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Tyk2 Gene Detail
Summary
  • Symbol
    Tyk2
  • Name
    tyrosine kinase 2
  • Synonyms
    JTK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929470
    NCBI Gene: 54721
  • Gene Overview
    MyGene.info: TYK2
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21104068-21131243 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.71 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    130 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929470
protein coding gene Chr9:21104068-21131275 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034441
protein coding gene Chr9:18286645-18314858 (-)
A/J MGP_AJ_G0034419
protein coding gene Chr9:17985636-18012947 (-)
AKR/J MGP_AKRJ_G0034346
protein coding gene Chr9:18307390-18340741 (-)
BALB/cJ MGP_BALBcJ_G0034410
protein coding gene Chr9:17878533-17907049 (-)
C3H/HeJ MGP_C3HHeJ_G0034122
protein coding gene Chr9:18615889-18645306 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034931
protein coding gene Chr9:19028443-19057746 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031861
protein coding gene Chr9:17113672-17141417 (-)
CAST/EiJ MGP_CASTEiJ_G0033445
protein coding gene Chr9:18444217-18470508 (-)
CBA/J MGP_CBAJ_G0034095
protein coding gene Chr9:19729055-19759536 (-)
DBA/2J MGP_DBA2J_G0034254
protein coding gene Chr9:17963903-17991301 (-)
FVB/NJ MGP_FVBNJ_G0034197
protein coding gene Chr9:17475308-17504385 (-)
LP/J MGP_LPJ_G0034339
protein coding gene Chr9:18460174-18489464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034240
protein coding gene Chr9:21351498-21380930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034951
protein coding gene Chr9:18253289-18286104 (-)
PWK/PhJ MGP_PWKPhJ_G0033151
protein coding gene Chr9:17938146-17965785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032985
protein coding gene Chr9:18321641-18350980 (-)
WSB/EiJ MGP_WSBEiJ_G0033560
protein coding gene Chr9:17993010-18020640 (-)



Homology
more
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TYK2, tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD35, JTK1
  • Links
    NCBI Gene ID: 7297
    neXtProt AC: NX_P29597
    UniProt: P29597

  • Chr Location
    19p13.2; chr19:10350528-10380572 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Tyk2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032175 Ensembl Gene Model | MGI Sequence Detail 27176 C57BL/6J ±  kb
transcript ENSMUST00000001036 Ensembl | MGI Sequence Detail 4619 Not Applicable  
polypeptide ENSMUSP00000001036 Ensembl | MGI Sequence Detail 1207 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    cDNA 15

    Microarray probesets 4
References
more
  • Summaries
    All 83
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 48
  • Earliest
    J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
  • Latest
    J:247177 Raje V, et al., Kinase Inactive Tyrosine Kinase (Tyk2) Supports Differentiation of Brown Fat Cells. Endocrinology. 2017 Jan 01;158(1):148-157

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory