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Arl6ip5 Gene Detail
Summary
  • Symbol
    Arl6ip5
  • Name
    ADP-ribosylation factor-like 6 interacting protein 5
  • Synonyms
    5930404D22Rik, addiscin, Aip-5, Gtrap3-18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929501
    NCBI Gene: 65106
  • Gene Overview
    MyGene.info: ARL6IP5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:97210792-97233315 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 44.91 cM, cytoband D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929501
protein coding gene Chr6:97210689-97233315 (.)
129S1/SvImJ MGP_129S1SvImJ_G0031075
protein coding gene Chr6:99040665-99064392 (+)
A/J MGP_AJ_G0031044
protein coding gene Chr6:95296968-95319948 (+)
AKR/J MGP_AKRJ_G0030975
protein coding gene Chr6:97917773-97941766 (+)
BALB/cJ MGP_BALBcJ_G0031055
protein coding gene Chr6:95254442-95280150 (+)
C3H/HeJ MGP_C3HHeJ_G0030653
protein coding gene Chr6:86491158-86515593 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031514
protein coding gene Chr6:101554693-101580865 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028679
protein coding gene Chr6:93154204-93177642 (+)
CAST/EiJ MGP_CASTEiJ_G0030162
protein coding gene Chr6:98090942-98118124 (+)
CBA/J MGP_CBAJ_G0030741
protein coding gene Chr6:105427241-105457112 (+)
DBA/2J MGP_DBA2J_G0030894
protein coding gene Chr6:94438036-94461105 (+)
FVB/NJ MGP_FVBNJ_G0030848
protein coding gene Chr6:93616728-93641079 (+)
LP/J MGP_LPJ_G0030974
protein coding gene Chr6:99073737-99100751 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030882
protein coding gene Chr6:109338833-109363591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031541
protein coding gene Chr6:97787925-97813600 (+)
PWK/PhJ MGP_PWKPhJ_G0029878
protein coding gene Chr6:93415229-93438411 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029706
protein coding gene Chr6:96684571-96713483 (+)
WSB/EiJ MGP_WSBEiJ_G0030246
protein coding gene Chr6:98254849-98277470 (+)



Homology
more
  • Human Ortholog
    ARL6IP5, ADP ribosylation factor like GTPase 6 interacting protein 5
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARL6IP5, ADP ribosylation factor like GTPase 6 interacting protein 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    addicsin, DERP11, GTRAP3-18, hp22, HSPC127, jmx, JWA, PRAF3, Yip6b
  • Links
    NCBI Gene ID: 10550
    neXtProt AC: NX_O75915
    UniProt: O75915

  • Chr Location
    3p14.1; chr3:69084939-69106088 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased resistance to oxidative stress hypoactivity, enhanced motor coordination and learning, and enhanced spatial working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 65106 NCBI Gene Model | MGI Sequence Detail 22524 C57BL/6J ±  kb
    transcript NM_022992 RefSeq | MGI Sequence Detail 1339 C57BL/6  
    polypeptide Q8R5J9 UniProt | EBI | MGI Sequence Detail 188 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      cDNA 98

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1915343, MGI:2141607
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
    • Latest
      J:233362 Wu Y, et al., Deficiency of osteoblastic Arl6ip5 impaired osteoblast differentiation and enhanced osteoclastogenesis via disturbance of ER calcium homeostasis and induction of ER stress-mediated apoptosis. Cell Death Dis. 2014;5:e1464

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory