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Ptges3
Gene Detail
Symbol

Name
ID
Ptges3
prostaglandin E synthase 3 (cytosolic)
MGI:1929282
Synonyms
5730442A20Rik, cPGES, p23 cochaperone, Ptges, sid3177, Tebp
Feature Type
protein coding gene
Genetic Map
Chromosome 10
76.39 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr10:128058954-128077272 bp, + strand
From VEGA annotation of GRCm38

  18319 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128197  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: Caenorhabditis elegans hypothetical protein ZC395.10
Gene Tree: Ptges3

Human
homologs
Human Homolog PTGES3, prostaglandin E synthase 3 (cytosolic)
NCBI Gene ID 10728
neXtProt AC  NX_Q15185
Human Synonyms  cPGES, P23, TEBP
Human Chr (Location)  12q13.3; chr12:56663341-56688408 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(87) : Gene trapped(85) Targeted(2)
Incidental mutations (data from APF )
 
Disruption of gene function results in neonatal lethality, respiratory system abnormalities, as well as skin morphological and physiological defects.
 
Interactions
Ptges3 interacts with 241 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process cell proliferation, chaperone cofactor-dependent protein refolding, ...
Component actin filament, cytoplasm, ...
Function enzyme binding, Hsp90 protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (11)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 2
Western blot 9
cDNA source data(143)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(144) cDNA(144)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020944 (Evidence)
Ensembl Gene ModelENSMUSG00000071072 (Evidence)
Entrez Gene56351 (Evidence)
UniGene305816
DFCITC1572259
DoTSDT.110631198, DT.101379763, DT.495145, DT.97336806
NIA Mouse Gene IndexU012170, U050253
EC5.3.99.3
Consensus CDS ProjectCCDS36087.1
International Mouse Knockout Project StatusPtges3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020944 VEGA Gene Model | MGI Sequence Detail 18319 C57BL/6J ±  kb
transcript OTTMUST00000049509 VEGA | MGI Sequence Detail 2000 Not Applicable 
polypeptide OTTMUSP00000022954 VEGA | MGI Sequence Detail 160 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007052 CS-like domain
InterPro IPR008978 HSP20-like chaperone
Protein Ontology PR:000013423 prostaglandin E synthase 3
References
(Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(45)
Other
accession IDs
MGI:1913886

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory