About   Help   FAQ
Litaf Gene Detail
Summary
  • Symbol
    Litaf
  • Name
    LPS-induced TN factor
  • Synonyms
    3222402J11Rik, N4WBP3, Nedd4 WW domain-binding protein 3, TBX1 protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929512
    NCBI Gene: 56722
  • Gene Overview
    MyGene.info: LITAF
Location & Maps
more
  • Sequence Map
    Chr16:10959275-11066157 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      106883 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 6.28 cM, cytoband B1-B3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    LITAF, lipopolysaccharide induced TNF factor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LITAF, lipopolysaccharide induced TNF factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PIG7, SIMPLE, TP53I7
  • Links
    NCBI Gene ID: 9516
    neXtProt AC: NX_Q99732

  • Chr Location
    16p13.13; chr16:11547722-11636377 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 37974
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LITAF
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LITAF associations

Human Disease Mouse Models
       Charcot-Marie-Tooth Disease, Demyelinating, Type 1C; CMT1C   OMIM: 601098 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    16
  • Targeted
    3
  • Transgenic
    1
  • Incidental Mutations
Homozygous ablation of this gene in macrophages results in reduced cytokine secretion in response to LPS stimulation, and increased resistance to LPS-induced septic shock.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026365 VEGA Gene Model | MGI Sequence Detail 106883 C57BL/6J ±  kb
transcript OTTMUST00000065202 VEGA | MGI Sequence Detail 2235 Not Applicable  
polypeptide OTTMUSP00000032457 VEGA | MGI Sequence Detail 161 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    491 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009843 lipopolysaccharide-induced tumor necrosis factor-alpha factor
  • InterPro Domains
    IPR006629 LPS-induced tumour necrosis factor alpha factor
Molecular
Reagents
less
  • All nucleic 194
    cDNA 190
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGI:1913928, MGI:2146720
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:195246 Lee SM, et al., Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol. 2012 Nov 26;199(5):799-816

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory