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Rgr
Gene Detail
Symbol

Name
ID
Rgr
retinal G protein coupled receptor
MGI:1929473
Synonyms
RGR opsin
Feature Type
protein coding gene
Genetic Map
Chromosome 14
21.29 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:37037490-37048964 bp, - strand
From Ensembl annotation of GRCm38

  11475 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37709  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGR
Protein SuperFamily: RPE-retinal G protein-coupled receptor
Gene Tree: Rgr

Human
homologs
RGR, retinal G protein coupled receptor
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5995
neXtProt AC: NX_P47804

Human Synonyms: RP44

Human Chr (Location): 10q23; chr10:84237083-84259347 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RGR

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation, following 8 hours of light, exhibit reductions in both total retinal (mostly 11-cis-retinal) and rhodopsin levels, and over-accumulate all-trans-retinal indicating an impaired visual cycle.
 
Interactions
Rgr interacts with 118 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 15
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA RGR ; Xenbase rgr ; ZFIN rgra, rgrb    NEW 
Molecular
reagents
All nucleic(10) cDNA(9) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021804 (Evidence)
Entrez Gene 57811 (Evidence)
UniGene 20460
DFCI TC1645039, TC1579993, TC1710150
DoTS DT.97346547, DT.110777963, DT.102557991
NIA Mouse Gene Index U035423
Consensus CDS Project CCDS26949.1
International Mouse Phenotyping Consortium Status Rgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021804 Ensembl Gene Model | MGI Sequence Detail 11475 C57BL/6J ±  kb
transcript ENSMUST00000022338 Ensembl | MGI Sequence Detail 1659 Not Applicable 
polypeptide ENSMUSP00000022338 Ensembl | MGI Sequence Detail 291 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR001793 Retinal pigment epithelium GPCR
Protein Ontology PR:000001437 RPE-retinal G protein-coupled receptor
References
(Earliest) J:53187 Tao L, et al., Structure and developmental expression of the mouse RGR opsin gene. Mol Vis. 1998 Dec 2;4:25
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory