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Txn2
Gene Detail
 Symbol
Name
ID
Txn2
thioredoxin 2
MGI:1929468
Synonyms 2510006J11Rik, Trx2
Feature Type protein coding gene
Genetic Map
Chromosome 15
36.92 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:77915047-77929006 bp, - strand
From VEGA annotation of GRCm38

  13960 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40849  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Thioredoxin
Gene Tree: Txn2

Human
homologs
Human Homolog TXN2, thioredoxin 2
NCBI Gene ID 25828
neXtProt AC  NX_Q99757
Human Synonyms  MTRX, MT-TRX, TRX2
Human Chr (Location)  22q13.1; chr22:36467036-36482025 (-)  GRCh38
Alleles
and
phenotypes
All alleles(25) : Gene trapped(23) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for mutations that inactivate the gene exhibit exencephaly and embyronic lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell redox homeostasis, glycerol ether metabolic process, ...
Component dendrite, mitochondrion, ...
Function peptide-methionine (R)-S-oxide reductase activity, peptide-methionine (S)-S-oxide reductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(13) cDNA(13)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000020980 (Evidence)
Ensembl Gene ModelENSMUSG00000005354 (Evidence)
Entrez Gene56551 (Evidence)
DFCITC1573466, TC1610716
DoTSDT.101190921, DT.101209491, DT.110828475, DT.495797, DT.91388022, DT.94365578
NIA Mouse Gene IndexU036372
Consensus CDS ProjectCCDS27606.1
International Mouse Knockout Project StatusTxn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020980 VEGA Gene Model | MGI Sequence Detail 13960 C57BL/6J ±  kb
transcript OTTMUST00000049612 VEGA | MGI Sequence Detail 1298 Not Applicable 
polypeptide OTTMUSP00000023015 VEGA | MGI Sequence Detail 166 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(2) UniProt(6)
Polymorphisms SNPs within 2kb(94 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005746 Thioredoxin
InterPro IPR017937 Thioredoxin, conserved site
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016854 thioredoxin, mitochondrial
References (Earliest) J:74095 Kobayashi M, et al., Immunohistochemical localization of thioredoxin and glutaredoxin in mouse embryos and fetuses. Antioxid Redox Signal. 2000 Winter;2(4):653-63
(Latest) J:176499 Rederstorff M, et al., Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy. PLoS One. 2011;6(8):e23094
All references(49)
Other
accession IDs
MGI:1915214, MGI:2146059

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory