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Atl2 Gene Detail
Summary
  • Symbol
    Atl2
  • Name
    atlastin GTPase 2
  • Synonyms
    2010110I21Rik, Aip-2, Arl6ip2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929492
    NCBI Gene: 56298
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:79848390-79896123 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 50.30 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929492
protein coding gene Chr17:79848352-79896123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024054
protein coding gene Chr17:82725309-82774441 (-)
A/J MGP_AJ_G0024011
protein coding gene Chr17:80185480-80233199 (-)
AKR/J MGP_AKRJ_G0023980
protein coding gene Chr17:81412821-81465700 (-)
BALB/cJ MGP_BALBcJ_G0024013
protein coding gene Chr17:80071354-80123230 (-)
C3H/HeJ MGP_C3HHeJ_G0023777
protein coding gene Chr17:82316005-82365034 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024457
protein coding gene Chr17:85743197-85797852 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021899
protein coding gene Chr17:75571619-75619698 (-)
CAST/EiJ MGP_CASTEiJ_G0023257
protein coding gene Chr17:82960545-83013672 (-)
CBA/J MGP_CBAJ_G0023751
protein coding gene Chr17:89308312-89364391 (-)
DBA/2J MGP_DBA2J_G0023880
protein coding gene Chr17:78709525-78756244 (-)
FVB/NJ MGP_FVBNJ_G0023846
protein coding gene Chr17:78203551-78250903 (-)
LP/J MGP_LPJ_G0023963
protein coding gene Chr17:83574473-83623714 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023874
protein coding gene Chr17:89379942-89429582 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024502
protein coding gene Chr17:81895687-81946743 (-)
PWK/PhJ MGP_PWKPhJ_G0023003
protein coding gene Chr17:78218573-78266544 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022814
protein coding gene Chr17:78696718-78746624 (-)
WSB/EiJ MGP_WSBEiJ_G0023324
protein coding gene Chr17:82730663-82780507 (-)



Homology
more
  • Human Ortholog
    ATL2, atlastin GTPase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATL2, atlastin GTPase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    aip-2, ARL3IP2, ARL6IP2, atlastin2
  • Links
    NCBI Gene ID: 64225
    neXtProt AC: NX_Q8NHH9
    UniProt: Q8NHH9

  • Chr Location
    2p22.2-p22.1; chr2:38293957-38378579 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 56949
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ATL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059811 Ensembl Gene Model | MGI Sequence Detail 47734 C57BL/6J ±  kb
    transcript ENSMUST00000068282 Ensembl | MGI Sequence Detail 3618 Not Applicable  
    polypeptide ENSMUSP00000064758 Ensembl | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 110
      cDNA 109
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917510, MGI:2146739, MGI:2147027
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 4
      Phenotypes 9
    • Earliest
      J:62458 Ingley E, et al., A novel ADP-ribosylation like factor (ARL-6), interacts with the protein-conducting channel SEC61beta subunit. FEBS Lett. 1999 Oct 1;459(1):69-74
    • Latest
      J:260950 Zhao G, et al., Mammalian knock out cells reveal prominent roles for atlastin GTPases in ER network morphology. Exp Cell Res. 2016 Nov 15;349(1):32-44

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory