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Arl6ip5
Gene Detail
 Symbol
Name
ID
Arl6ip5
ADP-ribosylation factor-like 6 interacting protein 5
MGI:1929501
Synonyms 5930404D22Rik, addiscin, Aip-5, Gtrap3-18
Feature Type protein coding gene
Genetic Map
Chromosome 6
44.91 cM, cytoband D3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:97210689-97233315 bp, + strand
From VEGA annotation of GRCm38

  22627 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4673  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Arl6ip5

Human
homologs
Human Homolog ARL6IP5, ADP-ribosylation factor-like 6 interacting protein 5
NCBI Gene ID 10550
neXtProt AC  NX_O75915
Human Synonyms  addicsin, DERP11, GTRAP3-18, hp22, jmx, JWA, PRAF3
Human Chr (Location)  3p14; chr3:69084939-69106088 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(9) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit increased resistance to oxidative stressm hypoactivity, enhanced motor coordination and learning, and enhanced spatial working memory.
 
Phenotype Images(1)
Interactions
Arl6ip5 interacts with 115 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process intrinsic apoptotic signaling pathway in response to oxidative stress, L-glutamate transport, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 3
cDNA source data(96)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(97) cDNA(97)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023411 (Evidence)
Ensembl Gene ModelENSMUSG00000035199 (Evidence)
Entrez Gene65106 (Evidence)
UniGene291014
DFCITC1574201
DoTSDT.533749
NIA Mouse Gene IndexU007211
Consensus CDS ProjectCCDS20384.1
International Mouse Knockout Project StatusArl6ip5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023411 VEGA Gene Model | MGI Sequence Detail 22627 C57BL/6J ±  kb
transcript OTTMUST00000056870 VEGA | MGI Sequence Detail 1442 Not Applicable 
polypeptide OTTMUSP00000027382 VEGA | MGI Sequence Detail 188 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(96 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004895 Prenylated rab acceptor PRA1
Protein Ontology PR:000004293 PRA1 family protein 3
References (Earliest) J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
(Latest) J:187133 Gong Z, et al., JWA deficiency suppresses dimethylbenz[a]anthracene-phorbol ester induced skin papillomas via inactivation of MAPK pathway in mice. PLoS One. 2012;7(3):e34154
All references(42)
Other
accession IDs
MGI:1915343, MGI:2141607

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory