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Rgr Gene Detail
Summary
  • Symbol
    Rgr
  • Name
    retinal G protein coupled receptor
  • Synonyms
    RGR opsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929473
    NCBI Gene: 57811
Location & Maps
more
  • Sequence Map
    Chr14:37037490-37048964 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11475 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 21.29 cM, cytoband B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RGR, retinal G protein coupled receptor
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGR, retinal G protein coupled receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RP44
  • Links
    NCBI Gene ID: 5995
    neXtProt AC: NX_P47804

  • Chr Location
    10q23; chr10:84237083-84259347 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RGR associations

Human Disease Mouse Models
       Retinitis Pigmentosa 44; RP44   OMIM: 613769
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation, following 8 hours of light, exhibit reductions in both total retinal (mostly 11-cis-retinal) and rhodopsin levels, and over-accumulate all-trans-retinal indicating an impaired visual cycle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021804 Ensembl Gene Model | MGI Sequence Detail 11475 C57BL/6J ±  kb
transcript ENSMUST00000022338 Ensembl | MGI Sequence Detail 1659 Not Applicable  
polypeptide ENSMUSP00000022338 Ensembl | MGI Sequence Detail 291 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    224 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001437 RPE-retinal G protein-coupled receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR001793 Retinal pigment epithelium GPCR
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 27
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:53187 Tao L, et al., Structure and developmental expression of the mouse RGR opsin gene. Mol Vis. 1998 Dec 2;4:25
  • Latest
    J:226844 Collin GB, et al., Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Hum Mol Genet. 2015 Dec 15;24(24):6958-74

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory