Rgr
Gene Detail

Symbol Name ID

Rgr retinal G protein coupled receptor MGI:1929473

Synonyms

RGR opsin

Feature Type

protein coding gene

Genetic Map

Chromosome 14

21.29 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr14:37037490-37048964 bp, - strand From NCBI annotation of GRCm38   11475 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: RPE-retinal G protein-coupled receptor
Gene Tree: Rgr

Human homologs

Human Homolog		RGR, retinal G protein coupled receptor
NCBI Gene ID		5995
neXtProt AC		NX_P47804
Human Synonyms		RP44
Human Chr (Location)		10q23; chr10:86004809-86018944 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RGR

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation, following 8 hours of light, exhibit reductions in both total retinal (mostly 11-cis-retinal) and rhodopsin levels, and over-accumulate all-trans-retinal indicating an impaired visual cycle.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	G-protein coupled receptor signaling pathway, phototransduction, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	G-protein coupled receptor activity, photoreceptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (6)   
Theiler Stages: 17, 19, 20, 21, 23, 28

Assay Type	Results
RT-PCR	15

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000021804 (Evidence)
Entrez Gene	57811 (Evidence)
UniGene	20460
DFCI	TC1579993
DoTS	DT.97346547
NIA Mouse Gene Index	U035423
Consensus CDS Project	CCDS26949.1
International Mouse Knockout Project Status	Rgr

Sequences

Length	Strain/Species
genomic	57811	NCBI Gene Model | MGI Sequence Detail	11475	C57BL/6J
transcript	NM_021340	RefSeq | MGI Sequence Detail	1659	C57BL/6
polypeptide	Q9Z2B3	UniProt | EBI | MGI Sequence Detail	291	Not Applicable

All sequences(19) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(122 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR001793	Retinal pigment epithelium GPCR
Protein Ontology	PR:000001437	RPE-retinal G protein-coupled receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:53187 Tao L, et al., Structure and developmental expression of the mouse RGR opsin gene. Mol Vis. 1998 Dec 2;4:25
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)