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Txn2 Gene Detail
Summary
  • Symbol
    Txn2
  • Name
    thioredoxin 2
  • Synonyms
    2510006J11Rik, Trx2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929468
    NCBI Gene: 56551
Location & Maps
more
  • Sequence Map
    Chr15:77915047-77929006 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13960 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TXN2, thioredoxin 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TXN2, thioredoxin 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MTRX, MT-TRX, TRX2
  • Links
    NCBI Gene ID: 25828
    neXtProt AC: NX_Q99757

  • Chr Location
    22q13.1; chr22:36467036-36482025 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Chemically induced (other)
    2
  • Gene trapped
    23
  • Radiation induced
    2
  • Targeted
    2
  • Genomic Mutations
    4 involving Txn2
  • Incidental Mutations
Mice homozygous for mutations that inactivate the gene exhibit exencephaly and embyronic lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020980 VEGA Gene Model | MGI Sequence Detail 13960 C57BL/6J ±  kb
transcript OTTMUST00000049612 VEGA | MGI Sequence Detail 1298 Not Applicable  
polypeptide OTTMUSP00000023015 VEGA | MGI Sequence Detail 166 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    94 from dbSNP Build 137
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 13
    cDNA 13

    Microarray probesets 5
Other
Accession IDs
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MGI:1915214, MGI:2146059
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 7
    Phenotypes 28
  • Earliest
    J:74095 Kobayashi M, et al., Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Antioxid Redox Signal. 2000 Winter;2(4):653-63
  • Latest
    J:212455 Li C, et al., CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory