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Arhgap35
Gene Detail
Symbol

Name
ID
Arhgap35
Rho GTPase activating protein 35
MGI:1929494
Synonyms
6430596G11Rik, Grlf1, p190A, p190RhoGAP, P190 RhoGAP
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:16493719-16614993 bp, - strand
From VEGA annotation of GRCm38

  121275 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:35136  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ARHGAP35
Gene Tree: Arhgap35

Human
homologs
ARHGAP35, Rho GTPase activating protein 35
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2909
neXtProt AC: NX_Q9NRY4

Human Synonyms: GRF-1, GRLF1, P190A, P190-A, p190ARhoGAP, p190RhoGAP

Human Chr (Location): 19q13.3; chr19:46918567-47005077 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Chemically induced (ENU)(1) Gene trapped(39) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks. Abnormalities are seen in the retina and in the development of the brain and nervous system.
 
Interactions
Arhgap35 interacts with 377 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process camera-type eye development, forebrain development, ...
Component actin cytoskeleton, cytoplasm, ...
Function DNA binding, GTPase activating protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (12)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Western blot 12
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase arhgap35    NEW 
Molecular
reagents
All nucleic(11) cDNA(11)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048052 (Evidence)
Ensembl Gene Model ENSMUSG00000058230 (Evidence)
Entrez Gene 232906 (Evidence)
DFCI TC1599031, TC1597118, TC1576346
DoTS DT.101378666, DT.493154
NIA Mouse Gene Index U028187
Consensus CDS Project CCDS20851.1
International Mouse Phenotyping Consortium Status Arhgap35
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048052 VEGA Gene Model | MGI Sequence Detail 121275 C57BL/6J ±  kb
transcript OTTMUST00000123490 VEGA | MGI Sequence Detail 9147 Not Applicable 
polypeptide OTTMUSP00000067426 VEGA | MGI Sequence Detail 1499 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(6) UniProt(7)
Polymorphisms
SNPs within 2kb(808 from dbSNP Build 137)    SNPs within 2kb including multiple locations(810)
Protein-related
information
ResourceIDDescription
InterPro IPR002713 FF domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR000198 Rho GTPase-activating protein domain
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001806 Small GTPase superfamily
Protein Ontology PR:000008262 rho GTPase-activating protein 35
References
(Earliest) J:65296 Brouns MR, et al., The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov;127(22):4891-903
(Latest) J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54
All references(53)
Other
accession IDs
MGI:2142039

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory