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Sec11a Gene Detail
Summary
  • Symbol
    Sec11a
  • Name
    SEC11 homolog A, signal peptidase complex subunit
  • Synonyms
    1810012E07Rik, 18kDa, Sec11l1, sid2895, Spc18
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929464
    NCBI Gene: 56529
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80915379-80947550 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.71 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929464
protein coding gene Chr7:80904889-80947780 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032422
protein coding gene Chr7:82914840-82958236 (-)
A/J MGP_AJ_G0032401
protein coding gene Chr7:80967186-81010170 (-)
AKR/J MGP_AKRJ_G0032337
protein coding gene Chr7:82735039-82793791 (-)
BALB/cJ MGP_BALBcJ_G0032413
protein coding gene Chr7:80636831-80680283 (-)
C3H/HeJ MGP_C3HHeJ_G0032126
protein coding gene Chr7:83375339-83424418 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032905
protein coding gene Chr7:86162824-86207839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029913
protein coding gene Chr7:83473470-83514970 (-)
CAST/EiJ MGP_CASTEiJ_G0031454
protein coding gene Chr7:74278970-74324261 (-)
CBA/J MGP_CBAJ_G0032092
protein coding gene Chr7:89032567-89086306 (-)
DBA/2J MGP_DBA2J_G0032247
protein coding gene Chr7:79514236-79563296 (-)
FVB/NJ MGP_FVBNJ_G0032202
protein coding gene Chr7:79448733-79491249 (-)
LP/J MGP_LPJ_G0032328
protein coding gene Chr7:84155519-84200393 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032239
protein coding gene Chr7:89154883-89200126 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032923
protein coding gene Chr7:82171219-82216644 (-)
PWK/PhJ MGP_PWKPhJ_G0031174
protein coding gene Chr7:72718909-72763553 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031015
protein coding gene Chr7:69188397-69237121 (-)
WSB/EiJ MGP_WSBEiJ_G0031572
protein coding gene Chr7:82529659-82579878 (-)



Homology
more
  • Human Ortholog
    SEC11A, SEC11 homolog A, signal peptidase complex subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEC11A, SEC11 homolog A, signal peptidase complex subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    1810012E07Rik, SEC11L1, sid2895, SPC18, SPCS4A
  • Links
    NCBI Gene ID: 23478
    neXtProt AC: NX_P67812
    UniProt: P67812

  • Chr Location
    15q25.2-q25.3; chr15:84669537-84716460 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 56529 NCBI Gene Model | MGI Sequence Detail 32172 C57BL/6J ±  kb
transcript NM_019951 RefSeq | MGI Sequence Detail 1113 Not Specified  
polypeptide Q9R0P6 UniProt | EBI | MGI Sequence Detail 179 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • EC
  • InterPro Domains
    IPR036286 LexA/Signal peptidase-like superfamily
    IPR015927 Peptidase S24/S26A/S26B/S26C
    IPR019758 Peptidase S26A, signal peptidase I, conserved site
    IPR019756 Peptidase S26A, signal peptidase I, serine active site
    IPR001733 Peptidase S26B
    IPR037712 Signal peptidase complex catalytic subunit SEC11A/SEC11B
Molecular
Reagents
less
  • All nucleic 117
    cDNA 117

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916342
References
more
  • Summaries
    All 45
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 19
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:265628 Gaudet P, et al., Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief Bioinform. 2011 Sep;12(5):449-62

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory