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Ndufa1 Gene Detail
Summary
  • Symbol
    Ndufa1
  • Name
    NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1
  • Synonyms
    1810049F12Rik, MWFE
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929511
    NCBI Gene: 54405
Location & Maps
more
  • Sequence Map
    ChrX:37187588-37191163 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3576 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 21.61 cM, cytoband A2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
  • Vertebrate Orthologs
    14
  • Human Ortholog
    NDUFA1, NADH:ubiquinone oxidoreductase subunit A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CI-MWFE, MWFE, ZNF183
  • Links
    NCBI Gene ID: 4694
    neXtProt AC: NX_O15239

  • Chr Location
    Xq24; chrX:119871771-119876666 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human NDUFA1 associations

Human Disease Mouse Models
       Mitochondrial Complex I Deficiency   OMIM: 252010
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotype references
  • All Mutations and Alleles
    1
  • Gene trapped
    1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017127 VEGA Gene Model | MGI Sequence Detail 3576 C57BL/6J ±  kb
transcript OTTMUST00000041470 VEGA | MGI Sequence Detail 419 Not Applicable  
polypeptide OTTMUSP00000018617 VEGA | MGI Sequence Detail 70 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011067 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1
  • InterPro Domains
    IPR017384 NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex subunit 1
Molecular
Reagents
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  • All nucleic 150
    cDNA 150

    Microarray probesets 4
Other
Accession IDs
less
MGI:1923962
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:66313 Frattini A, et al., Identification of a new member (ZNF183) of the Ring finger gene family in Xq24-25. Gene. 1997 Jun 19;192(2):291-8
  • Latest
    J:172354 Wirtz S, et al., Region-Specific Expression of Mitochondrial Complex I Genes during Murine Brain Development. PLoS One. 2011;6(4):e18897

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory