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Arhgap35 Gene Detail
Summary
  • Symbol
    Arhgap35
  • Name
    Rho GTPase activating protein 35
  • Synonyms
    6430596G11Rik, Grlf1, p190A, p190RhoGAP, P190 RhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929494
    NCBI Gene: 232906
  • Gene Overview
    MyGene.info: ARHGAP35
Location & Maps
more
  • Sequence Map
    Chr7:16493719-16614993 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      121275 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ARHGAP35, Rho GTPase activating protein 35
  • Vertebrate Orthologs
    11
  • Human Ortholog
    ARHGAP35, Rho GTPase activating protein 35
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GRF-1, GRLF1, P190A, P190-A, p190ARhoGAP, p190RhoGAP
  • Links
    NCBI Gene ID: 2909
    neXtProt AC: NX_Q9NRY4

  • Chr Location
    19q13.3; chr19:46918567-47005077 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    43
  • Chemically induced (ENU)
    1
  • Gene trapped
    39
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks. Abnormalities are seen in the retina and in the development of the brain and nervous system.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048052 VEGA Gene Model | MGI Sequence Detail 121275 C57BL/6J ±  kb
transcript OTTMUST00000123490 VEGA | MGI Sequence Detail 9147 Not Applicable  
polypeptide OTTMUSP00000067426 VEGA | MGI Sequence Detail 1499 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    798 from dbSNP Build 142
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008262 rho GTPase-activating protein 35
  • InterPro Domains
    IPR002713 FF domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000198 Rho GTPase-activating protein domain
    IPR032835 Rho GTPase-activating protein, FF domain
    IPR008936 Rho GTPase activation protein
    IPR001806 Small GTPase superfamily
Molecular
Reagents
less
  • All nucleic 11
    cDNA 11

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142039
References
more
  • Summaries
    All 50
    Developmental Gene Expression 8
    Gene Ontology 9
    Phenotypes 14
  • Earliest
    J:65296 Brouns MR, et al., The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov;127(22):4891-903
  • Latest
    J:217675 Gao Z, et al., An AUTS2-Polycomb complex activates gene expression in the CNS. Nature. 2014 Dec 18;516(7531):349-54

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory