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Txn2
Gene Detail
Symbol

Name
ID
Txn2
thioredoxin 2
MGI:1929468
Synonyms
2510006J11Rik, Trx2
Feature Type
protein coding gene
Genetic Map
Chromosome 15
36.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:77915047-77929006 bp, - strand
From VEGA annotation of GRCm38

  13960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40849  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TXN2
Protein SuperFamily: Thioredoxin
Gene Tree: Txn2

Human
homologs
TXN2, thioredoxin 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 25828
neXtProt AC: NX_Q99757

Human Synonyms: MTRX, MT-TRX, TRX2

Human Chr (Location): 22q13.1; chr22:36467036-36482025 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(23) Radiation induced(1) Targeted(2)
Genomic Mutations involving Txn2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations that inactivate the gene exhibit exencephaly and embyronic lethality.
 
Phenotype Images(2)
Interactions
Txn2 interacts with 158 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TXN2 ; Xenbase txn2 ; ZFIN txn2    NEW 
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000020980 (Evidence)
Ensembl Gene Model ENSMUSG00000005354 (Evidence)
Entrez Gene 56551 (Evidence)
DFCI TC1573466, TC1610716
DoTS DT.91388022, DT.101209491, DT.101190921, DT.495797, DT.110828475, DT.94365578
NIA Mouse Gene Index U036372
Consensus CDS Project CCDS27606.1
International Mouse Phenotyping Consortium Status Txn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020980 VEGA Gene Model | MGI Sequence Detail 13960 C57BL/6J ±  kb
transcript OTTMUST00000049612 VEGA | MGI Sequence Detail 1298 Not Applicable 
polypeptide OTTMUSP00000023015 VEGA | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005746 Thioredoxin
InterPro IPR017937 Thioredoxin, conserved site
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016854 thioredoxin, mitochondrial
References
(Earliest) J:74095 Kobayashi M, et al., Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Antioxid Redox Signal. 2000 Winter;2(4):653-63
(Latest) J:212455 Li C, et al., CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. Biochim Biophys Acta. 2014 Jul;1842(7):1121-9
All references(49)
Other
accession IDs
MGI:1915214, MGI:2146059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory