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Cldn12 Gene Detail
Summary
  • Symbol
    Cldn12
  • Name
    claudin 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929288
    NCBI Gene: 64945
  • Gene Overview
    MyGene.info: CLDN12
Location & Maps
more
  • Genetic Map
    Chromosome 5, 2.98 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CLDN12, claudin 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CLDN12, claudin 12
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 9069
    neXtProt AC: NX_P56749

  • Chr Location
    7q21; chr7:90403334-90415954 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotype references
  • All Mutations and Alleles
    8
  • Gene trapped
    5
  • Targeted
    3
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025945 VEGA Gene Model | MGI Sequence Detail 25422 C57BL/6J ±  kb
transcript OTTMUST00000063979 VEGA | MGI Sequence Detail 3597 Not Applicable  
polypeptide OTTMUSP00000031727 VEGA | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    251 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 63
    cDNA 62
    Primer pair 1

    Microarray probesets 4
References
more
  • Summaries
    All 36
    Developmental Gene Expression 8
    Gene Ontology 4
    Phenotypes 6
  • Earliest
    J:72106 Niimi T, et al., claudin-18, a Novel Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor, Encodes Lung- and Stomach-Specific Isoforms through Alternative Splicing. Mol Cell Biol. 2001 Nov;21(21):7380-90
  • Latest
    J:217538 Lui JH, et al., Radial glia require PDGFD-PDGFRbeta signalling in human but not mouse neocortex. Nature. 2014 Nov 13;515(7526):264-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory