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Amotl2 Gene Detail
Summary
  • Symbol
    Amotl2
  • Name
    angiomotin-like 2
  • Synonyms
    Lccp, MASCOT, mKIAA0989
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929286
    NCBI Gene: 56332
  • Gene Overview
    MyGene.info: AMOTL2
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:102717294-102733418 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 54.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    70 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929286
protein coding gene Chr9:102716672-102733418 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035189
protein coding gene Chr9:104294659-104311400 (+)
A/J MGP_AJ_G0035169
protein coding gene Chr9:100553381-100570114 (+)
AKR/J MGP_AKRJ_G0035101
protein coding gene Chr9:103031531-103048533 (+)
BALB/cJ MGP_BALBcJ_G0035162
protein coding gene Chr9:100258557-100276311 (+)
C3H/HeJ MGP_C3HHeJ_G0034872
protein coding gene Chr9:103430675-103448033 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035682
protein coding gene Chr9:107205287-107222031 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032581
protein coding gene Chr9:98140620-98157191 (+)
CAST/EiJ MGP_CASTEiJ_G0034184
protein coding gene Chr9:103246531-103263284 (+)
CBA/J MGP_CBAJ_G0034841
protein coding gene Chr9:110943765-110960511 (+)
DBA/2J MGP_DBA2J_G0035002
protein coding gene Chr9:100044814-100061809 (+)
FVB/NJ MGP_FVBNJ_G0034950
protein coding gene Chr9:98842850-98859585 (+)
LP/J MGP_LPJ_G0035078
protein coding gene Chr9:104501231-104517976 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034989
protein coding gene Chr9:112767600-112784341 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035704
protein coding gene Chr9:103281512-103298262 (+)
PWK/PhJ MGP_PWKPhJ_G0033891
protein coding gene Chr9:100287059-100309947 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033726
protein coding gene Chr9:103322896-103339602 (+)
WSB/EiJ MGP_WSBEiJ_G0034304
protein coding gene Chr9:103157153-103173869 (+)



Homology
more
  • Human Ortholog
    AMOTL2, angiomotin like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AMOTL2, angiomotin like 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    LCCP
  • Links
    NCBI Gene ID: 51421
    neXtProt AC: NX_Q9Y2J4
    UniProt: Q9Y2J4

  • Chr Location
    3q22.2; chr3:134355345-134375417 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 9420
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AMOTL2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Conditional homozygous knockout in endothelial cells during embryonic development leads to aortic restriction in the embryo.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56332 NCBI Gene Model | MGI Sequence Detail 16125 C57BL/6J ±  kb
    transcript NM_019764 RefSeq | MGI Sequence Detail 4191 C57BL/6  
    polypeptide Q8K371 UniProt | EBI | MGI Sequence Detail 772 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143321, MGI:2143406
    References
    more
    • Summaries
      All 46
      Developmental Gene Expression 10
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:256562 Hildebrand S, et al., The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching. Sci Rep. 2017 Aug 25;7(1):9540

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory