
  • Summaries
    All 32
    Developmental Gene Expression 1
    Gene Ontology 4
    Phenotypes 9
  • Earliest
    J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
10/01/2019
MGI 6.14
The Jackson Laboratory