Litaf
Gene Detail

Symbol Name ID

Litaf LPS-induced TN factor MGI:1929512

Synonyms

3222402J11Rik, N4WBP3, Nedd4 WW domain-binding protein 3, TBX1 protein

Feature Type

protein coding gene

Genetic Map

Chromosome 16

6.28 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:10959275-11066157 bp, - strand From VEGA annotation of GRCm38   106883 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Litaf

Human homologs

Human Homolog		LITAF, lipopolysaccharide-induced TNF factor
NCBI Gene ID		9516
neXtProt AC		NX_Q99732
Human Synonyms		PIG7, SIMPLE, TP53I7
Human Chr (Location)		16p13.13; chr16:11641578-11681322 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LITAF

Alleles and phenotypes

All alleles(19) : Targeted(3) Gene trapped(16)
 

Homozygous ablation of this gene in macrophages results in reduced cytokine secretion in response to LPS stimulation, and increased resistance to LPS-induced septic shock.

 

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	apoptotic process, cellular response to lipopolysaccharide, ...
Component	Golgi apparatus, lysosomal membrane, ...
Function	protein binding, signal transducer activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (145)    Tissues (50)    Images (30)
Theiler Stages: 10, 18, 23, 24, 25, 28

Assay Type	Results
RNA in situ	130
Northern blot	12
RT-PCR	3

cDNA source data(187)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(193) cDNA(189) Primer pair(4)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000026365 (Evidence)
Ensembl Gene Model	ENSMUSG00000022500 (Evidence)
Entrez Gene	56722 (Evidence)
UniGene	294753
DFCI	TC1572487
DoTS	DT.535637
NIA Mouse Gene Index	U036788
Consensus CDS Project	CCDS27958.1
International Mouse Knockout Project Status	Litaf

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026365	VEGA Gene Model | MGI Sequence Detail	106883	C57BL/6J
transcript	OTTMUST00000065202	VEGA | MGI Sequence Detail	2235	Not Applicable
polypeptide	OTTMUSP00000032457	VEGA | MGI Sequence Detail	161	Not Applicable

All sequences(42) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006629	LPS-induced tumor necrosis factor alpha factor
Protein Ontology	PR:000009843	lipopolysaccharide-induced tumor necrosis factor-alpha factor

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:186411 Somandin C, et al., LITAF (SIMPLE) regulates Wallerian degeneration after injury but is not essential for peripheral nerve development and maintenance: Implications for Charcot-Marie-Tooth disease. Glia. 2012 Oct;60(10):1518-28
All references(46)

Other accession IDs

MGI:1913928, MGI:2146720