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Lpar3
Gene Detail
Symbol

Name
ID
Lpar3
lysophosphatidic acid receptor 3
MGI:1929469
Synonyms
Edg7, LPA3
Feature Type
protein coding gene
Genetic Map
Chromosome 3
71.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:146220961-146286214 bp, + strand
From NCBI annotation of GRCm38

  65254 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8123  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: LPAR1/S1PR1-like lysophospholipid receptor
Gene Tree: Lpar3

Human
homologs
Human Homolog LPAR3, lysophosphatidic acid receptor 3
NCBI Gene ID 23566
neXtProt AC  NX_Q9UBY5
Human Synonyms  Edg-7, EDG7, GPCR, HOFNH30, LPA3, LP-A3, RP4-678I3
Human Chr (Location)  1p22.3; chr1:84811602-84893213 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos.
 
Interactions
Lpar3 interacts with 251 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process activation of MAPK activity, bleb assembly, ...
Component axon, cell, ...
Function G-protein alpha-subunit binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (244)    Tissues (86)    Images (57)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 186
Northern blot 21
RT-PCR 37
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(13) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000036832 (Evidence)
Entrez Gene65086 (Evidence)
UniGene155520
DFCITC1584563
DoTSDT.97380969
NIA Mouse Gene IndexU003959
Consensus CDS ProjectCCDS17901.1
International Mouse Knockout Project StatusLpar3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 65086 NCBI Gene Model | MGI Sequence Detail 65254 C57BL/6J ±  kb
transcript NM_022983 RefSeq | MGI Sequence Detail 2494 C57BL/6 
polypeptide Q9EQ31 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(385 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR004065 Lysophosphatidic acid receptor
InterPro IPR005385 Lysophosphatidic acid receptor EDG-7
Protein Ontology PR:000001686 lysophosphatidic acid receptor 3
Graphical View of Protein Domain Structure
References
(Earliest) J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
(Latest) J:210684 David M, et al., Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. J Biol Chem. 2014 Mar 7;289(10):6551-64
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory