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Tyk2 Gene Detail
Summary
  • Symbol
    Tyk2
  • Name
    tyrosine kinase 2
  • Synonyms
    JTK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929470
    NCBI Gene: 54721
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21015364-21042539 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.71 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929470
 protein coding gene Chr9:21015364-21042689 (-)
129S1/SvImJ ENSMUSG00200045124
 protein coding gene Chr9:17968983-17996499 (-)
A/J ENSMUSG00195038335
 protein coding gene Chr9:17805678-17833192 (-)
AKR/J ENSMUSG00220031948
 protein coding gene Chr9:17808145-17835818 (-)
BALB/cJ ENSMUSG00180038731
 protein coding gene Chr9:17939964-17967633 (-)
C3H/HeJ ENSMUSG00175035945
 protein coding gene Chr9:17902328-17930001 (-)
C57BL/6NJ ENSMUSG00215034177
 protein coding gene Chr9:17899838-17927510 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031861
 protein coding gene Chr9:17113672-17141417 (-)
CAST/EiJ ENSTCUG00005028202
 protein coding gene Chr9:17933098-17959734 (-)
CBA/J ENSMUSG00210038439
 protein coding gene Chr9:17883349-17910858 (-)
DBA/2J ENSMUSG00185024184
 protein coding gene Chr9:17998812-18026480 (-)
FVB/NJ ENSMUSG00205024459
 protein coding gene Chr9:18231869-18259381 (-)
JF1/MsJ ENSUMUG00000026476
 protein coding gene Chr9:18108614-18135647 (-)
LP/J ENSMUSG00230040829
 protein coding gene Chr9:18390186-18417687 (-)
NOD/ShiLtJ ENSMUSG00190035537
 protein coding gene Chr9:17923815-17951319 (-)
NZO/HlLtJ ENSMUSG00225049919
 protein coding gene Chr9:18340774-18368278 (-)
PWK/PhJ ENSLUMG00010037890
 protein coding gene Chr9:17998670-18025669 (-)
SPRET/EiJ ENSMSPG00010021519
 protein coding gene Chr9:18226581-18253128 (-)
WSB/EiJ ENSIUOG00005036779
 protein coding gene Chr9:17469831-17497111 (-)



Homology
more
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Synonyms
    IMD35, JTK1
  • Links
    NCBI Gene ID: 7297
    UniProt: P29597

  • Chr Location
    19p13.2; chr19:10350528-10380608 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tyk2 mouse models; 1 with human TYK2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 6 alleles in 8 genetic backgrounds
    2 phenotypes from multigenic genotypes
    74 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    63
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032175 Ensembl Gene Model | MGI Sequence Detail 27176 C57BL/6J ±  kb
    transcript ENSMUST00000001036 Ensembl | MGI Sequence Detail 4619 Not Applicable  
    polypeptide ENSMUSP00000001036 Ensembl | MGI Sequence Detail 1207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 74
    • Earliest
      J:19806 Harpur AG, et al., JAK2, a third member of the JAK family of protein tyrosine kinases. Oncogene. 1992 Jul;7(7):1347-53
    • Latest
      J:377461 Modl B, et al., TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis. Cancer Res. 2026 Jan 2;86(1):80-98
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory