Tyk2
Gene Detail

Symbol Name ID

Tyk2 tyrosine kinase 2 MGI:1929470

Synonyms

JTK1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

7.71 cM, cytoband A3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:21104069-21127346 bp, - strand From Ensembl annotation of GRCm38   23278 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20712  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, Jak/Tyk2 type
Gene Tree: Tyk2

Human homologs

Human Homolog		TYK2, tyrosine kinase 2
NCBI Gene ID		7297
neXtProt AC		NX_P29597
Human Synonyms		JTK1
Human Chr (Location)		19p13.2; chr19:10461204-10491248 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TYK2

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.

 

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	intracellular protein kinase cascade, phosphorylation, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, growth hormone receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000032175 (Evidence)
Entrez Gene	54721 (Evidence)
DFCI	TC1576453
DoTS	DT.101128039, DT.101240965, DT.101356584, DT.527945, DT.97378530
EC	2.7.10.2
PDB	4E1Z, 4E20
Consensus CDS Project	CCDS57656.1
International Mouse Knockout Project Status	Tyk2

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032175	Ensembl Gene Model | MGI Sequence Detail	23278	C57BL/6J
transcript	ENSMUST00000001036	Ensembl | MGI Sequence Detail	4619	Not Applicable
polypeptide	ENSMUSP00000001036	Ensembl | MGI Sequence Detail	1207	Not Applicable

All sequences(45) RefSeq(4) UniProt(7)

Polymorphisms

SNPs(106 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019749	Band 4.1 domain
InterPro	IPR019748	FERM central domain
InterPro	IPR000299	FERM domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2
InterPro	IPR016045	Tyrosine-protein kinase, non-receptor, TYK2, N-terminal
Protein Ontology	PR:000016874	non-receptor tyrosine-protein kinase TYK2

References

(Earliest) J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
(Latest) J:195099 Derecka M, et al., Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab. 2012 Dec 5;16(6):814-24
All references(73)