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Tyk2 Gene Detail
Summary
  • Symbol
    Tyk2
  • Name
    tyrosine kinase 2
  • Synonyms
    JTK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929470
    NCBI Gene: 54721
  • Gene Overview
    MyGene.info: TYK2
Location & Maps
more
  • Sequence Map
    Chr9:21104069-21127346 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23278 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.71 cM, cytoband A3
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TYK2, tyrosine kinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMD35, JTK1
  • Links
    NCBI Gene ID: 7297
    neXtProt AC: NX_P29597

  • Chr Location
    19p13.2; chr19:10350528-10380572 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Tyk2 mouse models; 1 with human TYK2 associations

Human Disease Mouse Models
       Obesity   OMIM: 601665 View 1 model
       Immunodeficiency 35; IMD35   OMIM: 611521
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    46 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032175 Ensembl Gene Model | MGI Sequence Detail 23278 C57BL/6J ±  kb
transcript ENSMUST00000001036 Ensembl | MGI Sequence Detail 4619 Not Applicable  
polypeptide ENSMUSP00000001036 Ensembl | MGI Sequence Detail 1207 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    130 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 14

    Microarray probesets 4
References
more
  • Summaries
    All 77
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 5
    Phenotypes 46
  • Earliest
    J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
  • Latest
    J:230644 Mostafavi S, et al., Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28;164(3):564-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory