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Lpar3 Gene Detail
Summary
  • Symbol
    Lpar3
  • Name
    lysophosphatidic acid receptor 3
  • Synonyms
    Edg7, LPA3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929469
    NCBI Gene: 65086
  • Gene Overview
    MyGene.info: LPAR3
Location & Maps
more
  • Sequence Map
    Chr3:146220963-146286186 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      65224 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 71.03 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LPAR3, lysophosphatidic acid receptor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LPAR3, lysophosphatidic acid receptor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Edg-7, EDG7, GPCR, HOFNH30, LPA3, LP-A3, RP4-678I3
  • Links
    NCBI Gene ID: 23566
    neXtProt AC: NX_Q9UBY5

  • Chr Location
    1p22.3; chr1:84811602-84893213 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Lpar3
  • Incidental Mutations
Homozygous null females produce smaller litter sizes and exhibit delayed implantation and altered embryo spacing that leads to delayed development of embryos and hypertrophic placentas that were shared by multiple embryos.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055329 VEGA Gene Model | MGI Sequence Detail 65224 C57BL/6J ±  kb
transcript OTTMUST00000136954 VEGA | MGI Sequence Detail 2464 Not Applicable  
polypeptide OTTMUSP00000072188 VEGA | MGI Sequence Detail 354 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    387 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001686 lysophosphatidic acid receptor 3
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR004065 Lysophosphatidic acid receptor
    IPR005385 Lysophosphatidic acid receptor EDG-7
Molecular
Reagents
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  • All nucleic 20
    cDNA 13
    Primer pair 5
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 51
    Developmental Gene Expression 15
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:65882 Contos JJ, et al., Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13384-9
  • Latest
    J:227484 Diao H, et al., Deletion of Lysophosphatidic Acid Receptor 3 (Lpar3) Disrupts Fine Local Balance of Progesterone and Estrogen Signaling in Mouse Uterus During Implantation. Biol Reprod. 2015 Nov;93(5):123

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory