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Ndufa1 Gene Detail
Summary
  • Symbol
    Ndufa1
  • Name
    NADH:ubiquinone oxidoreductase subunit A1
  • Synonyms
    1810049F12Rik, MWFE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929511
    NCBI Gene: 54405
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:37187588-37191163 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 21.61 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    8 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929511
protein coding gene ChrX:37187588-37191238 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035634
protein coding gene ChrX:32137986-32141554 (-)
A/J MGP_AJ_G0035611
protein coding gene ChrX:32203721-32207280 (-)
AKR/J MGP_AKRJ_G0035544
protein coding gene ChrX:32943795-32947365 (-)
BALB/cJ MGP_BALBcJ_G0035604
protein coding gene ChrX:31922934-31926523 (-)
C3H/HeJ MGP_C3HHeJ_G0035322
protein coding gene ChrX:32448785-32456417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036140
protein coding gene ChrX:32774367-32777986 (-)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0034612
protein coding gene ChrX:20608391-20611964 (-)
CBA/J MGP_CBAJ_G0035291
protein coding gene ChrX:33646336-33649901 (-)
DBA/2J MGP_DBA2J_G0035442
protein coding gene ChrX:32017905-32021797 (-)
FVB/NJ MGP_FVBNJ_G0035389
protein coding gene ChrX:31781586-31785151 (-)
LP/J MGP_LPJ_G0035524
protein coding gene ChrX:32535999-32539578 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035433
protein coding gene ChrX:34077872-34081436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036147
protein coding gene ChrX:32109151-32112720 (-)
PWK/PhJ MGP_PWKPhJ_G0034314
protein coding gene ChrX:20056686-20060265 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034155
protein coding gene ChrX:21085226-21088733 (-)
WSB/EiJ MGP_WSBEiJ_G0034748
protein coding gene ChrX:31900747-31906472 (-)



Homology
more
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CI-MWFE, MWFE, ZNF183
  • Links
    NCBI Gene ID: 4694
    neXtProt AC: NX_O15239
    UniProt: O15239

  • Chr Location
    Xq24; chrX:119871771-119876666 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ndufa1 mouse models; 1 with human NDUFA1 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016427 Ensembl Gene Model | MGI Sequence Detail 3576 C57BL/6J ±  kb
    transcript ENSMUST00000016571 Ensembl | MGI Sequence Detail 419 Not Applicable  
    polypeptide ENSMUSP00000016571 Ensembl | MGI Sequence Detail 70 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011067 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
    • PDB
    • InterPro Domains
      IPR017384 NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1
    Molecular
    Reagents
    less
    • All nucleic 151
      cDNA 151

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923962
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 5
      Phenotypes 3
    • Earliest
      J:66313 Frattini A, et al., Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. Gene. 1997 Jun 19;192(2):291-8
    • Latest
      J:257477 Kim C, et al., An X-chromosome linked mouse model (Ndufa1(S55A)) for systemic partial Complex I deficiency for studying predisposition to neurodegeneration and other diseases. Neurochem Int. 2017 Oct;109:78-93

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory