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Myoz1 Gene Detail
Summary
  • Symbol
    Myoz1
  • Name
    myozenin 1
  • Synonyms
    2310001N11Rik, calsarcin-2, FATZ
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929471
    NCBI Gene: 59011
  • Gene Overview
    MyGene.info: MYOZ1
Location & Maps
more
  • Sequence Map
    Chr14:20649102-20656540 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7439 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 11.53 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    MYOZ1, myozenin 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MYOZ1, myozenin 1
    Orthology source: HomoloGene
  • Synonyms
    CS-2, FATZ, MYOZ
  • Links
    NCBI Gene ID: 58529
    neXtProt AC: NX_Q9NP98

  • Chr Location
    10q22.1; chr10:73631612-73641757 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 23311
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MYOZ1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    5
  • Targeted
    6
  • Incidental Mutations
Mice homozygous for a knock-out allele show reduced body weight and fast-twitch muscle mass, a fiber type shift toward more oxidative fibers, increased exercise capacity and calcineurin activity, and enhanced muscle regeneration after cardiotoxin injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 59011 NCBI Gene Model | MGI Sequence Detail 7439 C57BL/6J ±  kb
transcript NM_021508 RefSeq | MGI Sequence Detail 1294 C57BL/6  
polypeptide Q9JK37 UniProt | EBI | MGI Sequence Detail 296 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 29
    cDNA 28
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1916752, MGI:2145778
References
more
  • Summaries
    All 33
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:66484 Frey N, et al., Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14632-7
  • Latest
    J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory