About   Help   FAQ
Lpar3
Gene Detail
Symbol

Name
ID
Lpar3
lysophosphatidic acid receptor 3
MGI:1929469
Synonyms
Edg7, LPA3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
71.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:146220963-146286186 bp, + strand
From VEGA annotation of GRCm38

  65224 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LPAR3
Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar3

Human
homologs
LPAR3, lysophosphatidic acid receptor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 23566
neXtProt AC: NX_Q9UBY5

Human Synonyms: Edg-7, EDG7, GPCR, HOFNH30, LPA3, LP-A3, RP4-678I3

Human Chr (Location): 1p22.3; chr1:84811602-84893213 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos.
 
Interactions
Lpar3 interacts with 250 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component axon, cytosol, ...
Function G-protein alpha-subunit binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (244)    Tissues (86)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
Northern blot 21
RT-PCR 37
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN lpar3    NEW 
Molecular
reagents
All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000055329 (Evidence)
Ensembl Gene Model ENSMUSG00000036832 (Evidence)
Entrez Gene 65086 (Evidence)
UniGene 155520
DFCI TC1584563
DoTS DT.97380969
NIA Mouse Gene Index U003959
Consensus CDS Project CCDS17901.1
International Mouse Phenotyping Consortium Status Lpar3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055329 VEGA Gene Model | MGI Sequence Detail 65224 C57BL/6J ±  kb
transcript OTTMUST00000136954 VEGA | MGI Sequence Detail 2464 Not Applicable 
polypeptide OTTMUSP00000072188 VEGA | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(385 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004065 Lysophosphatidic acid receptor
InterPro IPR005385 Lysophosphatidic acid receptor EDG-7
Protein Ontology PR:000001686 lysophosphatidic acid receptor 3
References
(Earliest) J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
(Latest) J:217593 Garcia TX, et al., RBPJ in mouse Sertoli cells is required for proper regulation of the testis stem cell niche. Development. 2014 Dec;141(23):4468-78
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory