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Slc16a8 Gene Detail
Summary
  • Symbol
    Slc16a8
  • Name
    solute carrier family 16 (monocarboxylic acid transporters), member 8
  • Synonyms
    Mct3, proton-coupled monocarboxylate transporter 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929519
    NCBI Gene: 57274
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79251016-79254748 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 37.70 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929519
protein coding gene Chr15:79251014-79254761 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022069
protein coding gene Chr15:79507711-79511458 (-)
A/J MGP_AJ_G0022030
protein coding gene Chr15:76767075-76770837 (-)
AKR/J MGP_AKRJ_G0022005
protein coding gene Chr15:78899507-78903260 (-)
BALB/cJ MGP_BALBcJ_G0022036
protein coding gene Chr15:76756269-76760028 (-)
C3H/HeJ MGP_C3HHeJ_G0021807
protein coding gene Chr15:78892753-78896510 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022479
protein coding gene Chr15:82627988-82631733 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020009
protein coding gene Chr15:73248906-73252671 (-)
CAST/EiJ MGP_CASTEiJ_G0021328
protein coding gene Chr15:79596867-79600598 (-)
CBA/J MGP_CBAJ_G0021772
protein coding gene Chr15:85185047-85188797 (-)
DBA/2J MGP_DBA2J_G0021901
protein coding gene Chr15:76245288-76249044 (-)
FVB/NJ MGP_FVBNJ_G0021879
protein coding gene Chr15:75277864-75282203 (-)
LP/J MGP_LPJ_G0021969
protein coding gene Chr15:79699659-79703405 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021899
protein coding gene Chr15:90332751-90336499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022493
protein coding gene Chr15:78915999-78919747 (-)
PWK/PhJ MGP_PWKPhJ_G0021070
protein coding gene Chr15:76256187-76259986 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020907
protein coding gene Chr15:78725581-78729337 (-)
WSB/EiJ MGP_WSBEiJ_G0021380
protein coding gene Chr15:79301226-79304976 (-)



Homology
more
  • Human Ortholog
    SLC16A8, solute carrier family 16 member 8
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SLC16A8, solute carrier family 16 member 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCT3, REMP
  • Links
    NCBI Gene ID: 23539
    neXtProt AC: NX_O95907
    UniProt: O95907

  • Chr Location
    22q13.1; chr22:38078137-38083163 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit reduced visual function, putatively due to changes in the ionic composition of the outer retina.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 57274 NCBI Gene Model | MGI Sequence Detail 3733 C57BL/6J ±  kb
transcript NM_020516 RefSeq | MGI Sequence Detail 1887 Not Specified  
polypeptide O35308 UniProt | EBI | MGI Sequence Detail 492 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 8
    cDNA 5
    Primer pair 3

    Microarray probesets 4
References
more
  • Summaries
    All 54
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 6
    Phenotypes 22
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:233611 Hirata A, et al., Homeobox family Hoxc localization during murine palate formation. Congenit Anom (Kyoto). 2016 Jul;56(4):172-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory