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Tyk2
Gene Detail
 Symbol
Name
ID
Tyk2
tyrosine kinase 2
MGI:1929470
Synonyms JTK1
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.71 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:21104069-21127346 bp, - strand
From Ensembl annotation of GRCm38

  23278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Tyk2

Human
homologs
Human Homolog TYK2, tyrosine kinase 2
NCBI Gene ID 7297
neXtProt AC  NX_P29597
Human Synonyms  JTK1
Human Chr (Location)  19p13.2; chr19:10350528-10380572 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TYK2
Alleles
and
phenotypes
All alleles(9) : Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.
 
Human Diseases Modeled Using Mouse Tyk2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process intracellular signal transduction, phosphorylation, ...
Component cytoplasm, cytoskeleton, ...
Function ATP binding, growth hormone receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000032175 (Evidence)
Entrez Gene54721 (Evidence)
DFCITC1576453
DoTSDT.101128039, DT.101240965, DT.101356584, DT.527945, DT.97378530
EC2.7.10.2
PDB4E1Z, 4E20
Consensus CDS ProjectCCDS57656.1
International Mouse Knockout Project StatusTyk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032175 Ensembl Gene Model | MGI Sequence Detail 23278 C57BL/6J ±  kb
transcript ENSMUST00000001036 Ensembl | MGI Sequence Detail 4619 Not Applicable 
polypeptide ENSMUSP00000001036 Ensembl | MGI Sequence Detail 1207 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(7)
Polymorphisms SNPs within 2kb(130 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019749 Band 4.1 domain
InterPro IPR019748 FERM central domain
InterPro IPR000299 FERM domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016251 Tyrosine-protein kinase, non-receptor Jak/Tyk2
InterPro IPR016045 Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
Protein Ontology PR:000016874 non-receptor tyrosine-protein kinase TYK2
References (Earliest) J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
(Latest) J:205704 Smith CL, et al., IL-22 regulates iron availability in vivo through the induction of hepcidin. J Immunol. 2013 Aug 15;191(4):1845-55
All references(76)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory