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Irak1bp1 Gene Detail
Summary
  • Symbol
    Irak1bp1
  • Name
    interleukin-1 receptor-associated kinase 1 binding protein 1
  • Synonyms
    4921528N06Rik, AIP70, SIMPL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929475
    NCBI Gene: 65099
Location & Maps
more
  • Sequence Map
    Chr9:82829540-82847687 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18148 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 45.16 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    IRAK1BP1, interleukin 1 receptor associated kinase 1 binding protein 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IRAK1BP1, interleukin 1 receptor associated kinase 1 binding protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AIP70, SIMPL
  • Links
    NCBI Gene ID: 134728
    neXtProt AC: NX_Q5VVH5

  • Chr Location
    6q14.1; chr6:78867085-78936160 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    2
  • Genomic Mutations
    1 involving Irak1bp1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044898 VEGA Gene Model | MGI Sequence Detail 18148 C57BL/6J ±  kb
transcript OTTMUST00000118004 VEGA | MGI Sequence Detail 2158 Not Applicable  
polypeptide OTTMUSP00000065909 VEGA | MGI Sequence Detail 259 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    102 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009101 interleukin-1 receptor-associated kinase 1-binding protein 1
  • InterPro Domains
    IPR030312 Interleukin-1 receptor-associated kinase 1-binding protein 1
    IPR007497 Protein of unknown function DUF541
Molecular
Reagents
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  • All nucleic 27
    cDNA 27

    Microarray probesets 4
Other
Accession IDs
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MGI:1913981, MGI:2143152
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 8
  • Earliest
    J:66320 Pfeuffer T, et al., LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes. Cell Microbiol. 2000 Apr;2(2):101-14
  • Latest
    J:200629 Zhao W, et al., SIMPL enhancement of tumor necrosis factor-alpha dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function. PLoS One. 2013;8(4):e61123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory