Adgrl1 MGI Mouse Gene Detail - MGI:1929461 - adhesion G protein-coupled receptor L1

Symbol

Adgrl1
Name

adhesion G protein-coupled receptor L1
Synonyms

2900070I05Rik, Lec2, lectomedin-2, Lphn1, mKIAA0821

Feature Type

protein coding gene
IDs

MGI:1929461
NCBI Gene: 330814
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr8:84626734-84668583 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 40.22 cM
Mapping Data

3 experiments

SNPs within 2kb

185 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929461	protein coding gene	Chr8:84626598-84668583 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033841	protein coding gene	Chr8:84760111-84801505 (+)
A/J	MGP_AJ_G0033824	protein coding gene	Chr8:81442161-81483449 (+)
AKR/J	MGP_AKRJ_G0033750	protein coding gene	Chr8:83843995-83885287 (+)
BALB/cJ	MGP_BALBcJ_G0033817	protein coding gene	Chr8:81547617-81588872 (+)
C3H/HeJ	MGP_C3HHeJ_G0033527	protein coding gene	Chr8:84459577-84501959 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034337	protein coding gene	Chr8:87984415-88033639 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031279	protein coding gene	Chr8:75239692-75281798 (+)
CAST/EiJ	MGP_CASTEiJ_G0032857	protein coding gene	Chr8:83872663-83914104 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0033658	protein coding gene	Chr8:81078712-81120059 (+)
FVB/NJ	MGP_FVBNJ_G0033604	protein coding gene	Chr8:79999891-80041653 (+)
LP/J	MGP_LPJ_G0033748	protein coding gene	Chr8:84869964-84915487 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033646	protein coding gene	Chr8:93635692-93676993 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034354	protein coding gene	Chr8:83822422-83865595 (+)
PWK/PhJ	MGP_PWKPhJ_G0032561	protein coding gene	Chr8:80295978-80338491 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032398	protein coding gene	Chr8:82628486-82670066 (+)
WSB/EiJ	MGP_WSBEiJ_G0032970	protein coding gene	Chr8:84231978-84273850 (+)

Human Ortholog

ADGRL1, adhesion G protein-coupled receptor L1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ADGRL1, adhesion G protein-coupled receptor L1
Synonyms

CIRL1, CL1, DEDBANP, LEC2, LPHN1
Links

HGNC:20973

NCBI Gene ID: 22859

neXtProt AC: NX_O94910

UniProt: O94910
Chr Location

19p13.12; chr19:14147743-14206187 (-) GRCh38

MGI Vertebrate Homology

Adgrl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ADGRL1
Gene Tree

Adgrl1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

19
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

10
Radiation induced

1
Targeted

6
Genomic Mutations

2 involving Adgrl1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

60 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a targeted null allele at this locus are viable and fertile. Female homozygotes fail adequately to care for their litters.

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All GO Annotations

34
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

791
Tissues

44
cDNA Data

16
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase adgrl1

ZFIN adgrl1a

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All Sequences

141
RefSeq

82
UniProt

7
CCDS

CCDS52613.1

Ensembl

ENSMUSG00000013033 (Evidence)
NCBI Gene

330814

			Length	Strain/Species	Flank
genomic	ENSMUSG00000013033	Ensembl Gene Model \| MGI Sequence Detail	41850	C57BL/6J	± kb
transcript	ENSMUST00000152978	Ensembl \| MGI Sequence Detail	5734	Not Applicable
polypeptide	ENSMUSP00000115295	Ensembl \| MGI Sequence Detail	1516	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000001233 adhesion G protein-coupled receptor L1

(term hierarchy)
PDB

2JX9, 2JXA, 6SKA
InterPro Domains

IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain

IPR043159 D-galactoside/L-rhamnose binding SUEL lectin domain superfamily

IPR032471 GAIN domain, N-terminal

IPR046338 GAIN domain superfamily

IPR001879 GPCR, family 2, extracellular hormone receptor domain

IPR036445 GPCR family 2, extracellular hormone receptor domain superfamily

IPR003924 GPCR, family 2, latrophilin

IPR003334 GPCR, family 2, latrophilin, C-terminal

IPR017981 GPCR, family 2-like, 7TM

IPR000832 GPCR, family 2, secretin-like

IPR017983 GPCR, family 2, secretin-like, conserved site

IPR000203 GPS motif

IPR031234 Latrophilin-1, , transmembrane domain

IPR003112 Olfactomedin-like domain

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All nucleic 16

cDNA 16

Microarray probesets 3

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MGI:1914521, MGI:2142473

Summaries

All 74

Developmental Gene Expression 4

Gene Ontology 7

Phenotypes 38
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:346018 Chhabra KH, et al., ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis. Diabetologia. 2024 Jan;67(1):170-189

TSS for Adgrl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78300	Chr8:84626587-84626598 (+)	-141 bp
Tssr78301	Chr8:84626717-84626722 (+)	-14 bp
Tssr78302	Chr8:84626725-84626739 (+)	-2 bp
Tssr78303	Chr8:84626743-84626794 (+)	35 bp
Tssr78304	Chr8:84627076-84627117 (+)	363 bp
Tssr78305	Chr8:84627221-84627246 (+)	500 bp
Tssr78306	Chr8:84627249-84627274 (+)	528 bp
Tssr78307	Chr8:84627335-84627346 (+)	607 bp
Tssr2622	Chr8:84645532-84645541 (+)	18,803 bp
Tssr78308	Chr8:84656543-84656563 (+)	29,819 bp
Tssr78309	Chr8:84668201-84668224 (+)	41,479 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23