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Rgr
Gene Detail
 Symbol
Name
ID
Rgr
retinal G protein coupled receptor
MGI:1929473
Synonyms RGR opsin
Feature Type protein coding gene
Genetic Map
Chromosome 14
21.29 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:37037490-37048964 bp, - strand
From NCBI annotation of GRCm38

  11475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: RPE-retinal G protein-coupled receptor
Gene Tree: Rgr

Human
homologs
Human Homolog RGR, retinal G protein coupled receptor
NCBI Gene ID 5995
neXtProt AC  NX_P47804
Human Synonyms  RP44
Human Chr (Location)  10q23; chr10:84245053-84259188 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RGR
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation, following 8 hours of light, exhibit reductions in both total retinal (mostly 11-cis-retinal) and rhodopsin levels, and over-accumulate all-trans-retinal indicating an impaired visual cycle.
 
Interactions
Rgr interacts with 118 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chemotaxis, G-protein coupled receptor signaling pathway, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function chemokine receptor activity, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (6)   
Theiler Stages: 17, 19, 20, 21, 23, 28
Assay TypeResults
RT-PCR 15
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021804 (Evidence)
Entrez Gene57811 (Evidence)
UniGene20460
DFCITC1579993
DoTSDT.97346547
NIA Mouse Gene IndexU035423
Consensus CDS ProjectCCDS26949.1
International Mouse Knockout Project StatusRgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 57811 NCBI Gene Model | MGI Sequence Detail 11475 C57BL/6J ±  kb
transcript NM_021340 RefSeq | MGI Sequence Detail 1659 C57BL/6 
polypeptide Q9Z2B3 UniProt | EBI | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001793 Retinal pigment epithelium GPCR
Protein Ontology PR:000001437 RPE-retinal G protein-coupled receptor
Graphical View of Protein Domain Structure
References (Earliest) J:53187 Tao L, et al., Structure and developmental expression of the mouse RGR opsin gene. Mol Vis. 1998 Dec 2;4:25
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(31)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory