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Myoz1
Gene Detail
 Symbol
Name
ID
Myoz1
myozenin 1
MGI:1929471
Synonyms 2310001N11Rik, calsarcin-2, FATZ
Feature Type protein coding gene
Genetic Map
Chromosome 14
11.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:20649102-20656540 bp, - strand
From NCBI annotation of GRCm38

  7439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23311  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Myoz1

Human
homologs
Human Homolog MYOZ1, myozenin 1
NCBI Gene ID 58529
neXtProt AC  NX_Q9NP98
Human Synonyms  CS-2, FATZ, MYOZ
Human Chr (Location)  10q22.1; chr10:73631612-73641757 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(5) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele show reduced body weight and fast-twitch muscle mass, a fiber type shift toward more oxidative fibers, increased exercise capacity and calcineurin activity, and enhanced muscle regeneration after cardiotoxin injury.
 
Interactions
Myoz1 interacts with 63 markers (Mir10a, Mir10b, Mir28b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Component actin cytoskeleton, cell projection, ...
Function FATZ binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (51)    Tissues (6)    Images (34)
Theiler Stages: 23
Assay TypeResults
RNA in situ 49
RT-PCR 2
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) cDNA(28) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000068697 (Evidence)
Entrez Gene59011 (Evidence)
UniGene439911
DFCITC1579666, TC1714269
DoTSDT.101702744, DT.110762198, DT.492733, DT.97385214
NIA Mouse Gene IndexU035283
Consensus CDS ProjectCCDS36819.1
International Mouse Knockout Project StatusMyoz1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 59011 NCBI Gene Model | MGI Sequence Detail 7439 C57BL/6J ±  kb
transcript NM_021508 RefSeq | MGI Sequence Detail 1294 C57BL/6 
polypeptide Q9JK37 UniProt | EBI | MGI Sequence Detail 296 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(31 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008438 Calcineurin-binding
Protein Ontology PR:000010882 myozenin-1
Graphical View of Protein Domain Structure
References (Earliest) J:66484 Frey N, et al., Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Proc Natl Acad Sci U S A. 2000 Dec 19;97(26):14632-7
(Latest) J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
All references(36)
Other
accession IDs
MGI:1916752, MGI:2145778

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory