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Litaf
Gene Detail
 Symbol
Name
ID
Litaf
LPS-induced TN factor
MGI:1929512
Synonyms 3222402J11Rik, N4WBP3, Nedd4 WW domain-binding protein 3, TBX1 protein
Feature Type protein coding gene
Genetic Map
Chromosome 16
6.28 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:10959275-11066157 bp, - strand
From VEGA annotation of GRCm38

  106883 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Litaf

Human
homologs
Human Homolog LITAF, lipopolysaccharide-induced TNF factor
NCBI Gene ID 9516
neXtProt AC  NX_Q99732
Human Synonyms  PIG7, SIMPLE, TP53I7
Human Chr (Location)  16p13.13; chr16:11547722-11587466 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LITAF
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous ablation of this gene in macrophages results in reduced cytokine secretion in response to LPS stimulation, and increased resistance to LPS-induced septic shock.
 
Interactions
Litaf interacts with 182 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process apoptotic process, cellular response to lipopolysaccharide, ...
Component cytoplasm, Golgi apparatus, ...
Function protein binding, signal transducer activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (145)    Tissues (51)    Images (30)
Theiler Stages: 10, 18, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 130
Northern blot 12
RT-PCR 3
cDNA source data(188)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(194) cDNA(190) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000026365 (Evidence)
Ensembl Gene ModelENSMUSG00000022500 (Evidence)
Entrez Gene56722 (Evidence)
UniGene294753
DFCITC1572487
DoTSDT.535637
NIA Mouse Gene IndexU036788
Consensus CDS ProjectCCDS27958.1
International Mouse Knockout Project StatusLitaf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026365 VEGA Gene Model | MGI Sequence Detail 106883 C57BL/6J ±  kb
transcript OTTMUST00000065202 VEGA | MGI Sequence Detail 2235 Not Applicable 
polypeptide OTTMUSP00000032457 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(493 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006629 LPS-induced tumor necrosis factor alpha factor
Protein Ontology PR:000009843 lipopolysaccharide-induced tumor necrosis factor-alpha factor
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:195246 Lee SM, et al., Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking. J Cell Biol. 2012 Nov 26;199(5):799-816
All references(47)
Other
accession IDs
MGI:1913928, MGI:2146720

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory