About   Help   FAQ
Adrm1 Gene Detail
Summary
  • Symbol
    Adrm1
  • Name
    adhesion regulating molecule 1
  • Synonyms
    1110063P18Rik, 2510006J17Rik, ARM-1, Gp110, Rpn13
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929289
    NCBI Gene: 56436
  • Gene Overview
    MyGene.info: ADRM1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:180171490-180176284 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 102.69 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929289
protein coding gene Chr2:180171485-180176286 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026988
protein coding gene Chr2:186676031-186682657 (+)
A/J MGP_AJ_G0026954
protein coding gene Chr2:179006790-179012601 (+)
AKR/J MGP_AKRJ_G0026924
protein coding gene Chr2:184364355-184369450 (+)
BALB/cJ MGP_BALBcJ_G0026963
protein coding gene Chr2:179469604-179474740 (+)
C3H/HeJ MGP_C3HHeJ_G0026704
protein coding gene Chr2:184719958-184724758 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027409
protein coding gene Chr2:192066959-192071760 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024776
protein coding gene Chr2:169698601-169703340 (+)
CAST/EiJ MGP_CASTEiJ_G0026163
protein coding gene Chr2:182961156-182965952 (+)
CBA/J MGP_CBAJ_G0026681
protein coding gene Chr2:199051928-199057402 (+)
DBA/2J MGP_DBA2J_G0026819
protein coding gene Chr2:178109793-178114640 (+)
FVB/NJ MGP_FVBNJ_G0026785
protein coding gene Chr2:176706636-176711600 (+)
LP/J MGP_LPJ_G0026920
protein coding gene Chr2:186668012-186683286 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026804
protein coding gene Chr2:201676347-201683557 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027468
protein coding gene Chr2:184329283-184334083 (+)
PWK/PhJ MGP_PWKPhJ_G0025899
protein coding gene Chr2:175612099-175616898 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025699
protein coding gene Chr2:180816900-180821691 (+)
WSB/EiJ MGP_WSBEiJ_G0026235
protein coding gene Chr2:185294036-185301055 (+)



Homology
more
  • Human Ortholog
    ADRM1, adhesion regulating molecule 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ADRM1, adhesion regulating molecule 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARM1, ARM-1, GP110
  • Links
    NCBI Gene ID: 11047
    neXtProt AC: NX_Q16186
    UniProt: Q16186

  • Chr Location
    20q13.33; chr20:62302056-62308862 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 10513
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: ADRM1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 1 allele in 1 genetic background
    3 images
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit decreased birth weight, reduced competition for food, postnatal lethality, infertility, impaired sperm and oocyte development, increased peripheral CD4+ and CD8+ T cells, and increased serum GH and FSH levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56436 NCBI Gene Model | MGI Sequence Detail 4795 C57BL/6J ±  kb
    transcript NM_019822 RefSeq | MGI Sequence Detail 1429 C57BL/6  
    polypeptide Q9JKV1 UniProt | EBI | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • PDB
    • InterPro Domains
      IPR006773 Proteasomal ubiquitin receptor Rpn13/ADRM1
      IPR038633 Proteasomal ubiquitin receptor Rpn13/ADRM1 superfamily
      IPR032368 UCH-binding domain
      IPR038108 UCH-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 19

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1923583, MGI:1924051, MGI:2139557, MGI:2139913
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 5
    • Earliest
      J:68372 Simins AB, et al., Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells. Clin Exp Metastasis. 1999;17(8):641-8
    • Latest
      J:228828 Hamazaki J, et al., Redundant Roles of Rpn10 and Rpn13 in Recognition of Ubiquitinated Proteins and Cellular Homeostasis. PLoS Genet. 2015 Jul;11(7):e1005401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory