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Arhgap35
Gene Detail
 Symbol
Name
ID
Arhgap35
Rho GTPase activating protein 35
MGI:1929494
Synonyms 6430596G11Rik, Grlf1, p190A, p190RhoGAP, P190 RhoGAP
Feature Type protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:16494473-16614993 bp, - strand
From NCBI annotation of GRCm38

  120521 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Arhgap35

Human
homologs
Human Homolog ARHGAP35, Rho GTPase activating protein 35
NCBI Gene ID 2909
neXtProt AC  NX_Q9NRY4
Human Synonyms  GRF-1, GRLF1, P190A, P190-A, p190ARhoGAP, p190RhoGAP
Human Chr (Location)  19q13.3; chr19:46918676-47005077 (+)  GRCh38
Alleles
and
phenotypes
All alleles(43) : Chemically induced (ENU)(1) Gene trapped(39) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks. Abnormalities are seen in the retina and in the development of the brain and nervous system.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process camera-type eye development, forebrain development, ...
Component actin cytoskeleton, cytoplasm, ...
Function DNA binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (12)    Tissues (2)   
Theiler Stages: 24, 28
Assay TypeResults
Western blot 12
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000058230 (Evidence)
Entrez Gene232906 (Evidence)
DFCITC1576346, TC1597118, TC1599031
DoTSDT.101378666, DT.493154
NIA Mouse Gene IndexU028187
Consensus CDS ProjectCCDS20851.1
International Mouse Knockout Project StatusArhgap35
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 232906 NCBI Gene Model | MGI Sequence Detail 120521 C57BL/6J ±  kb
transcript NM_172739 RefSeq | MGI Sequence Detail 8393 C57BL/6 
polypeptide Q91YM2 UniProt | EBI | MGI Sequence Detail 1499 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(6)
Polymorphisms SNPs within 2kb(804 from dbSNP Build 137)    SNPs within 2kb including multiple locations(806)
Protein-related
information
ResourceIDDescription
InterPro IPR002713 FF domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001806 Small GTPase superfamily
Protein Ontology PR:000008262 rho GTPase-activating protein 35
Graphical View of Protein Domain Structure
References (Earliest) J:65296 Brouns MR, et al., The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov;127(22):4891-903
(Latest) J:181612 Gourley SL, et al., Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. J Neurosci. 2012 Feb 15;32(7):2314-23
All references(50)
Other
accession IDs
MGI:2142039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory