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Adgrl1
Gene Detail
Symbol

Name
ID
Adgrl1
adhesion G protein-coupled receptor L1
MGI:1929461
Synonyms
2900070I05Rik, Lec2, lectomedin-2, Lphn1, mKIAA0821
Feature Type
protein coding gene
Genetic Map
Chromosome 8
40.22 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:83900105-83941954 bp, + strand
From VEGA annotation of GRCm38

  41850 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8951  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ADGRL1
Protein SuperFamily: alpha-latrotoxin receptor, calcium-independent type
Gene Tree: Adgrl1

Human
homologs
ADGRL1, adhesion G protein-coupled receptor L1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 22859
neXtProt AC: NX_O94910

Human Synonyms: CIRL1, CL1, LEC2, LPHN1

Human Chr (Location): 19p13.2; chr19:14147737-14206248 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(10) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null allele at this locus are viable and fertile. Female homozygotes fail adequately to care for their litters.
 
Interactions
Adgrl1 interacts with 440 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (45)    Tissues (31)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adgrl1    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000032839 (Evidence)
Ensembl Gene Model ENSMUSG00000013033 (Evidence)
Entrez Gene 330814 (Evidence)
NIA Mouse Gene Index U009560
PDB 2JX9, 2JXA
Consensus CDS Project CCDS52613.1
International Mouse Phenotyping Consortium Status Adgrl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032839 VEGA Gene Model | MGI Sequence Detail 41850 C57BL/6J ±  kb
transcript OTTMUST00000081806 VEGA | MGI Sequence Detail 5734 Not Applicable 
polypeptide OTTMUSP00000043812 VEGA | MGI Sequence Detail 1516 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(30) UniProt(3)
Polymorphisms
SNPs within 2kb(188 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000922 D-galactoside/L-rhamnose binding SUEL lectin domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR003924 GPCR, family 2, latrophilin
InterPro IPR003334 GPCR, family 2, latrophilin, C-terminal
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR017983 GPCR, family 2, secretin-like, conserved site
InterPro IPR000203 GPS motif
InterPro IPR031234 Latrophilin-1
InterPro IPR003112 Olfactomedin-like domain
Protein Ontology PR:000001233 latrophilin-1
References
(Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:218304 Hamann J, et al., International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein-Coupled Receptors. Pharmacol Rev. 2015 Apr;67(2):338-67
All references(37)
Other
accession IDs
MGI:1914521, MGI:2142473

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory