About   Help   FAQ
Prrg2 Gene Detail
Summary
  • Symbol
    Prrg2
  • Name
    proline-rich Gla (G-carboxyglutamic acid) polypeptide 2
  • Synonyms
    1600014G02Rik, 2510041M06Rik, N4WBP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929596
    NCBI Gene: 65116
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44703008-44711828 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.10 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    247 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929596
 protein coding gene Chr7:44703008-44712101 (-)
129S1/SvImJ ENSMUSG00200023399
 protein coding gene Chr7:32299732-32308822 (-)
A/J ENSMUSG00195042445
 protein coding gene Chr7:36327808-36336897 (-)
AKR/J ENSMUSG00220007578
 protein coding gene Chr7:30632763-30641852 (-)
BALB/cJ ENSMUSG00180038365
 protein coding gene Chr7:33203213-33212301 (-)
C3H/HeJ ENSMUSG00175033237
 protein coding gene Chr7:33735662-33744750 (-)
C57BL/6NJ ENSMUSG00215044491
 protein coding gene Chr7:32995792-33004889 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029693
 protein coding gene Chr7:46987872-46996097 (-)
CAST/EiJ ENSTCUG00005042202
 protein coding gene Chr7:36711405-36720474 (-)
CBA/J ENSMUSG00210036474
 protein coding gene Chr7:34107021-34116110 (-)
DBA/2J ENSMUSG00185040847
 protein coding gene Chr7:37979645-37988733 (-)
FVB/NJ ENSMUSG00205036118
 protein coding gene Chr7:33651331-33660423 (-)
JF1/MsJ ENSUMUG00000026569
 protein coding gene Chr7:42466526-42475635 (-)
LP/J ENSMUSG00230047202
 protein coding gene Chr7:43408233-43417348 (-)
NOD/ShiLtJ ENSMUSG00190033299
 protein coding gene Chr7:33979070-33988164 (-)
NZO/HlLtJ ENSMUSG00225015675
 protein coding gene Chr7:41616664-41625758 (-)
PWK/PhJ ENSLUMG00010044796
 protein coding gene Chr7:32935188-32944304 (-)
SPRET/EiJ ENSMSPG00010042654
 protein coding gene Chr7:32711806-32720900 (-)
WSB/EiJ ENSIUOG00005027310
 protein coding gene Chr7:34523497-34532619 (-)



Homology
more
  • Human Ortholog
    PRRG2, proline rich and Gla domain 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRRG2, proline rich and Gla domain 2
  • Synonyms
    PRGP2
  • Links
    NCBI Gene ID: 5639
    UniProt: O14669

  • Chr Location
    19q13.33; chr19:49580617-49591004 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    53
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65116 NCBI Gene Model | MGI Sequence Detail 8821 C57BL/6J ±  kb
    transcript NM_001419032 RefSeq | MGI Sequence Detail 1432 C57BL/6  
    polypeptide Q8R182 UniProt | EBI | MGI Sequence Detail 198 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000013313 transmembrane gamma-carboxyglutamic acid protein 2
      (term hierarchy)
    • InterPro Domains
      IPR017857 Coagulation factor-like, Gla domain superfamily
      IPR000294 Gamma-carboxyglutamic acid-rich (GLA) domain
      IPR035972 Gamma-carboxyglutamic acid-rich (GLA) domain superfamily
      IPR050442 Peptidase S1 family, coagulation factors
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 55

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1917009, MGI:1917289
    References
    more
    • Summaries
      All 37
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:65663 Jolliffe CN, et al., Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase nedd4. Biochem J. 2000 Nov 1;351 Pt 3:557-65
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory